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Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride

Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride structure

CAS No.: 1278405-51-8

Chemical Name:: Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride

Synonyms: CHK-IN-1;CHKIN1,CHK IN 1;Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride

CBNumber:: CB33339722

Molecular Formula:: C18H19ClFN5OS

Molecular Weight:: 407.8927632

MDL Number:: MFCD31382099

MOL File:: 1278405-51-8.mol

Last updated:2023-06-01 08:28:59

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Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride Properties

storage temp.	Store at -20°C
solubility	Soluble in DMSO

Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride Chemical Properties,Uses,Production

Description

CHK-IN-1 is an inhibitor of CHK1 and CHK2, with anti-proliferative activities.

CHK-IN-1 can prevent DNA damage repair mechanism from arresting the cell cycle at the G2/M checkpoint[1].

References

[1]. Novel compounds and therapeutic use thereof for protein kinase inhibition. EP 2477496 A1

Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride synthesis

Synthesis of Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride from (S)-tert-butyl 3-((7-carbamoyl-2-(3-fluorophenyl)thieno[2,3-d]pyridazin-4-yl)amino)piperidine-1-carboxylate

Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride Preparation Products And Raw materials

Raw materials

(S)-tert-butyl 3-((7-carbamoyl-2-(3-fluorophenyl)thieno[2,3-d]pyridazin-4-yl)amino)piperidine-1-carboxylate

Preparation Products

Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride Suppliers

Global( 6)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7892	56
Fan De(Beijing) Biotechnology Co., Ltd.	15911056312	liming@bio-fount.com	China	9730	58
BOC Sciences	--	info@bocsci.com	USA	0	65
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
MedChemexpress LLC	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
Fan De(Beijing) Biotechnology Co., Ltd.	58
BOC Sciences	65
TargetMol Chemicals Inc.	58

Thieno[2,3-d]pyridazine-7-carboxamide, 2-(3-fluorophenyl)-4-[(3S)-3-piperidinylamino]-, hydrochloride CHK-IN-1 CHKIN1,CHK IN 1 1278405-51-8