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N-Boc-N'-Cbz-L-lysine

N-Boc-N'-Cbz-L-lysine structure

CAS No.: 2389-45-9

Chemical Name:: N-Boc-N'-Cbz-L-lysine

Synonyms: BOC-LYS(Z);BOC-Z-LYSINE;BOC-LYS(Z)-OH;-Boc-NεBOC-L-LYS(Z)-OH;BOC-LYS(CBZ)-OH;BOC-LYSINE(Z)-OH;Boc-L-Lys(Cbz)-OH;BOC-L-LYSINE(CBZ);BOC-N-E-Z-L-LYSINE

CBNumber:: CB3325711

Molecular Formula:: C19H28N2O6

Molecular Weight:: 380.44

MDL Number:: MFCD00065584

MOL File:: 2389-45-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:42

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N-Boc-N'-Cbz-L-lysine Properties

Melting point	75.0 to 79.0 °C
Boiling point	587.0±50.0 °C(Predicted)
Density	1.176±0.06 g/cm3(Predicted)
refractive index	-8 ° (C=2.5, AcOH)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	almost transparency in Acetic acid
form	powder to crystal
pka	3.99±0.21(Predicted)
color	White to Almost white
BRN	1917222
InChIKey	BDHUTRNYBGWPBL-HNNXBMFYSA-N
SMILES	C(O)(=O)[C@H](CCCCNC(OCC1=CC=CC=C1)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference	2389-45-9(CAS DataBase Reference)
EPA Substance Registry System	N2-tert-Butoxycarbonyl-N6-benzyloxycarbonyl lysine (2389-45-9)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Safety Statements

24/25

WGK Germany

TSCA

Yes

HS Code

2924 29 70

NFPA 704

	1
0		0

N-Boc-N'-Cbz-L-lysine price More Price(53)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53012	Boc-Lys(Z)-OH (cryst) Novabiochem?	2389-45-9	25g	$155	2024-03-01	Buy
Sigma-Aldrich	B8254	Boc-Lys(Z)-OH	2389-45-9	10g	$257	2023-06-20	Buy
Sigma-Aldrich	8.53012	Boc-Lys(Z)-OH (cryst) Novabiochem?	2389-45-9	100g	$450	2023-01-07	Buy
TCI Chemical	B1632	Nalpha-(tert-Butoxycarbonyl)-Nepsilon-carbobenzoxy-L-lysine >98.0%(HPLC)(T)	2389-45-9	5g	$18	2024-03-01	Buy
TCI Chemical	B1632	Nalpha-(tert-Butoxycarbonyl)-Nepsilon-carbobenzoxy-L-lysine >98.0%(HPLC)(T)	2389-45-9	25g	$60	2024-03-01	Buy

Product number	Packaging	Price	Buy
8.53012	25g	$155	Buy
B8254	10g	$257	Buy
8.53012	100g	$450	Buy
B1632	5g	$18	Buy
B1632	25g	$60	Buy

N-Boc-N'-Cbz-L-lysine Chemical Properties,Uses,Production

Uses

Boc-Lys(Z)-OH, is used in the synthesis of Isodesmosine Chloride (I815050), which is a component of elastin.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

13139-17-8

13734-28-6

2389-45-9

The general procedure for the synthesis of N-Boc-N'-Cbz-L-lysine from N-alpha-Boc-L-lysine and phenylmethoxycarbonylsuccinimide was as follows: to a mixed solution of (2S)-6-amino-2-(tert-butoxycarbonylamino)hexanoic acid (100.00 g, 406.01 mmol, 1.00 equiv) and NaHCO3 (102.33 g 1.22 mol, 3.00 eq.) in a mixed solution of THF (1000 mL) and water (1000 mL) was slowly added CbzOSu (101.19 g, 406.01 mmol, 1.00 eq.) at 0 °C. Subsequently, the reaction mixture was stirred at 30 °C for 16 hours. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 5-6 with 1N HCl and then extracted with ethyl acetate (600 mL x 3). The organic phases were combined, dried with anhydrous Na2SO4 and concentrated under reduced pressure to afford the target product (2S)-6-(benzyloxycarbonylamino)-2-(tert-butoxycarbonylamino)hexanoic acid (142.00 g, 373.26 mmol, 91.9% yield) as a yellow oil.

