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HYDROXYLAMINE

Description References
HYDROXYLAMINE
HYDROXYLAMINE structure
CAS No.
7803-49-8
Chemical Name:
HYDROXYLAMINE
Synonyms
NH2OH;FH-50;FH-50TM;Oxyammonia;Oxammonium;Hydroxyamine;azinous acid;HYDROXYLAMINE;HYDROXYLAMINE Joyce;hydroxylaminefree-base
CBNumber:
CB3345090
Molecular Formula:
H3NO
Formula Weight:
33.03
MOL File:
7803-49-8.mol

HYDROXYLAMINE Properties

Melting point:
7°C
Boiling point:
>100 °C
Density 
1.078 g/mL at 25 °C
vapor pressure 
9 mm Hg ( 40 °C)
refractive index 
n20/D 1.393
RTECS 
NC2975000
storage temp. 
Store below +30°C.
form 
white flakes or needles
pka
pK (20°) 7.97
Water Solubility 
Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform.
Merck 
13,4853
Stability:
Stable. Incompatible with oxidizing agents, potassium dichromate, chromium trioxide, zinc, calcium, copper, sodium, ammonia, carbonyls, phosphorus halides, pyridine, hypochlorites.
InChIKey
AVXURJPOCDRRFD-UHFFFAOYSA-N
CAS DataBase Reference
7803-49-8(CAS DataBase Reference)
EWG's Food Scores
5-7
FDA UNII
2FP81O2L9Z
NIST Chemistry Reference
Hydroxylamine(7803-49-8)
EPA Substance Registry System
Hydroxylamine (7803-49-8)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS07,GHS08,GHS09
Signal word  Danger
Hazard statements  H290-H302+H312-H315-H317-H318-H335-H351-H371-H373-H400-H302-H313
Precautionary statements  P201-P405-P501a-P260-P273-P280-P305+P351+P338-P308+P311-P261
Hazard Codes  Xn,N
Risk Statements  5-22-37/38-41-43-48/22-50-40-21/22
Safety Statements  23-26-36/37/39-47-61-22-46
RIDADR  UN 3082 9/PG 3
WGK Germany  3
4.8
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  28251090
Toxicity LD50 i.p. in mice: 1.83 mmol/kg (Smith, Layne)
NFPA 704
0
2 3

HYDROXYLAMINE price More Price(10)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.14441 Hydroxylamine (50% solution in water) for synthesis 7803-49-8 100 mL $28.21 2021-03-22 Buy
Sigma-Aldrich 438227 Hydroxylamine solution 50 wt. % in H2O 7803-49-8 50ml $35.4 2021-03-22 Buy
Sigma-Aldrich 438227 Hydroxylamine solution 50 wt. % in H2O 7803-49-8 250ml $81.8 2021-03-22 Buy
Sigma-Aldrich 8.14441 Hydroxylamine (50% solution in water) for synthesis 7803-49-8 500 mL $86.49 2021-03-22 Buy
Alfa Aesar B22202 Hydroxylamine 50% aq. soln. 7803-49-8 100ml $39.1 2020-06-24 Buy

HYDROXYLAMINE Chemical Properties,Uses,Production

Description

Hydroxylamine is the hydroxyl derivative of ammonia. Hydroxylamine is used as a nucleophile in aromatic substitution reactions and as a reducing agent. By the reaction with aldehydes, hydroxylamine forms oximes, which are intermediates in the commercial production of polyamide plastics. Some hydroxylamine converted oximes are used in smaller amounts as pharmaceuticals, pesticides, and varnishes to prevent formation of a skin. With it is reduction ability, hydroxylamine is used as an antioxidant in photographic developers, to stabilize polymerization monomers, and to reduce Cu2+ in the dyeing of acrylic fibers. Hydroxylamine can be converted into hydroxylamine-O-sulphonic acid, which is a good aminating agent. Hydroxylamine can also be used as an intermediate in nitrification. It is further used in semiconductor industry in the cleaning formations, such as for aluminum interconnect.

