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Diethyl phthalate

Diethyl phthalate
Diethyl phthalate structure
Chemical Name:
Diethyl phthalate
Amozol;Anozol;Neantine;PHTHALOL;Solvanol;NSC 8905;estol1550;placidole;unimollda;Estol 1550
Molecular Formula:
Formula Weight:
MOL File:

Diethyl phthalate Properties

Melting point:
−3 °C(lit.)
Boiling point:
298-299 °C(lit.)
1.12 g/mL at 25 °C(lit.)
vapor density 
7.66 (vs air)
vapor pressure 
1 mm Hg ( 100 °C)
refractive index 
n20/D 1.502(lit.)
Flash point:
>230 °F
storage temp. 
Practically insoluble in water, miscible with ethanol (96 per cent).
Specific Gravity
APHA: ≤15
explosive limit
0.75%, 187°F
Water Solubility 
1 g/L (20 ºC)
Exposure limits
TLV-TWA air 5 mg/m3 (ACGIH). .
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, alkalies.
CAS DataBase Reference
84-66-2(CAS DataBase Reference)
NIST Chemistry Reference
Diethyl phthalate(84-66-2)
EPA Substance Registry System
1,2-Benzenedicarboxylic acid, diethyl ester(84-66-2)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
  • NFPA
Safety Statements  24/25
WGK Germany  2
RTECS  TI1050000
Autoignition Temperature 854 °F
HS Code  29173400
Hazardous Substances Data 84-66-2(Hazardous Substances Data)
Toxicity LD50 i.p. in rats: 5.06 ml/kg (Singh)
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

NFPA 704

Diamond Hazard Value Description
Flammability   1 Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia)
Instability   0 Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)

(NFPA, 2010)

Diethyl phthalate price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 524972 Diethyl phthalate 99.5% 84-66-2 1l $42.8 2018-11-13 Buy
Sigma-Aldrich 1193505 Diethyl Phthalate United States Pharmacopeia (USP) Reference Standard 84-66-2 200mg $401 2018-11-13 Buy
TCI Chemical P0296 Diethyl Phthalate >99.0%(GC) 84-66-2 25mL $14 2018-11-22 Buy
TCI Chemical P0296 Diethyl Phthalate >99.0%(GC) 84-66-2 500mL $17 2018-11-22 Buy
Alfa Aesar A17529 Diethyl phthalate, 99% 84-66-2 250g $20.5 2018-11-13 Buy

Diethyl phthalate Chemical Properties,Uses,Production

Chemical Properties

Diethyl phthalate is a colourless, odourless, and oily liquid. It is miscible with ethanol and ethyl ether. Diethyl phthalate is soluble in acetone, benzene, carbon tetrachloride, alcohols, ketones, esters, and aromatic hydrocarbons and partly miscible with aliphatic solvents. Diethyl phthalate, when exposed to heat, decomposes and emits acrid smoke and irritating fumes. It is incompatible with strong oxidisers, strong acids, nitric acid, permanganates, and water and attacks some forms of plastics. Diethyl phthalate is produced in the reaction of phthalic anhydride with ethanol in the presence of concentrated sulphuric acid catalyst.

Chemical Properties

Diethyl phthalate is a clear, colorless, oily liquid. It is practically odorless, or with a very slight aromatic odor and a bitter, disagreeable taste.


A phthalate metabolite with genotoxic effect.




Ethyl phthalate used in manufacture of celluloid; solvent for cellulose acetate in manufacture of varnishes and dopes; denaturing alcohol. Vehicle for fragrance and cosmetic ingredients.


ChEBI: The diethyl ester of benzene-1,2-dicarboxylic acid.

Production Methods

Diethyl phthalate is produced by the reaction of phthalic anhydride with ethanol in the presence of sulfuric acid.

General Description

A clear, colorless liquid without significant odor. More dense than water and insoluble in water. Hence sinks in water. Primary hazard is to the environment. Spread to the environment should be immediately stopped. Easily penetrates soil, contaminates groundwater and nearby waterways. Flash point 325°F. Severely irritates eyes and mildly irritates skin. Used in the manufacture of perfumes, plastics, mosquito repellents and many other products.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Diethyl phthalate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Can generate electrostatic charges. [Handling Chemicals Safely 1980. p. 250].

Health Hazard

Symptoms unlikely from any form of exposure.

Health Hazard

Diethyl phthalate exhibited low to very lowacute toxicity in laboratory animals. Inges tion produced somnolence and hypotension.Inhalation of its vapors may result in lacrima tion, coughing, and irritation of the throatin humans. The oral LD50 value in mice is6170 mg/kg. Diethyl phthalate administeredto pregnant rats at 5% concentration in thefeed showed no adverse effect upon embryoor fetal growth, viability, or the incidence ofmalformations (Price et al. 1988).

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors of unburned chemical may form in fire.

Pharmaceutical Applications

Diethyl phthalate is used as a plasticizer for film coatings on tablets, beads, and granules at concentrations of 10–30% by weight of polymer.
Diethyl phthalate is also used as an alcohol denaturant and as a solvent for cellulose acetate in the manufacture of varnishes and dopes. In perfumery, diethyl phthalate is used as a perfume fixative at a concentration of 0.1–0.5% of the weight of the perfume used.

Contact allergens

This plasticizer increases the fexibility of plastics. It is also contained in deodorant formulations, perfumes, emollients, and insect repellents. It can cross-react with dimethyl phthalate.

Safety Profile

Poison by intravenous route. Moderately toxic by ingestion, subcutaneous, and intraperitoneal routes. Human systemic effects by inhalation: lachrymation, respiratory obstruction, and other unspecified respiratory system effects. An eye irritant and systemic irritant by inhalation. An experimental teratogen. Other experimental reproductive effects. Narcotic in hgh concentrations. Combustible when exposed to heat or flame. To fight fire, use water spray, mist, foam. When heated to decomposition it emits acrid smoke and irritating fumes.


Diethyl phthalate is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. However, if consumed in large quantities it can act as a narcotic and cause paralysis of the central nervous system.
Although some animal studies have suggested that high concentrations of diethyl phthalate may be teratogenic, other studies have shown no adverse effects.
LD50 (guinea pig, oral): 8.6g/kg
LD50 (mouse, IP): 2.7g/kg
LD50 (mouse, oral): 6.2g/kg
LD50 (rat, IP): 5.1g/kg
LD50 (rat, oral): 8.6g/kg


Diethyl phthalate is stable when stored in a well-closed container in a cool, dry place.

Purification Methods

Wash the ester with aqueous Na2CO3, then distilled water, dry (CaCl2), and distil it under reduced pressure. Store it in a vacuum desiccator over P2O5. [Beilstein 9 IV 3172.]


Incompatible with strong oxidizing materials, acids, and permanganates.

Regulatory Status

Included in the FDA Inactive Ingredients Database (oral capsules, delayed action, enteric coated, and sustained action tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Diethyl phthalate Preparation Products And Raw materials

Raw materials

Preparation Products

Diethyl phthalate Suppliers

Global( 290)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32606 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 CHINA 2548 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070; CHINA 3015 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1747 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6402 58
Chemwill Asia Co.,Ltd.
86-21-51861608;;; CHINA 24093 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254 CHINA 20177 58
Jinan Finer Chemical Co., Ltd
+86-531-88989539 CHINA 940 58
Haihang Industry Co.,Ltd
+86 531 8582 1093 CHINA 4696 58

View Lastest Price from Diethyl phthalate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-22 Diethyl phthalate
US $1.00 / kg 1kg 99% Customized career henan chemical co

Diethyl phthalate Spectrum

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