HVRLZEKDTUEKQH-NEGCSKJWSA-N
- CAS No.
- 1331635-21-2
- Chemical Name:
- HVRLZEKDTUEKQH-NEGCSKJWSA-N
- Synonyms
- HVRLZEKDTUEKQH-NEGCSKJWSA-N;[2H3]- Olopatadine Hydrochloride;2-[(11Z)-11-[3-[methyl(trideuteriomethyl)amino]propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid
- CBNumber:
- CB33564603
- Molecular Formula:
- C21H21ClD3NO3
- Molecular Weight:
- 376.891645334
- MDL Number:
- MOL File:
- 1331635-21-2.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| NFPA 704 |
|
HVRLZEKDTUEKQH-NEGCSKJWSA-N price More Price(1)
HVRLZEKDTUEKQH-NEGCSKJWSA-N Chemical Properties,Uses,Production
Uses
Labelled Olopatadine. Dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic.
Biological Activity
Olopatadine-d3 is intended for use as an internal standard for the quantification of olopatadine by GC- or LC-MS. Olopatadine is a histamine H1 receptor antagonist (Ki =41 nM).1 It is 1,059- and 4,177-fold selective for histamine H1 over H2 and H3 receptors, respectively. Olopatadine inhibits histamine-induced phosphoinositide turnover in isolated human conjunctival epithelial cells, isolated human corneal fibroblasts, and human trabecular meshwork (TM3) cells (IC50s = 9.5, 19, and 39.9 nM, respectively). In vivo, olopatadine inhibits passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and IgG1-mediated bronchoconstriction in ovalbumin-sensitized guinea pigs (ED50 = 30 μg/kg).2 Formulations containing olopatadine have been used in the treatment of allergic rhinitis and conjunctivitis, as well as in the treatment of itch in patients with well-controlled urticaria.
References
1.Sharif, N.A., Xu, S.X., and Yanni, J.M.Olopatadine (AL-4943A): Ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitisJ. Ocul. Pharmacol. Ther.12(4)401-407(1996) 2.Ohshima, E., Otaki, S., Sato, H., et al.Synthesis and antiallergic activity of 11-(aminoalkylidene)-6,11-dihydrodibenz[b,e]oxepin derivativesJ. Med. Chem.35(11)2074-2084(1992)
HVRLZEKDTUEKQH-NEGCSKJWSA-N Preparation Products And Raw materials
Raw materials
Preparation Products
HVRLZEKDTUEKQH-NEGCSKJWSA-N Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Changzhou Xianglong Pharmaceutical Technology Co., LTD | 18661161657 | yaoxiangqiu2021@163.com | China | 10066 | 58 |
| ChemeGen 中国 | 18818260767 | sales@chemegen.com | China | 6975 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Supplier | Advantage |
|---|---|
| Energy Chemical | 58 |
| Changzhou Xianglong Pharmaceutical Technology Co., LTD | 58 |
| ChemeGen 中国 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
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