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Oxiracetam

CAS No.
62613-82-5
Chemical Name:
Oxiracetam
Synonyms
ct-848;isf2522;Neurome;Neuractiv;CGP 21690;oxiraceta;xiracetam;OXIRACETAM;Oxriacetam;CGP 21690E
CBNumber:
CB3328242
Molecular Formula:
C6H10N2O3
Formula Weight:
158.16
MOL File:
62613-82-5.mol

Oxiracetam Properties

Melting point
165-168 °C
Boiling point
494.6±40.0 °C(Predicted)
Density
1.416
storage temp.
Sealed in dry,Room Temperature
pka
13.76±0.20(Predicted)
Merck
14,6942
InChIKey
IHLAQQPQKRMGSS-UHFFFAOYSA-N
CAS DataBase Reference
62613-82-5(CAS DataBase Reference)
FDA UNII
P7U817352G
ATC code
N06BX07

SAFETY

Risk and Safety Statements

Hazard Codes  Xi
Risk Statements  36/38
Safety Statements  26-36
WGK Germany  3
RTECS  UX9656638

Oxiracetam price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical O0398 Oxiracetam >96.0%(GC)(N) 62613-82-5 1g $96 2022-04-27 Buy
TCI Chemical O0398 Oxiracetam >96.0%(GC)(N) 62613-82-5 5g $323 2022-04-27 Buy
TRC O846905 Oxiracetam 62613-82-5 1g $120 2021-12-16 Buy
ApexBio Technology B4748 Oxiracetam 62613-82-5 100mg $280 2021-12-16 Buy
ChemScene CS-8012 Oxiracetam 99.76% 62613-82-5 100mg $280 2021-12-16 Buy
Product number Packaging Price Buy
O0398 1g $96 Buy
O0398 5g $323 Buy
O846905 1g $120 Buy
B4748 100mg $280 Buy
CS-8012 100mg $280 Buy

Oxiracetam Chemical Properties,Uses,Production

Indications and Usage

Oxiracetam is a more potent derivative of the nootropic drug piracetam. They were developed in 1974 by the Italian company ICF and went on sale in 1987. Oxiracetam is a Piracetam derivative and excites the central nervous system, promotes brain metabolism, significantly increases and promotes memory retention, and effectively treats senile memory and mental decline. It is used to treat brain dysfunction psychiatric syndrome and mental disorders. It can improve the memory and learning abilities of patients with senile dementia or memory disorders. It is suitable for treating neural dysfunction, memory disorder and intelligence disorders caused by brain damage. It can also be used as a recovery treatment for neurosis, brain trauma, encephalitis, and other brain diseases. Oxiracetam’s greatest advantage is that it is very soluble in water, making it suitable for injection. Research shows that Oxiracetam has higher pharmacological activity and significant curative effects compared to Piracetam.

Mechanisms of Action

Oxiracetam’s mechanisms of action are similar to those of Piracetam. It promotes the binding of phosphorylcholine and phosphoethanolamine, increases the ratio of ATP/ADP in the brain, and increases the binding of protein with nucleic acids in the brain, thus improving the memory and learning ability of patients with senile dementia and memory disorder.

Pharmacokinetics

After intake, most of the drug will not accumulate in the body and will be excreted through urine in its original form. It is well-absorbed and well-tolerated.

Clinical Research

Animal trials showed that in all types of behavioral experiments, Oxiracetam can improve memory retention and learning ability, reduce brain shocks’ damage on memory, and prevent the learning abilities of rats suffering from spontaneous hypertensive cerebrovascular injury from decreasing. It can also increase acetylcholine circulation in rats’ skin and hippocampus, thus increasing affinity for choline uptake.

Description

Oxiracetam is a structural analogue of piracetam. This compound has enhancing effects on vigilance and memory. In comparison with piracetam, oxiracetam exhibits greater improvement in memory (Itil et al., 1986) and has been used extensively for the treatment of dementia, including AD, VaD, MID (Baumel et al., 1989; Dysken et al., 1989), and mixed forms. Green et al. (1992) failed to demonstrate a difference from placebo in AD patients. In contrast, Maina et al. (1989) studied 289 patients with MID in a double-blind placebo-controlled trial and after 12 weeks of treatment found that oxiracetam reduced behavioural symptoms.

