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CAS No. 405060-95-9
Chemical Name: SALUBRINAL
Synonyms: SAL;SALUBRINAL;N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide;(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide;3-PHENYL-N-[2,2,2-TRICHLORO-1-[[(8-QUINOLINYLAMINO)THIOXOMETHYL]AMINO]ETHYL]-2-PROPENAMIDE;(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide;2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-;Salubrinal (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide;(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Salubrinal
CBNumber: CB3322523
Molecular Formula: C21H17Cl3N4OS
Formula Weight: 479.81
MOL File: 405060-95-9.mol
storage temp. : Store at +4°C
Water Solubility : Insoluble in water.
Sensitive : Light Sensitive
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes : Xi
Risk Statements : 36/37/38
Safety Statements : 26
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

SALUBRINAL Chemical Properties,Usage,Production

Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. Salubrinal can protect PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM) and prevent replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α. As eIF2α has a role in bone formation, salubrinal is also being studied for its effects in osteoporosis. Besides, it also shows potential neuroprotective actions. Although salubrinal has putative therapeutic value due to its function, it is as yet only used experimentally.
Salubrinal is an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons
Biological Activity
Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).
SALUBRINAL Preparation Products And Raw materials
Raw materials
Preparation Products
SALUBRINAL Suppliers      Global( 47)Suppliers     
Supplier Tel Fax Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933; China 96832 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 China 15950 69
VDM Biochemicals 0330-2528181
0330-2528171 United States 511 64
Chemsky(shanghai)International Co.,Ltd. 021-50135380 China 32539 50
ShangHai Biochempartner Co.,Ltd +86 13818785766,400-021-9906 China 1167 62
BOC Sciences 1-631-504-6093
1-631-614-7828 United States 10005 65
Dalian Meilun Biotech Co., Ltd. 0411-66771943;0411-66771942
0411-66771945 China 4846 58
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 China 11135 61
UHN Shanghai Research & Development Co., Ltd. +86 (21) 5895-8002
+86 (21) 5895-8628 China 1034 58
Shanghai Aladdin Bio-Chem Technology Co.,LTD 021-20337333/400-620-6333
021-50323701 China 28587 65
405060-95-9(SALUBRINAL)Related Search:
MLN9708 CYCLOPAMINE GSK2656157 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine ABT 263 Rapamycin SALUBRINAL
SALUBRINAL SAL 3-PHENYL-N-[2,2,2-TRICHLORO-1-[[(8-QUINOLINYLAMINO)THIOXOMETHYL]AMINO]ETHYL]-2-PROPENAMIDE 405060-95-9 C21H17Cl3N4OS Apoptosis Inhibitors C21H17N4OSCl3 (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide 2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)- (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Salubrinal Salubrinal (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide Inhibitors N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide
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