1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
- CAS No.
- 1837-91-8
- Chemical Name:
- 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
- Synonyms
- NSC 7908;JAK2 INHIBITOR II;BENZENE HEXABROMIDE;6-Hexabromocyclohexane;trans-α-Benzene hexabromide;1,2,3,4,5,6-Hexabromcyclohexan;1,2,3,4,5,6-HEXABROMOCYCLOHEXANE;1,2,3,4,5,6-hexabromo-cyclohexan;Cyclohexane, 1,2,3,4,5,6-hexabromo-;JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem
- CBNumber:
- CB3337703
- Molecular Formula:
- C6H6Br6
- Molecular Weight:
- 557.54
- MDL Number:
- MFCD00059127
- MOL File:
- 1837-91-8.mol
Melting point | 218.0 to 223.0 °C |
---|---|
storage temp. | Store at RT |
solubility | DMSO: soluble2mg/mL (clear solution, warmed) |
form | powder |
color | white to beige |
CAS DataBase Reference | 1837-91-8(CAS DataBase Reference) |
EPA Substance Registry System | Cyclohexane, 1,2,3,4,5,6-hexabromo- (1837-91-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H319 |
Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 |
Hazard Codes | Xn |
Risk Statements | 36/37/38-36-22 |
Safety Statements | 26-36/37/39 |
WGK Germany | 3 |
TSCA | Yes |
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 420132 | JAK2 Inhibitor II | 1837-91-8 | 25mg | $172 | 2024-03-01 | Buy |
Sigma-Aldrich | SML0455 | 1,2,3,4,5,6-Hexabromocyclohexane ≥98% (HPLC) | 1837-91-8 | 50mg | $127 | 2022-05-15 | Buy |
TCI Chemical | H0368 | 1,2,3,4,5,6-Hexabromocyclohexane | 1837-91-8 | 5g | $326 | 2021-12-16 | Buy |
TCI Chemical | H0368 | 1,2,3,4,5,6-Hexabromocyclohexane min. 97.0 % | 1837-91-8 | 1G | $109 | 2021-12-16 | Buy |
Alfa Aesar | J60853 | 1,2,3,4,5,6-Hexabromocyclohexane | 1837-91-8 | 1g | $99.65 | 2024-03-01 | Buy |
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Chemical Properties,Uses,Production
Uses
1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.
Definition
ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane.
Biological Activity
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.
storage
Room temperature
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Preparation Products And Raw materials
Raw materials
Preparation Products
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40068 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 | market03@meryer.com | China | 40240 | 62 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
View Lastest Price from 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2023-12-29 | 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
1837-91-8
|
US $101.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd |
- 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
1837-91-8
- US $101.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd