FHBANDDJQJAZOQ-CQSZACIVSA-N
- CAS No.
- 1236858-52-8
- Chemical Name:
- FHBANDDJQJAZOQ-CQSZACIVSA-N
- Synonyms
- PF-04449613;PF 04449613,PF04449613;PF-04449613 >=98% (HPLC);FHBANDDJQJAZOQ-CQSZACIVSA-N;(R)-6-(1-(3-Phenoxyazetidin-1-yl)ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4(5H)-one;1,5-Dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-4H-pyrazolo[3,4-d]pyrimidin-4-one;4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-6-[(1R)-1-(3-phenoxy-1-azetidinyl)ethyl]-1-(tetrahydro-2H-pyran-4-yl)-
- CBNumber:
- CB33544081
- Molecular Formula:
- C21H25N5O3
- Molecular Weight:
- 395.45
- MDL Number:
- MFCD28963901
- MOL File:
- 1236858-52-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
FHBANDDJQJAZOQ-CQSZACIVSA-N price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0349 | PF-04449613 ≥98% (HPLC) | 1236858-52-8 | 5mg | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0349 | PF-04449613 ≥98% (HPLC) | 1236858-52-8 | 25mg | $464 | 2024-03-01 | Buy |
| Tocris | 5915 | PF04449613 ≥98%(HPLC) | 1236858-52-8 | 10 | $247 | 2021-12-16 | Buy |
| TRC | P294110 | PF04449613 | 1236858-52-8 | 1mg | $90 | 2021-12-16 | Buy |
FHBANDDJQJAZOQ-CQSZACIVSA-N Chemical Properties,Uses,Production
Uses
PF 04449613 (cas# 1236858-52-8) is a useful research chemical. Potent PDE9 inhibitor.
Biochem/physiol Actions
PF-04449613 is a potent and selective cGMP-competitive PDE9A inhibitor (IC50 = 24 nM; IC50 >800 nM against other PDE members), displaying more than 1000-fold selectivity over the majority of 79 non-PDE targets investigated with the exception of cytochrome P450 2C19 (IC50 = 1600 nM), dopamine transporter (Ki = 110 nM), μ-opioid receptor (Ki = 3500 nM), and sodium channel binding site 2 (Ki = 470 nM). PF-4449613 is shown to effectively increase cGMP levels in brain (1-10 mg/kg s.c.; mice) and CSF (1-32 mg/kg s.c.; rats and cynomolgus macaques) in vivo with good brain penetration (brain/plasma ratio of 0.8 in mice). PF-04449613 is effective against D-amphetamine-induced auditory gating deficit (by 43% with 1 mg/kg PF-04449613 s.c.; 1 mg/kg AMP i.v.) and transverse aortic constriction-caused cardiac dysfunction (30 mg/kg/12 h p.o.) in mice in a NOS-independent manner.
storage
Store at -20°C
FHBANDDJQJAZOQ-CQSZACIVSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
FHBANDDJQJAZOQ-CQSZACIVSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 3977 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | 18143011203 | ET-market@chemextension.com | China | 30431 | 58 |