References

[1] Patent: US2016/96830, 2016, A1. Location in patent: Paragraph 0368-0369

N-Boc-N'-Cbz-L-lysine synthesis

Synthesis of N-Boc-N'-Cbz-L-lysine from N-(Benzyloxycarbonyloxy)succinimide and Boc-Lys-OH

N-Boc-N'-Cbz-L-lysine Preparation Products And Raw materials

Raw materials

N-(Benzyloxycarbonyloxy)succinimide Boc-Lys-OH Water Sodium bicarbonate Tetrahydrofuran

Preparation Products

(S)-(2-OXO-AZEPAN-3-YL)-CARBAMIC ACID TERT-BUTYL ESTER N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol BOC-LYS(NICOTINOYL)-OH N-α-Boc-N-ε-isopropyl-L-lysine

N-Boc-N'-Cbz-L-lysine Suppliers

Global( 374)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Baishixing Science and Technology Industry Co.,Ltd	+86-15008457246	yuki@cd-bsx.com	China	53	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+8615350851019	admin@86-ss.com	China	1000	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	6614	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29731	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Chengdu Baishixing Science and Technology Industry Co.,Ltd	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58

View Lastest Price from N-Boc-N'-Cbz-L-lysine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-07-28	N-Boc-N'-Cbz-L-lysine 2389-45-9	US $999.00-800.00 / kg	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2025-06-25	N-Boc-N'-Cbz-L-lysine 2389-45-9	US $2.00-5.00 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2024-06-13	N-Boc-N'-Cbz-L-lysine 2389-45-9	US $0.00 / kg	1kg	97%	2T/month	Chengdu Baishixing Science and Technology Industry Co.,Ltd

N-Boc-N'-Cbz-L-lysine
2389-45-9
US $999.00-800.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

N-Boc-N'-Cbz-L-lysine
2389-45-9
US $2.00-5.00 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

N-Boc-N'-Cbz-L-lysine
2389-45-9
US $0.00 / kg
97%
Chengdu Baishixing Science and Technology Industry Co.,Ltd

N-Boc-N'-Cbz-L-lysine Spectrum

N-Boc-N'-Cbz-L-lysine(2389-45-9)MS N-Boc-N'-Cbz-L-lysine(2389-45-9)¹HNMR N-Boc-N'-Cbz-L-lysine(2389-45-9)¹³CNMR N-Boc-N'-Cbz-L-lysine(2389-45-9)IR1 N-Boc-N'-Cbz-L-lysine(2389-45-9)IR2

2389-45-9(N-Boc-N'-Cbz-L-lysine)Related Search:

Iminodibenzyl Poly-L-lysine 6-Aminocaproic acid N-Carbobenzyloxyglycine tert-Butyl carbazate

L-Lysine Hexanoic acid Poly(L-lysine hydrobromide) N-Boc-N'-Fmoc-D-lysine N-Boc-N'-Fmoc-L-Lysine

Boc-His(Trt)-OH N-alpha-t-Butyloxycarbonyl-N-epsilon-benzyloxycarbonyl-L-lysinol Boc-D-Ser(Bzl)-OH N-BOC-O-Benzyl-L-serine BOC-4-OXO-L-PROLINE TERT-BUTYL ESTER

