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Riluzole

Description References
Riluzole
Riluzole structure
CAS No.
1744-22-5
Chemical Name:
Riluzole
Synonyms
BF-37;RILUTEK;RILUZOLE;RP-54274;PK 26124;Rilutek (TN);Prestwick-03A08;Riluzole(Rilutek);BUTTPARK 13\02-09;Riluzole (200 mg)
CBNumber:
CB3353226
Molecular Formula:
C8H5F3N2OS
Formula Weight:
234.2
MOL File:
1744-22-5.mol

Riluzole Properties

Melting point:
116-118°C
storage temp. 
Store at RT
solubility 
DMSO: ≥25 mg/mL
form 
solid
color 
white
Merck 
14,8223
InChIKey
FTALBRSUTCGOEG-UHFFFAOYSA-N
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H300-H315-H319-H335
Precautionary statements  P301+P310-P261-P280a-P301+P310a-P305+P351+P338-P405-P501a
Hazard Codes  T,Xi
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  DL2830000
Hazard Note  Irritant
HazardClass  IRRITANT
HazardClass  6.1
PackingGroup  II
HS Code  29342000
Toxicity LD50 in mice (mg/kg): 46 i.p.; 67 orally (Mizoule)

Riluzole price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 557324 Riluzole 1744-22-5 50mg $119 2018-11-20 Buy
Sigma-Aldrich 1604337 Riluzole United States Pharmacopeia (USP) Reference Standard 1744-22-5 200mg $423.85 2018-11-13 Buy
TCI Chemical A2423 2-Amino-6-(trifluoromethoxy)benzothiazole >98.0%(HPLC)(T) 1744-22-5 5g $62 2018-11-22 Buy
TCI Chemical A2423 2-Amino-6-(trifluoromethoxy)benzothiazole >98.0%(HPLC)(T) 1744-22-5 25g $214 2018-11-22 Buy
Alfa Aesar H61328 2-Amino-6-(trifluoromethoxy)benzothiazole, 98% 1744-22-5 5g $80.4 2018-11-13 Buy

Riluzole Chemical Properties,Uses,Production

Description

Riluzole belongs to the derivative of benzothiazole with neuroprotective, potential anti-depressant and anxiolytic activities, which is used in the treatment of a certain type of nerve disease called amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease). It is effective to delay the onset of ventilator-dependence or tracheostomy in selected patients, slow down the deterioration of this disease and probably prolong survival by approximately two to three months. Besides, studies have proved that riluzole has anti-depressant activity for refractory depression and serves as an anxiolytic in the treatment of obsessive-compulsive disorder and generalized anxiety disorder.
However, riluzole does not cure the ALS and reverse nerve damage or muscle weakness. It is believed to function as an inhibitor of a natural substance called glutamate. It helps protect the nerves in the brain and spinal cord from too much of glutamate which may contribute to the nerve damage. Riluzole is available in both tablet and liquid form. The liquid formulation may be more suitable for patients with swallowing difficulties.

References

https://en.wikipedia.org/wiki/Riluzole
http://www.medicinenet.com/riluzole_oral_tablets/article.htm
https://pubchem.ncbi.nlm.nih.gov/compound/5070#section=Top

Description

Rilutek was launched in Germany, the UK and US (orphan drug status) for treatment of amyotrophic lateral sclerosis (ALS) and is the first drug approved for this indication. A one step synthesis from 4-(trifluoromethoxy)aniline provides a supply of the compound. The source of its neuroprotective and anticonvulsant activity is not clearly understood. It antagonizes excitatory amino acids and blocks presynaptic release of glutamate, is an antagonist of NMDA-induced acetylcholine release and inhibited glutamate and quisqualate induced increases in cGMP but does not bind to NMDA or Kainic receptors. Rilutek has no affinity for glutamate, GABAbenzodiazepine, glycine and adenosine receptors. It easily crosses the blood brain barrier and depresses glutamatergic neurotransmission, stabilizes voltagedependent Na channels in their inactive form and activates G-protein dependent processes.

Chemical Properties

White Crystalline Solid

Originator

Rhone-Poulenc Rorer (France)

Uses

A neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

Uses

anticonvulsant, glutamate release inhibitor, anti-ALS

Uses

Labeled Riluzole, intended for use as an internal standard for the quantification of Riluzole by GC- or LC-mass spectrometry.

Uses

A neuroprotective agent. A glutamate release inhibitor. An anticonvulsant

brand name

Rilutek (Sanofi Aventis).

Biological Activity

Novel psychotropic agent with anticonvulsant, hypnotic, anxiolytic, anti-ischemic and anesthetic properties. Riluzole is able to act as a glutamate release inhibitor, blocks voltage-dependent Na + channels and inhibits GABA uptake by striatal synaptosomes.

Riluzole Preparation Products And Raw materials

Raw materials

Preparation Products


Riluzole Suppliers

Global( 241)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Jinan Shengqi pharmaceutical Co,Ltd
86+18663751872
christine@shengqipharm.com CHINA 556 58
Hebei Aicrowe Biotech Co., Ltd
0311-66855331
aicrowe@kf-chem.com CHINA 315 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1817 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24191 60
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1017 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23980 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6372 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
info@longyupharma.com CHINA 690 58

View Lastest Price from Riluzole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-05-14 white Riluzole CAS NO.1744-22-5 kf-wang(at)kf-chem.com
1744-22-5
US $10.00 / g 1g 99.6% 20000 Hebei Aicrowe Biotech Co., Ltd
2019-05-15 Riluzole
1744-22-5
US $1.00 / KG 1g 99% 500 Hebei Aicrowe Biotech Co., Ltd
2019-08-23 Riluzole
1744-22-5
US $200.00 / KG 1KG 98 100kg Jinan Shengqi pharmaceutical Co,Ltd

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