ChemicalBook >> CAS DataBase List >>Caulophylline
Caulophylline
- CAS No.
- 486-86-2
- Chemical Name:
- Caulophylline
- Synonyms
- (1r)-l;Caulophyllin;Caulophylline;Methylcytisine;N-METHYLCYTISINE;12-Methylcytisine;12-methyl-cytisin;Cytisine, 12-methyl-;METHYLCYTISINE, N-(P);Caulophylline USP/EP/BP
- CBNumber:
- CB3366194
- Molecular Formula:
- C12H16N2O
- Molecular Weight:
- 204.27
- MDL Number:
- MFCD00211091
- MOL File:
- 486-86-2.mol
- MSDS File:
- SDS
Last updated:2023-09-04 16:42:00
| Melting point | 137-139oC |
|---|---|
| alpha | 30D -224° (c = 1.05 in water) |
| Boiling point | 342.77°C (rough estimate) |
| Density | 1.0565 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | -20°C Freezer, Under Inert Atmosphere |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | powder |
| pka | 9.61±0.20(Predicted) |
| color | White to Off-White |
| EWG's Food Scores | 1 |
| FDA UNII | TT0MW69NCI |
| NIST Chemistry Reference | Caulophylline(486-86-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332 | |||||||||
| Precautionary statements | P261-P271-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HA4400000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 21 i.v.; 51 i.p. (Barlow, McLeod) | |||||||||
| NFPA 704 |
|
Caulophylline price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00353 | N-Methylcytisine ≥98% (HPLC) | 486-86-2 | 5mg | $197 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL83219 | N-Methylcytisine phyproof? Reference Substance | 486-86-2 | 10mg | $574 | 2024-03-01 | Buy |
| Sigma-Aldrich | CDS010442 | N-Methylcytisine AldrichCPR | 486-86-2 | 25mg | $308 | 2023-06-20 | Buy |
| Usbiological | M3398-60 | N-Methylcytisine | 486-86-2 | 25mg | $460 | 2021-12-16 | Buy |
| TRC | M294680 | N-Methylcytisine | 486-86-2 | 100mg | $460 | 2021-12-16 | Buy |
Caulophylline Chemical Properties,Uses,Production
Description
This base was first prepared synthetically by Partheil and subsequently discovered in the roots of Caulophyllurn thalictroides L. It is widespread among the Papilionaceae, being found in Baptisia australis, Genista tinctoria, Sophora microphylla, S. tetraptera, Thermopsis lanceolata and T. rhombifolia (Watt.) Richards. It is laevorotatory with [α]20D - 221 ° (H20) and furnishes the following crystalline salts and derivatives: hydrochloride, m.p. 2S0-SoC (dec.); hydriodide, m.p. 246-7°C (dec.); perchlorate, m.p. 2S4°C (dec.); aurichloride, m.p. 206°C (dec.); picrate, m.p. 230°C; picrolonate, m.p. 224-SoC (dec.) and the methiodide which occurs in two modifications, m.p. 248°C and 267-276°C.
Chemical Properties
Colourless Needles
Uses
N-Methylcytisine (cas# 486-86-2) is a compound useful in organic synthesis.
General Description
N-Methylcytisine is a nicotinic alkaloid found in Caulophyllum thalictroides, also known as blue cohosh.
Hazard
Extremely toxic; cardiotoxic; poisonous.
Biochem/physiol Actions
N-Methylcytisine is toxic and binds selectively to nicotinic acetylcholine receptors in the CNS.
References
Partheil., Arch. Pharm., 230,448 (1892)
Power, Salway., J. Chem. Soc., 103, 194 (1913)
Caulophylline Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 188)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
View Lastest Price from Caulophylline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | N-Methylcytisine
486-86-2
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2019-07-06 | Caulophylline
486-86-2
|
US $1.00 / KG | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- N-Methylcytisine
486-86-2
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Caulophylline
486-86-2
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
486-86-2(Caulophylline)Related Search:
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2'H-Androst-2-eno[3,2-c]pyrazol-5'(1'H)-one, 17-hydroxy-17-(methyl-d3)-, (5α,17β)- (9CI)
L-N-METHYLEPHEDRINE HYDROCHLORIDE
Caulophylline hydriodide
1of4
N-METHYLCYTISINE
(1r)-l
1,5-methano-8h-pyrido(1,2a)(1,5)diazocin-8-one,1,2,3,4,5,6-hexahydro-3-methy
1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R)-
1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R-cis)-
12-methyl-cytisin
12-Methylcytisine
Caulophyllin
Caulophylline
Cytisine, 12-methyl-
(1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
(1R,5S)-1,2,3,4,5,6-Hexahydro-3-methyl-1,5-methano-8H-pyrido[1,2-a][1,5]diazocin-8-one
(1R,5S)-3-Methyl-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one
[1R,(-)]-3-Methyl-1,2,3,4,5,6-hexahydro-1α,5α-methano-8H-pyrido[1,2-a][1,5]diazocine-8-one
METHYLCYTISINE, N-(P)
N-Methylcytisine AldrichCPR
Methylcytisine
N-Methylcytisine hydrobromide
N-Methylcytisine, 98%, from Sophora flavescens Aiton
1,5-Methano-8H-pyrido[1,2-a][1,5]diazocin-8-one, 1,2,3,4,5,6-hexahydro-3-methyl-, (1R,5S)-
Caulophylline USP/EP/BP
(1R)-1,2,3,4,5,6-hexahydro-1,5-methano-8H-pyrido[1,2-a][1,5]...
(1R,5S)-3-Methyl-3,4,5,6-tetrahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-8(2H)-one
486-86-2
chemical reagent
pharmaceutical intermediate
phytochemical
reference standards from Chinese medicinal herbs (TCM).
Miscellaneous Reagents
standardized herbal extract