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DL-Dithiothreitol

DL-Dithiothreitol structure

CAS No.: 27565-41-9

Chemical Name:: DL-Dithiothreitol

Synonyms: DTT;1,4-DITHIOTHREITOL;1,4-DITHIO-DL-THREITOL;Cleland's reagent;DTT-MBG;DITHIOTHRIETOL;(2R,3R)-1,4-dimercaptobutane-2,3-diol;DITT;DL-DTT;CGMP DTT

CBNumber:: CB3342918

Molecular Formula:: C4H10O2S2

Molecular Weight:: 154.25

MDL Number:: MFCD00004877

MOL File:: 27565-41-9.mol

Last updated:2024-03-26 17:16:27

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DL-Dithiothreitol Properties

Melting point	41-44 °C(lit.)
Boiling point	125-130 °C (2 mmHg)
Density	1.04 g/mL at 20 °C
refractive index	1.5200 (estimate)
Flash point	>230 °F
storage temp.	2-8°C
solubility	H₂O: 50 mg/mL, clear, colorless
form	Liquid
color	White
Water Solubility	Soluble
Merck	3376
CAS DataBase Reference	27565-41-9(CAS DataBase Reference)
EPA Substance Registry System	2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-(27565-41-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H302-H335-H315
Precautionary statements	P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes	Xn
Risk Statements	25-36/37/38-22
Safety Statements	26-45-36
WGK Germany	3
RTECS	EK1610000
F	3-10-16-23
HS Code	29309090
Toxicity	mouse,LD50,intramuscular,108mg/kg (108mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949.

DL-Dithiothreitol price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Medical Isotopes, Inc.	D1933	(+/-)-1,4-Dithiothreitol-d6	27565-41-9	100mg	$690	2021-12-16	Buy
Soltec Ventures	M112	(D,L)-1,4-Dithiothreitol,99.5+%,MolecularBiologyGrade MolecularBiologyGrade	27565-41-9	5gm	$31	2021-12-16	Buy

Product number	Packaging	Price	Buy
D1933	100mg	$690	Buy
M112	5gm	$31	Buy

DL-Dithiothreitol Chemical Properties,Uses,Production

Chemical Properties

White solid

Uses

DTT is a cell permeable protective agent for Thiol groups.

Uses

Reagent for the quantitative reduction of disulfide group. Prevents the oxidation of cholecystokinin during its extraction from brain and duodenal tissues. Cleavage of disulfide bonds in proteins.

Preparation

The preparation of DL-Dithiothreitol is as follows:To a round bottom flask was charged THPP (23mg, 0.11mmol, 1.10eq) and the basic buffer solution [tris-(hydroxymethyl)-aminomethane-CaCl2 based buffer; pH 8.00; 1.0mL]. The reaction mixture was stirred at room temperature for about 5 min and then to this homogenous solution was charged trans-4,5-Dihydroxy-1,2-dithiane (15.2mg, 0.10 mmol, 1.00eq.). The reaction mixture was stirred at room temperature until the reaction was complete (about 30 min). The product was readily identified by 1H-NMR analysis.

Definition

ChEBI: D-1,4-dithiothreitol is a 1,4-dithiothreitol. It is an enantiomer of a L-1,4-dithiothreitol.

Purification Methods

Crystallise DTT from ether and sublime it at 37o/0.005mm. It should be stored at 0o. [Beilstein 1 III 2360.]

DL-Dithiothreitol Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-(2-aminothiazol-5-ylthio)acetate DIHYDROLIPOIC ACID

DL-Dithiothreitol Suppliers

Global( 227)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Boquan Biotechnology Co., Ltd.	+86-18168774353	boquanshengwu003@boquansw.com	China	248	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
hebei hongtan Biotechnology Co., Ltd	+86-86-1913198-3935 +8617331935328	sales03@chemcn.cn	China	951	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	6992	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58

Supplier	Advantage
Jiangsu Boquan Biotechnology Co., Ltd.	58
Hebei Mojin Biotechnology Co., Ltd	58
Anhui Ruihan Technology Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58

