ChemicalBook >> CAS DataBase List >>ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

CAS No.
307519-88-6
Chemical Name:
ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate
Synonyms
NMDI14;NMDI14 >=97% (HPLC);inhibit,Inhibitor,NMDI14,NMDI-14,NMDI 14;ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate;3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester
CBNumber:
CB33589260
Molecular Formula:
C21H25N3O4S
Molecular Weight:
415.51
MDL Number:
MFCD02073967
MOL File:
307519-88-6.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:03

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Properties

Boiling point 658.8±55.0 °C(Predicted)
Density 1.250±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO : ≥ 25 mg/mL (60.17 mM)
pka 13.42±0.40(Predicted)
form powder
color white to beige

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1538 NMDI14 ≥97% (HPLC) 307519-88-6 5MG $153 2023-06-20 Buy
Sigma-Aldrich SML1538 NMDI14 ≥97% (HPLC) 307519-88-6 25MG $530 2023-06-20 Buy
Product number Packaging Price Buy
SML1538 5MG $153 Buy
SML1538 25MG $530 Buy

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Chemical Properties,Uses,Production

Uses

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:

  • to study its effects on differentiating cardiomyocytes
  • to study its effects on zebrafish pdzk1 gene-knockout embryos
  • to analyze its effects on the apoptosis of colorectal cancer cells

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Suppliers

Global( 25)Suppliers
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TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific
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Wuhan Jingkang en Biomedical Technology Co., Ltd
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Zhengzhou HSH Science & Technology Co., Ltd. 0371-55932928 18937192232 1282296214@qq.com China 498 55
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
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ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8014 62
Twochem Co.Ltd. 021-58111628 15800915896 sales@twochem.com China 1788 58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd. 18081075745 chemflowtech@sina.com China 1886 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate NMDI14 3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester NMDI14 >=97% (HPLC) inhibit,Inhibitor,NMDI14,NMDI-14,NMDI 14 307519-88-6