3,4,5-Trichloronitrobenzene
- CAS No.
- 20098-48-0
- Chemical Name:
- 3,4,5-Trichloronitrobenzene
- Synonyms
- Anagrelide Impurity 11;3,4,5-Trichlornitrobenzol;3,4,5-DICHLORONITROBENZENE;3,4,5-TRICHLORONITROBENZENE;1,2,3-TRICHLORO-5-NITROBENZNE;1,2,3-TRICHLORO-5-NITROBENZENE;5-NITRO-1,2,3-TRICHLOROBENZENE;3,4,5-trichloro-1-nitrobenzene;Benzene,1,2,3-trichloro-5-nitro-;1,2,3-Trichloro-5-nitrobenzene,98%
- CBNumber:
- CB3359521
- Molecular Formula:
- C6H2Cl3NO2
- Molecular Weight:
- 226.44
- MDL Number:
- MFCD00061096
- MOL File:
- 20098-48-0.mol
| Product description | Number | Pack Size | Price |
| 1,2,3-Trichloro-5-nitrobenzene 96% | 411973 | 5g | $51 |
| 3,4,5-Trichloronitrobenzene >96.0%(GC) | T1580 | 5g | $29 |
| 3,4,5-Trichloronitrobenzene >96.0%(GC) | T1580 | 25g | $93 |
| 3,4,5-Trichloronitrobenzene | T774270 | 50g | $215 |
| 3,4,5-Trichloronitrobenzene | 62283 | 25g | $610 |
| More product size | |||
| Melting point | 68-71 °C (lit.) |
|---|---|
| Boiling point | 288°C (rough estimate) |
| Density | 1.8070 |
| refractive index | 1.6300 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| color | Pale Orange |
| Water Solubility | <0.1 g/100 mL at 15 ºC |
| BRN | 2505480 |
| InChI | InChI=1S/C6H2Cl3NO2/c7-4-1-3(10(11)12)2-5(8)6(4)9/h1-2H |
| InChIKey | HHLCSFGOTLUREE-UHFFFAOYSA-N |
| SMILES | C1(Cl)=CC([N+]([O-])=O)=CC(Cl)=C1Cl |
| CAS DataBase Reference | 20098-48-0(CAS DataBase Reference) |
| FDA UNII | AH0CU8672K |
| NIST Chemistry Reference | Benzene, 1,2,3-trichloro-5-nitro-(20098-48-0) |
| EPA Substance Registry System | Benzene, 1,2,3-trichloro-5-nitro- (20098-48-0) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 36/37/39-36/37 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29049090 | |||||||||
| NFPA 704 |
|
3,4,5-Trichloronitrobenzene price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 411973 | 1,2,3-Trichloro-5-nitrobenzene 96% | 20098-48-0 | 5g | $51 | 2023-06-20 | Buy |
| TCI Chemical | T1580 | 3,4,5-Trichloronitrobenzene >96.0%(GC) | 20098-48-0 | 5g | $29 | 2025-07-31 | Buy |
| TCI Chemical | T1580 | 3,4,5-Trichloronitrobenzene >96.0%(GC) | 20098-48-0 | 25g | $93 | 2025-07-31 | Buy |
| TRC | T774270 | 3,4,5-Trichloronitrobenzene | 20098-48-0 | 50g | $215 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 62283 | 3,4,5-Trichloronitrobenzene | 20098-48-0 | 25g | $610 | 2021-12-16 | Buy |
3,4,5-Trichloronitrobenzene Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
3,4,5-Trichloronitrobenzene a reagent, used in the synthesis of INT131, a PPARγ molecule that regulates insulin sensitivity. Also is used in the synthesis of thyroid hormone receptor β selective ligands that are used in hormone treatments.
General Description
Pale-yellow crystals or yellow crystalline solid.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
This type of compound is incompatible with strong bases and strong oxidizing agents. .
Fire Hazard
Flash point data for 3,4,5-Trichloronitrobenzene are not available; however, 3,4,5-Trichloronitrobenzene is probably combustible.
Synthesis
99-30-9
20098-48-0
General procedure for the synthesis of 1,2,3-trichloro-5-nitrobenzene from 2,6-dichloro-4-nitroaniline: 96 g of 98% concentrated sulphuric acid was added to the reaction flask at 20 °C, 7.2 g of sodium nitrite was added slowly with stirring, and then the temperature was raised to 70 °C. After the sodium nitrite was completely dissolved, the solution was cooled to 50°C. 20g of 2,6-dichloro-4-nitroaniline was added at once and the reaction was maintained at this temperature for 1 hour. After the reaction was completed, the mixture was cooled to 5 °C and 27.3 g of glacial acetic acid was slowly added dropwise. After the dropwise addition was completed, stirring was continued for 1 hour to obtain a 2,6-dichloro-4-nitroaniline diazonium salt solution. In another reaction flask, 18 g of cuprous chloride and 7.14 g of concentrated hydrochloric acid were added. The above diazonium salt solution was slowly added dropwise to this reaction flask under rapid stirring, keeping the temperature below 15 °C. After completion of the dropwise addition, the reaction was maintained for 1 hour, followed by raising the temperature to 70°C to continue the reaction for 1 hour. At the end of the reaction, the mixture was cooled to room temperature, poured into a 2L reaction flask, and 60 g of water was added under stirring. 0.5 h later, filtration was carried out to obtain 1,2,3-trichloro-5-nitrobenzene as a yellow solid with a dry weight of 21.5 g. The yield was 98.5%, and the purity was 98.3% by HPLC.
References
[1] Patent: CN104447597, 2018, B. Location in patent: Paragraph 0020; 0023; 0045-0047
[2] Patent: CN107746390, 2018, A. Location in patent: Paragraph 0021; 0022; 0023
[3] Journal of Medicinal Chemistry, 1980, vol. 23, # 10, p. 1083 - 1087
[4] Journal of the Chemical Society, 1926, p. 3044
[5] Patent: CN104098521, 2016, B. Location in patent: Paragraph 0038; 0039; 0040; 0041
3,4,5-Trichloronitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 427 | 58 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
| Aston Chemical | 13000000000 | sales@astonchem.com | United States | 1634 | 58 |
View Lastest Price from 3,4,5-Trichloronitrobenzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-10-08 | 1,2,3-Trichloro-5-nitrobenzene
20098-48-0
|
US $30.00 / L | 1L | 99% | 20T | Firsky International Trade (Wuhan) Co., Ltd | |
 |
2023-07-19 | 1,2,3-Trichloro-5-nitrobenzene
20098-48-0
|
US $30.00 / KG | 1KG | 99% | 20 Tons | Wuhan wingroup Pharmaceutical Co., Ltd | |
 |
2021-07-13 | 3,4,5-Trichloronitrobenzene
20098-48-0
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 1,2,3-Trichloro-5-nitrobenzene
20098-48-0
- US $30.00 / L
- 99%
- Firsky International Trade (Wuhan) Co., Ltd
-
- 1,2,3-Trichloro-5-nitrobenzene
20098-48-0
- US $30.00 / KG
- 99%
- Wuhan wingroup Pharmaceutical Co., Ltd
-
- 3,4,5-Trichloronitrobenzene
20098-48-0
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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