Chemical Properties

Whie Solid

Originator

ISF (Italy)

Uses

Oxiracetam is a 4-hydroxy analog of piracetam with psychostimulant activity, reportedly useful in relieving the symptoms of cerebral insufficiency in the elderly.

brand name

Neuromet

Biochem/physiol Actions

Nootropic agent, improves learning and memory, and prevents impairment of cognitive functions. Its mechanism of action in not yet known, but it is suggested to modulate glutamatergic and cholinergic neurotransmission. Protein kinase C may be involved.

Purification Methods

This nootropic (Alzheimer) drug is purified by recrystallisation from MeOH or aqueous Me2CO and dried in vacuo. [NMR, IR: Pifferi & Pinza Farmaco Ed Sci 32 602 1977, Banfi et al. Farmaco Ed Sci 39 16 1984, Gouilaev & Senning Brain Research Rev 19 180 1994.]

Oxiracetam Preparation Products And Raw materials

Global( 418)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872 christine@shengqipharm.com CHINA 494 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 19994 60
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 info@tianfuchem.com China 22022 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9519 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com sales03@shyrchem.com CHINA 739 60
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+8615102730682 bruce@xrdchem.cn CHINA 567 55
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career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29960 58
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17791478691 yklbiotech@163.com CHINA 297 58
HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
+86-86-18903210395 +86-19930599843 cindy@hbyingong.com China 741 58

Related articles

  • Pharmacokinetics of Oxiracetam
  • Oxiracetam is a structural analogue of piracetam. This compound has enhancing effects on vigilance and memory.
  • May 5,2022

View Lastest Price from Oxiracetam manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-05-06 Oxiracetam
62613-82-5
US $200.00 / kg 10kg 99% 500kg/month HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
2022-04-24 Oxiracetam
62613-82-5
US $300.00 / g 100g 99.9% 10000 Zhuzhou Yaozhijie Chemical Co., LTD
2022-02-25 Oxiracetam
62613-82-5
US $9.90-9.90 / g 1kit 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customized packaging 10000kits/Month Wuhan Biocar Pharmacy Co., Ltd.
  • Oxiracetam
    62613-82-5
  • US $200.00 / kg
  • 99%
  • HEBEI YINGONG NEW MATERIAL TECHNOLOGY CO.,LTD
  • Oxiracetam
    62613-82-5
  • US $300.00 / g
  • 99.9%
  • Zhuzhou Yaozhijie Chemical Co., LTD
  • Oxiracetam
    62613-82-5
  • US $9.90-9.90 / g
  • 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customized packaging
  • Wuhan Biocar Pharmacy Co., Ltd.
4-HYDROXY-2-OXOPYRROLIDINE-N-ACETAMIDE 4-hydroxy-2-oxo-1-pyrrolidineacetamid 4-hydroxy-2-oxo-1-pyrrolidineacetamide 4-hydroxypiracetam ct-848 hydroxypiracetam Oxiracetam, >=99% 2-(4-HYDROXY-PYRROLIDINO-2-ON-1-YL)ETHYL ACETATE 4-1-lydroxypiracetan Oxiracetam 99.7% isf2522 OXIRACETAM Oxriacetam 2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetamide Neuractiv Neurome OXIRACETAM; ISF2522; CGP 21690 CGP 21690E (S)-2-(4-Hydroxy-2-oxopyrrolidin-1-yl)acetaMide oxiraceta -HYDROXY-2-OXOPYRROLIDINE-N-ACETAMIDE Oxiracetam(Random Configuration) (88929-35-5) oxiracetam Oxiracetam Oxiracetam Oxiracetam> 2-(4-Hydroxy-2-oxo-1-pyrrolidinyl)acetamide Oxiracetam USP/EP/BP xiracetam 4-hydroxy-2-oxo-1- TIANFU-CHEM CAS:62613-82-5 4-Hydroxy-2-oxopyrrolidine-N-acetamide 62613-82-5 62613-82-8 pharmaceutical intermediate Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Brain health drug Nootropic Pharmaceutical material and intermeidates APIs API (intermediate of oxiracetam)