View Lastest Price from DL-Dithiothreitol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-22	DL-Dithiothreitol 27565-41-9	US $30.00 / kg	1kg	98%	2000kg	hebei hongtan Biotechnology Co., Ltd
2023-11-20	DL-Dithiothreitol 27565-41-9	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-09-11	DL-Dithiothreitol 27565-41-9	US $80.00 / kg	1kg	99%	10000tons	Anhui Ruihan Technology Co., Ltd

DL-Dithiothreitol
27565-41-9
US $30.00 / kg
98%
hebei hongtan Biotechnology Co., Ltd

DL-Dithiothreitol
27565-41-9
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

DL-Dithiothreitol
27565-41-9
US $80.00 / kg
99%
Anhui Ruihan Technology Co., Ltd

DL-Dithiothreitol Spectrum

DL-Dithiothreitol(27565-41-9)MS DL-Dithiothreitol(27565-41-9)¹HNMR DL-Dithiothreitol(27565-41-9)¹³CNMR DL-Dithiothreitol(27565-41-9)IR1 DL-Dithiothreitol(27565-41-9)IR2

27565-41-9(DL-Dithiothreitol)Related Search:

3,3'-Thiodipropionic acid Phenothiazine 2,2'-Dithiosalicylic acid 1,4-Butanediol 2,3-Butanediol

threitol 2,2'-Thiodiethanol DL-Dithiothreitol L-DITHIOTHREITOL TRANS-4,5-DIHYDROXY-1,2-DITHIANE

1,4-BUTANEDITHIOL 3-Mercapto-1,2-propanediol Butanethiol L-THREITOL 1,4-DITHIOTHREITOL-1,1,2,3,4,4-D6

1-MERCAPTO-2-PROPANOL dl-dithiothreitol-d10 DL-THREITOL

1of4

DTT (RACEMIC) DL-THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE DL-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL DL-DTT DITHIOTHREITOL, 1,4- DITT DL-2,3-DIHYDROXY-1,4-BUTANEDITHIOL DL-1,4-DIMERCAPTO-2,3-BUTANEDIOL CGMP DTT CLELAND REAGENT RACEMIC CLELAND'S REAGENT, IMMOBILIZED CLELAND'S REDUCTACRYL(TM) REAGENT 2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)- (2S,3S:2R,3R)-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL 1,4-DITHIOTHREITHOL RAC-CLELAND'S REAGENT (R,R)-DITHIOTHREITOL (R,R)-1,4-DIMERCAPTO-2,3-BUTANEDIOL THREO-2,3-DIHYDROXY-1,4-DITHIOBUTANE THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE SPUTOLYSIN(R) REAGENT 1,4-dimercapto-,(r*,r*)-(+-)-3-butanediol 1,4-dimercapto-,(theta,theta)-(+/-)-3-butanediol 4-dimercapto-3-butanediodl-threo-1 4-dithio-dl-threito rac-dithiothreitol 1 4-DITHIO-DL-THREITOL(+4℃) Di-dithiothreitol DTT(1,4-Dithiothreitol 1,4-Dithio-DL-threitol≥ 99% (Titration) 1,4-dithio-dl-threitol sol. Clelands REDUCTACRYL dithiothreitol (dtt) sequencing grade dithiothreitol molecular biology*reagent DithiothreitollelandsReagenz Dithithreitol DL-Dithothreitol (R*,R*)-(±)-1,4-dimercaptobutane-2,3-diol 2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)-()-OR,DITHIOTHREITOL Dtt(Dl-Dithiothreitol) (±)-1,4-Dithiothreitol-D6 DL-DITHIOTHREITOL,ELECTROPHORESISGRADE (+/-)-1,4-Dithio-D-threitol D-Dithiothreitol, (2S,3S)-threo-1,4-Dimercapto-2,3-butandiol DL-DITHIOTHREITOL extrapure 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)- DL-1,4-Dimercapto-2,3-dihydroxybutane threo-2,3-Dihydroxy-1,4-butanedithiol DL-Dithiothreitol [for Electrophoresis] DL-1,4-Dithiothreitol ,98% DITHIOTHREITOL RESEARCH GRADE Dithiothreitol in Ethyl acetate@1000 μg/mL in Ethyl acetate DTT-MBG DITHIOTHRIETOL 1,4-DITHIO-DL-THREITOL 1,4-DITHIOTHREITOL (2R,3R)-1,4-dimercaptobutane-2,3-diol Cleland's reagent