References

  1. Stephen A. Lawrence, Amines: Synthesis, Properties and Applications, 2004, ISBN 0521782848
  2. Howard Lees, Hydroxylamine as an intermediate in nitrification, Nature, 1951, vol. 169, 156-157
  3. Egon Wiberg and Nils Wiberg, Inorganic Chemistry, 2001, ISBN 0123526515
  4. https://www.britannica.com/science/hydroxylamine
  5. Karen A. Reinhardt and Richard F. Reidy, Handbook for Cleaning for Semiconductor Manufacturing: Fundamentals and Applications, 2011, ISBN 9780470625958

Description

Hydroxylamine was first synthesized by Wilhem Clemens Lossen in 1865 in the laboratory of Wilhelm Heinrich Heintz while working in Halle. The Lossen synthesis originally generated hydroxylamine in aqueous solution. Anhydrous hydroxylamine was prepared later by Lobry de Bruyn and Crismer in 1891. The free base is extremely volatile, and industrial-scale production has been fraught with problems, including large explosions at facilities in the United States and Japan. Much of the hydroxylamine produced and transported is in salt form or as a dilute aqueous solution.

Chemical Properties

slightly yellow liquid

Physical properties

White crystalline solid; orthogonal plates or needles; unstable; density 1.21g/cm3at 20°C; melts at 33°C; vaporizes at 58°C; very soluble in water, liquidammonia and lower alcohols; sparingly soluble in most other organic solvents;decomposes in hot water; pKa5.94 at 25°C.

Uses

Reducing agent used in photographic processing, leather tanning, manufacturing of nylon and other polymers; as a stabilizer for natural rubber; to prevent the development of objectionable tastes and odors during the refining of fatty materials.

Uses

Hydroxylamine is used as a reducing agent in photography, in synthetic and analytical chemistry, as an antioxidant for fatty acids and soaps, and as a dehairing agent for hides. In addition, hydroxylamine is used in the production of cyclohexanone oxime, an isomer of caprolactam, which is an intermediate in the production of nylon-6. In the semiconductor industry, hydroxylamine can be a component of a solution that dissolves a photoresist following lithography. Hydroxylamine can also be used to selectively cleave asparaginyl-glycine peptide bonds.

Uses

Reducing agent, organic synthesis.

Definition

ChEBI: The simplest hydroxylamine, consisting of ammonia bearing a hydroxy substituent. It is an intermediate in the biological nitrification by microbes like bacteria.

Preparation

Hydroxylamine is unstable as a free base. It is prepared from hydroxy-lamine hydrochloride, NH2OH?HCl, which is obtained by electrolytic reduc-tion of ammonium chloride solution. The hydrochloride undergoes alkalinedecomposition to hydroxylamine, which is collected by vacuum distillation.

Definition

hydroxylamine: A colourless solid,NH2OH, m.p. 33°C. It explodes onheating and may be employed as anoxidizing agent or reducing agent. Itis made by the reduction of nitratesor nitrites, and is used in makingnylon. With aldehydes and ketones itforms oximes.

General Description

Odorless white crystalline solid. Sinks and mixes with water.

Air & Water Reactions

Decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. Reacts with water or steam to produce heat and corrosive liquids.

Reactivity Profile

HYDROXYLAMINE is a white solid, thermally unstable, decomposes rapidly at room temperature or when dissolved in hot water by internal oxidation-reduction. HYDROXYLAMINE should be stored below 10° C [Bailar, 1973, vol. 2, p. 272]. Explosive reaction with strong oxidizers (chromium trioxide, potassium dichromate) or powdered zinc upon heat. Reaction with zinc or calcium produces explosive bishydroxylamides. HYDROXYLAMINE ignites on contact with cupric sulfate, alkali metals (sodium, potassium), oxidants (e.g., barium oxide, barium peroxide, lead dioxide, potassium permanganate, chlorine), phosphorus trichloride and pentachloride. HYDROXYLAMINE reacts vigorously with hypochlorites, pyridine, carbonyls [Sax, 9th ed., 1996, p. 1875]. On contact with organic materials in thin layer (e.g., crystals on filter paper), HYDROXYLAMINE may ignite spontaneously in air. HYDROXYLAMINE explodes when heated above 70° C [Brauer, 1963, vol. 1, p. 502]. During a distillation process, an explosion occurred. Potassium hydroxide is thought to be involved in the explosion. Employees in the plant complained of chest pains and suffered chemical burns. Five people were killed by the explosion.

