2,4-Dichloro-5-thiazolecarboxaldehyde
- CAS No.
- 92972-48-0
- Chemical Name:
- 2,4-Dichloro-5-thiazolecarboxaldehyde
- Synonyms
- e-5-carbaL;oro-1,3-thiazoL;BUTTPARK 121\04-87;IFLAB-BB F2124-0686;2,4-DICHLORO-5-FORMYLTHIAZOLE;2,4-Dichloro-5-formyl-1,3-thiazole;2,4-DICHLOROTHIAZOLE-5-CARBALDEHYDE;2,4-Dichloro-thiazol-5-carbaldehyde;2,4-DICHLOROTHIAZOL-5-CARBOXALDEHYDE;2,4-DICHLORO-5-THIAZOLECARBOXALDEHYDE
- CBNumber:
- CB3328000
- Molecular Formula:
- C4HCl2NOS
- Molecular Weight:
- 182.03
- MDL Number:
- MFCD00793013
- MOL File:
- 92972-48-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2,4-Dichlorothiazole-5-carboxaldehyde 97% | 724300 | 1g | $75.7 |
| 2,4-DICHLORO-5-FORMYLTHIAZOLE 95% | 22518 | 1G | $33 |
| 2,4-DICHLORO-5-FORMYLTHIAZOLE 95% | 22518 | 5G | $77 |
| 2,4-Dichloro-5-thiazolecarboxaldehyde | D435925 | 250mg | $50 |
| 2,4-Dichloro-5-thiazolecarboxaldehyde | D435925 | 1g | $90 |
| More product size | |||
| Melting point | 47-53℃ |
|---|---|
| Boiling point | 307.1±45.0 °C(Predicted) |
| Density | 1.690±0.06 g/cm3(Predicted) |
| Flash point | >110°C |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -3.71±0.10(Predicted) |
| color | Pale Beige |
| InChI | 1S/C4HCl2NOS/c5-3-2(1-8)9-4(6)7-3/h1H |
| InChIKey | CFEKBKCGPASOFI-UHFFFAOYSA-N |
| SMILES | Clc1nc(Cl)c(C=O)s1 |
| CAS DataBase Reference | 92972-48-0(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H319 | |||||||||
| Precautionary statements | P301+P310+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-36-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 29341000 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 |
|||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2,4-Dichloro-5-thiazolecarboxaldehyde price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 724300 | 2,4-Dichlorothiazole-5-carboxaldehyde 97% | 92972-48-0 | 1g | $75.7 | 2023-06-20 | Buy |
| AstaTech | 22518 | 2,4-DICHLORO-5-FORMYLTHIAZOLE 95% | 92972-48-0 | 1G | $33 | 2026-04-30 | Buy |
| AstaTech | 22518 | 2,4-DICHLORO-5-FORMYLTHIAZOLE 95% | 92972-48-0 | 5G | $77 | 2026-04-30 | Buy |
| TRC | D435925 | 2,4-Dichloro-5-thiazolecarboxaldehyde | 92972-48-0 | 250mg | $50 | 2021-12-16 | Buy |
| TRC | D435925 | 2,4-Dichloro-5-thiazolecarboxaldehyde | 92972-48-0 | 1g | $90 | 2021-12-16 | Buy |
2,4-Dichloro-5-thiazolecarboxaldehyde Chemical Properties,Uses,Production
Uses
2,4-Dichloro-5-thiazolecarboxaldehyde is used in the synthesis of some novel thiazolidine-2,4-dione derivatives having antimicrobial activity.
Synthesis
2295-31-0
68-12-2
92972-48-0
General procedure for the synthesis of 2,4-dichlorothiazole-5-carboxaldehyde (330): 2,4-thiazolidinedione (329, 2.7 g, 23.07 mmol) was dissolved in N,N-dimethylformamide (DMF, 1.23 mL, 15.98 mmol) at 0 °C and protected by argon and slowly added dropwise to phosphorus trichloride (8.15 mL, 87.17 mmol) (8.15 mL, 87.17 mmol), and the dropwise addition time was controlled at 15 min. Subsequently, the reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Next, the reaction system was heated to 120 °C and stirring was continued for 4 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was carefully poured into pre-cooled ice water and extracted with dichloromethane (CH2Cl2, 3 x 100 mL). The organic phases were combined, washed sequentially with saturated sodium bicarbonate solution (100 mL) and water (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with 5% ethyl acetate/hexane as eluent, and the target compound 330 (1.4 g, 33% yield) was finally obtained as a brown oil.TLC conditions: 30% ethyl acetate/hexane (Rf=0.8).1H NMR (500 MHz, DMSO-d6): δ9.87 (s, 1H).
References
[1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992, # 8, p. 973 - 978
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 1, p. 235 - 238
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 10, p. 2435 - 2444
[4] Patent: US2010/298334, 2010, A1. Location in patent: Page/Page column 78
[5] Chemistry of Heterocyclic Compounds, 2010, vol. 46, # 3, p. 334 - 341
2,4-Dichloro-5-thiazolecarboxaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52705 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
View Lastest Price from 2,4-Dichloro-5-thiazolecarboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 2,4-Dichloro-5-thiazolecarboxaldehyde
92972-48-0
|
US $1.00 / KG | 1KG | 95% | 500KG | Career Henan Chemical Co |
-
- 2,4-Dichloro-5-thiazolecarboxaldehyde
92972-48-0
- US $1.00 / KG
- 95%
- Career Henan Chemical Co
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