VU 0409551
- CAS No.
- 1363281-27-9
- Chemical Name:
- VU 0409551
- Synonyms
- VU 0409551;JNJ-46778212;JNJ 46778212,JNJ46778212;JNJ-46778212, 10 mM in DMSO;[6,7-Dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](fluorophenyl)methanone;(4-Fluorophenyl)(2-(phenoxymethyl)-6,7-dihydrooxazolo[5,4-c]pyridin-5(4H)-yl)methanone;(4-fluorophenyl)-[2-(phenoxymethyl)-6,7-dihydro-4H-oxazolo[5,4-c]pyridin-5-yl]methanone;Methanone, [6,7-dihydro-2-(phenoxymethyl)oxazolo[5,4-c]pyridin-5(4H)-yl](4-fluorophenyl)-
- CBNumber:
- CB33354233
- Molecular Formula:
- C20H17FN2O3
- Molecular Weight:
- 352.36
- MDL Number:
- MOL File:
- 1363281-27-9.mol
| Product description | Number | Pack Size | Price |
| VU0409551 ≥98% (HPLC) | SML2783 | 5 mg | $73.62 |
| VU0409551 ≥98% (HPLC) | SML2783 | 25 mg | $372.4 |
| VU0409551 | 18042 | 1mg | $32 |
| VU0409551 | 18042 | 5mg | $93 |
| VU0409551 | 18042 | 10mg | $169 |
VU 0409551 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2783 | VU0409551 ≥98% (HPLC) | 1363281-27-9 | 5 mg | $73.62 | 2025-07-31 | Buy |
| Sigma-Aldrich | SML2783 | VU0409551 ≥98% (HPLC) | 1363281-27-9 | 25 mg | $372.4 | 2025-07-31 | Buy |
| Cayman Chemical | 18042 | VU0409551 | 1363281-27-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18042 | VU0409551 | 1363281-27-9 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 18042 | VU0409551 | 1363281-27-9 | 10mg | $169 | 2024-03-01 | Buy |
VU 0409551 Chemical Properties,Uses,Production
Uses
VU 0409551 is an mGlu5 allosteric modulator.
Biological Activity
VU0409551 (JNJ-46778212) is an orally available, potent and selective biased metabotropic glutamate receptor subtype 5 positive allosteric modulator (mGlu5 PAM). VU0409551 (JNJ-46778212) selectively potentiates mGlu5 coupling to Gaq-mediated signaling without modulation of NMDAR currents in hippocampal neurons. VU0409551 exhibits potent antipsychotic-like and cognition enhancing activity in animal models.
in vivo
In oral brain/plasma studies, JNJ-46778212 displays excellent CNS penetration[1]. JNJ-46778212 enhances NMDAR function and rescues long-term potentiation in hippocampal slices obtained from SR?/? mice. The administration of JNJ-46778212 to SR?/? mice reverses their deficits in several neuroplasticity signaling pathways and improves their contextual fear memory[2].
IC 50
mGlu5 Receptor: 260 nM (EC50)
storage
Store at +4°C
VU 0409551 Preparation Products And Raw materials
Raw materials
Preparation Products
VU 0409551 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32435 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 8510 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 646 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