Hazard

Decomposes rapidly at room temperature, violently when heated, detonates in flame-heated test tube. Irritant to tissue.

Health Hazard

INHALATION: Moderately toxic by inhalation and oral routes with the following symptoms possible: headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported. EYES: Corrosive - highly irritating. SKIN: Irritating or corrosive to skin. INGESTION: Moderately toxic by inhalation and oral routes with the following symptoms possible; headache, vertigo, tinnitus, dyspnea, nausea and vomiting, cyanosis, proteinuria and hematuria, jaundice, restlessness, and convulsion. Methemoglobinemia has been reported.

Contact allergens

Hydroxylamine and its salts are used in various branches of industry, as reducing agents in color film developers or as reagents in laboratories.

Carcinogenicity

Carcinogenicity of hydroxylamine and its salts has not been demonstrated. Several studies have shown a decreased incidence of spontaneous mammary tumors in mice exposed to the sulfate and hydrochloride.3–7 There was some indication of an increase in the incidence of spontaneous mammary tumors when the sulfate was administered to older animals whose mammary glands were already well developed.

Environmental Fate

The large-scale production and use of hydroxylamine may result in its release to the environment through various waste streams. Hydroxylamine will exist solely as a vapor in the ambient atmosphere, and will be degraded in the atmosphere by reaction with photochemically produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 18 h.
Abiotic degradation of hydroxylamine by photochemically produced peroxy radicals is an important environmental fate process in surface waters, with the half-life of the reaction measured at approximately 2 h. An estimated bioconcentration factor of 3 suggests that the potential for bioconcentration in aquatic organisms is low. If released terrestrially, hydroxylamine will most likely exist in its protonated form due to its pKa of 5.94; the protonated form is nonvolatile. Koc estimates of 14 for hydroxylamine suggest that it may have very high mobility in soil.

Purification Methods

Crystallise it from n-butanol at -10o, collect it by vacuum filtration and wash it with cold diethyl ether. Harmful vapours. [Hurd Inorg Synth I 87 1939, Semon in Org Synth Coll Vol I 318 1932.]

Toxicity evaluation

Hydroxylamine acts as a reducing agent when absorbed systemically, producing methemoglobin and the formulation of Heinz bodies in the blood. It can induce hemolytic anemia. It inhibits platelet aggregation and is a nitric oxide vasodilator. Oxylamines such as hydroxylamine and methoxylamine disturb DNA replication and act as potent mutagens, causing nucleotide transition from one purine to another or one pyrimidine to another.
Allergic reactions of the skin following dermal exposure to hydroxylamine resemble contact eczema, or possibly urticaria of Quincke’s edema. The pathogenesis of this reaction appears to be mediated by a delayed type T-lymphocyte reaction.

HYDROXYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products


HYDROXYLAMINE Suppliers

Global( 132)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5882 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
86-021-61999440
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Hubei Ipure Biology Co., Ltd
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HONG KONG IPURE BIOLOGY CO.,LIMITED
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Wuhan Monad Medicine Tech Co.,LTD
18771942761 02768782018
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AFINE CHEMICALS LIMITED
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008657185134895 info@afinechem.com CHINA 15559 58

View Lastest Price from HYDROXYLAMINE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 HYDROXYLAMINE
7803-49-8
US $10.00 / KG 100g 99% 1000MT/Month Wuhan wingroup Pharmaceutical Co., Ltd
2021-08-31 Hydroxylamine
7803-49-8
US $10.00 / KG 1KG 99.99% 20 tons/month Wuhan Monad Medicine Tech Co.,LTD
2021-08-17 HYDROXYLAMINE
7803-49-8
US $10.00 / KG 100KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.

HYDROXYLAMINE Spectrum


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