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H-8 DIHYDROCHLORIDE

H-8 DIHYDROCHLORIDE structure

CAS No.: 113276-94-1

Chemical Name:: H-8 DIHYDROCHLORIDE

Synonyms: H-8;H-8 HYDROCHLORIDE;H-8 DIHYDROCHLORIDE;H-8 dihydrochloride,98%;H8, dihydrochloride salt;H-8 dihydrochloride >98% (HPLC);H8 (hydrochloride),H 8 (hydrochloride);H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C;N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide;2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium

CBNumber:: CB3341825

Molecular Formula:: C12H17Cl2N3O2S

Molecular Weight:: 338.25

MDL Number:: MFCD00036962

MOL File:: 113276-94-1.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:20

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H-8 DIHYDROCHLORIDE Properties

Melting point	221-222℃ (methanol water )
storage temp.	2-8°C
solubility	ethanol: 25 mg/mL, clear, colorless
form	Lyophilized
color	White to Off-White
CAS DataBase Reference	113276-94-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3
HS Code	29334990

H-8 DIHYDROCHLORIDE price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M9656	H-8 dihydrochloride >98% (HPLC)	113276-94-1	5mg	$156	2024-03-01	Buy
Sigma-Aldrich	371958	H-8 dihydrochloride	113276-94-1	1mg	$167	2023-01-07	Buy
Cayman Chemical	10010249	H-8 (hydrochloride) ≥98%	113276-94-1	5mg	$37	2024-03-01	Buy
Cayman Chemical	10010249	H-8 (hydrochloride) ≥98%	113276-94-1	10mg	$59	2024-03-01	Buy
Cayman Chemical	10010249	H-8 (hydrochloride) ≥98%	113276-94-1	25mg	$116	2024-03-01	Buy

Product number	Packaging	Price	Buy
M9656	5mg	$156	Buy
371958	1mg	$167	Buy
10010249	5mg	$37	Buy
10010249	10mg	$59	Buy
10010249	25mg	$116	Buy

H-8 DIHYDROCHLORIDE Chemical Properties,Uses,Production

Description

The H series isoquinolinesulfonamide protein kinase (PK) inhibitors are widely used to block signaling pathways to elucidate mechanisms of cellular regulation and signal transduction. H-8, an isoquinolinesulfonamide protein kinase (PK) inhibitor, is a potent inhibitor of PKA and PKG and shows moderate inhibition for PKC and MLCK with K_i values of 1.2, 0.48, 15, and 68 μM, respectively. H-8 can disrupt transcriptional elongation by inhibiting cyclin C/Cdk8 and cyclin H/Cdk7/p36 CTD kinase activity with IC₅₀ values of 47 and 6.2 μM, respectively.

Chemical Properties

white to off-white crystalline solid

Uses

Active inhibitor of cyclic-nucleotide-dependent protein kinases.

Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

H-8 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

H-8 DIHYDROCHLORIDE Suppliers

Global( 72)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
J & K SCIENTIFIC LTD.	010-82848833 400-666-7788	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006608290; 18621169109	market03@meryer.com	China	40241	62
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32344	50

Supplier	Advantage
Alchem Pharmtech,Inc.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Mainchem Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chemsky（shanghai）International Co.,Ltd.	50

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5-IsoquinolinesulfonaMide,N-[2-(MethylaMino)ethyl]-, hydrochloride (1:2) H-8 DIHYDROCHLORIDE H-8 HYDROCHLORIDE H-8 N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE 2HCL N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE, DI-HCL SALT N-[2-(METHYLAMINO)ETHYL]-5-ISOQUINOLINESULFONAMIDE DIHYDROCHLORIDE N-(2-[METHYLAMINO]ETHYL)-5-ISOQUINOLINESULFONAMIDE HYDROCHLORIDE N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE-5-SULFONAMIDE DIHYDROCHLORIDE H-8 DIHYDROCHLORIDE POTENT INHIBITOR OF C H-8 dihydrochloride,98% N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamide H8, dihydrochloride salt 2-(5-isoquinolinylsulfonylamino)ethyl-methylammonium H-8 dihydrochloride >98% (HPLC) H8 (hydrochloride),H 8 (hydrochloride) 113276-94-1 C12H15N3O2S2HCl