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Ethambutol structure
Chemical Name:
emb;C06984;tibutol;MGC71745;diambutol;Etambutol;ETHAMBUTOL;d-ethambutol;EthaMbutol API;Ethambutol BP98
Molecular Formula:
Formula Weight:
MOL File:

Ethambutol Properties

Melting point:
Boiling point:
D25 +13.7° (c = 2 in water)
1.0048 (rough estimate)
refractive index 
1.4610 (estimate)
Flash point:
storage temp. 
pKa 6.6 (H2O) (Uncertain);9.5(H3O) (Uncertain)
Water Solubility 
Soluble in water. Also soluble in chloroform and methylene chloride
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazardous Substances Data 74-55-5(Hazardous Substances Data)
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P330 Rinse mouth.

Ethambutol price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

Ethambutol Chemical Properties,Uses,Production




ChEBI: An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial d ug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant str ins of M. tuberculosis are readily produced if ethambutol is used alone.

brand name

Myambutol (Stat Trade);Aethambutolum;Embutol;Etbutol.

Antimicrobial activity

Ethambutol is active against several species of mycobacteria and nocardiae. MICs on solid media are: M. tuberculosis 0.5–2 mg/L; M. kansasii 1–4 mg/L; other slowly growing mycobacteria 2–8 mg/L; rapidly growing pathogens 2–16 mg/L; Nocardia spp. 8–32 mg/L.
Resistance is uncommon and is a multistep process due to mutations in the embA, embB and embC gene cluster. A mutation in codon 306 of the embB gene predisposes to the development of resistance to a range of antituberculosis agents, possibly by affecting cell-wall permeability.

Pharmaceutical Applications

A synthetic ethylenediamine derivative formulated as the dihydrochloride for oral administration. The dry powder is very soluble and stable.


Oral absorption: c. 80%, but some patients absorb it poorly
Cmax 25 mg/kg oral: 2–6 mg/L after 2–3 h
Plasma half-life: 10–15 h
Volume of distribution: >3 L/kg
Plasma protein binding: 20–30%
Absorption is impeded by aluminum hydroxide and alcohol. It is concentrated in the phagolysosomes of alveolar macrophages. It does not enter the cerebrospinal fluid (CSF) in health but CSF levels of 25–40% of the plasma concentration, with considerable variation between patients, are achieved in cases of tuberculous meningitis.
Various metabolites are produced, including dialdehyde, dicarboxylic acid and glucuronide derivatives. Around 50% is excreted unchanged in the urine, with an additional 10–15% as metabolites, and 20% is excreted unchanged in feces.

Clinical Use

Tuberculosis (initial intensive phase of short-course therapy)
Other mycobacterioses (M. kansasii, M. xenopi, M. malmoense and the M. avium complex) (with appropriate additional drugs)

Side effects

The most important side effect is optic neuritis, which may be irreversible if treatment is not discontinued. This complication is rare if the higher dose (25 mg/kg) is given for no more than 2 months. National codes of practice for prevention of ocular toxicity should be adhered to; in particular, patients should be advised to stop therapy and seek medical advice if they notice any change in visual acuity, peripheral vision or color perception, and the drug should not be given to young children and others unable to comply with this advice.
Other side effects include gastrointestinal upsets, peripheral neuritis, arthralgia, nephritis, myocarditis, hyperuricemia, dermal hypersensitivity and, rarely, thrombocytopenia and hepatotoxicity.

Ethambutol Preparation Products And Raw materials

Raw materials

Preparation Products

Ethambutol Suppliers

Global( 45)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 CHINA 541 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
LGM Pharma 1-(800)-881-8210
615-250-9817 United States 1943 70
Syntechem Co.,Ltd Please Email
E-Mail Inquiry China 13013 57
Spectrum Chemical Manufacturing Corp. 021-67601398,18616765336,QQ:3003443155
021-57711696 China 9692 60
Hangzhou J&H Chemical Co., Ltd. +86-0571-87396432
+86-0571-87396431 China 13902 53
Hubei Jusheng Technology Co.,Ltd North:027-59599241,18871490274,QQ:1400878000 South:027-59599240,18871490354,QQ:1400868000
FAX:027-59599240 China 9875 58
LETOPHARM LIMITED +86-21-5821 5861
+86-21-5106 2861 China 2392 58
Chizhou Kailong Import and Export Trade Co., Ltd. Please Email
- China 9567 50
Watson International Ltd. 86-0512-81863996; +44 (0)20 360 89 360-31
86-512-81867260/70/80-3; +44 (0)20 360 89 360-31-9 China 14920 58

View Lastest Price from Ethambutol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-04-11 Ethambutol
US $10.00 / KG 1G 99% 10MT Hubei XinRunde Chemical Co., Ltd.

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