N-BOC-L-Prolinal N-Boc-D-alaninol N-Boc-D-Phenylalaninol

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N6-Benzyloxycarbonyl-N2-tert-butoxycarbonyl-L-lysine 2-(tert-Butoxycarbonylamino)-6-(benzoxycarbonylamino)hexanoic acid BOC-Z-LYSINE BOC-N-E-Z-L-LYSINE N-tert-Butoxycarbonyl-Nε-Cbz-L-lysine NALPHA-BOC-NEPSILON-CBZ-L-LYSINE NALPHA-BOC-NEPSILON-Z-L-LYSINE N-ALPHA-T-BUTYLOXYCARBONYL-N-EPSILON-BENZYLOXYCARBONYL-L-LYSINE NALPHA-(TERT-BUTOXYCARBONYL)-NEPSILON-CARBOBENZOXY-L-LYSINE NALPHA-TERT-BUTOXYCARBONYL-NOMEGA-BENZYLOXYCARBONYL-L-LYSINE N ALPHA-T-BUTOXYCARBONYL-N OMEGA-BENZYLOXYCARBONYL-L-LYSINE N-ALPHA-T-BUTOXYCARBONYL-N-EPSILON-CARBOBENZOXY-L-LYSINE N-ALPHA-TERT-BUTYLOXYCARBONYL-N-EPSILON-BENZYLOXYCARBONYL-L-LYSINE N-ALPHA-T-BOC-N-EPSILON-BENZYLOXYCARBONYL-L-LYSINE N-ALPHA-T-BOC-N-EPSILON-CBZ-L-LYSINE NEPSILON-Z-NALPHA-BOC-L-LYSINE N-(tert-butoxycarbonyl)-N-Z-L-lysine Nα-Boc-Nε-Z-L-lysine, Nε-Z-Nα-Boc-L-lysine, Nα-Boc-Nε-Cbz-L-lysine N2-(tert-Butoxycarbonyl)-N6-(benzyloxycarbonyl)-L-lysine N2-(tert-Butoxycarbonyl)-N6-(benzyloxycarbonyl)lysine N2-(tert-Butyloxycarbonyl)-N6-(benzyloxycarbonyl)lysine N6-(Benzyloxycarbonyl)-N2-(tert-butyloxycarbonyl)-L-lysine Nα-Boc-Nε-Z-L-Lys-OH Boc-Lysine(Cbz)-OH Nα-BOC-Nε-L-lysine N-Boc-N'-Cbz-L-lysin Nalpha-Boc-Nepsilon-Cbz-L-lysine Boc-Lys(Z)-OH N^e-Benzyloxycarbonyl-N^a-Boc-L-lysine, 95% Nα- (tert-Butoxycarbonyl)-Nε-carbobenzoxy-L-lysine ,99% (S)-6-(((benzyloxy)carbonyl)aMino)-2-((tert-butoxycarbonyl)aMino)hexanoic acid -Boc-N&epsilon Boc-L-Lys(Cbz)-OH nα-boc-nε-cbz-l-lysine NALPHA-BOC-NEPSILON-CBZ-L-LYSINE,FREEACID Nalpha-t-Butoxycarbonyl-Nw-benzyloxycarbonyl-L-lysine (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-6-(phenylmethoxycarbonylamino)hexanoic acid Boc-L-Lys(Z)-OH (cryst.) Nα-Boc-Nε-Z-L-lysine99% Nepsilon-Benzyloxycarbonyl-Nalpha-Boc-L-lysine N_α-Boc-N_ε-Cbz-L-lysine N_α-Boc-N_ε-Z-L-lysine Boc-Lys(Z)-OH (cryst.) Butoxycarbonylepsilumcarbobenzoxylysine,98% N^(alpha)-(tert-Butoxycarbonyl)-N^(epsilum)-carbobenzoxy-L-lysine NA-T-BOC-N-Epsilon-CBZ-L-Lysine n2-[(1,1-dimethylethoxy)carbonyl]-n6-[(phenylmethoxy)carbonyl]-l-lysin na-t-boc-n-epsilon-cbz-l-lysine*freeacid N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine Amino acid derives N-α-Boc-N-δ-Z-L-lysine BOC-L-LYS(Z)-OH BOC-L-LYSINE(CBZ) BOC-N-EPSILON-Z-L-LYSINE BOC-LYS(CBZ)-OH BOC-LYSINE(Z)-OH BOC-LYS(Z) BOC-LYS(Z)-OH N-ALPHA-BOC-N-EPSILON-BENZYLOXYCARBONYL-L-LYSINE