ChemicalBook >> CAS DataBase List >>2-Diethylaminoethylchloride hydrochloride

2-Diethylaminoethylchloride hydrochloride

CAS No.
869-24-9
Chemical Name:
2-Diethylaminoethylchloride hydrochloride
Synonyms
DEC;2-Chlorotriethylamine hydrochloride;DEAC HCL;CCMO-39-002;oro-N,N-diethyL;CED 50% Solution;DEAC 65% Solution;TRISMETHOXYBENZENE;3,5-DIMETHOXYANISOLE;2-Diethylaminoethylc
CBNumber:
CB3371006
Molecular Formula:
C6H15Cl2N
Molecular Weight:
172.1
MDL Number:
MFCD00012519
MOL File:
869-24-9.mol
MSDS File:
SDS
Last updated:2023-05-15 10:43:56

2-Diethylaminoethylchloride hydrochloride Properties

Melting point 50-53 °C(lit.)
Boiling point 255 °C(lit.)
Density 1.1919 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.6000 (estimate)
Flash point 186 °F
storage temp. Poison room
solubility methanol: 0.1 g/mL, clear, colorless
form Crystalline Powder
color White to slightly beige
PH 5 (100g/l, H2O, 20℃)
Water Solubility 2000 g/L (20 ºC)
Sensitive Moisture Sensitive
BRN 3591991
Stability Hygroscopic, Moisture Sensitive
InChIKey RAGSWDIQBBZLLL-UHFFFAOYSA-N
Indirect Additives used in Food Contact Substances BETA-DIETHYLAMINOETHYL CHLORIDE
CAS DataBase Reference 869-24-9(CAS DataBase Reference)
FDA UNII YCY6EQT3WA
EPA Substance Registry System Diethyl-(2-chloroethyl)amine hydrochloride (869-24-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS08
Signal word  Danger
Hazard statements  H300-H314-H341-H412
Precautionary statements  P201-P260-P280-P301+P310+P330-P303+P361+P353-P305+P351+P338
Hazard Codes  Xn,T,Xi,T+
Risk Statements  22-36/37/38-26-24/25-23/24/25
Safety Statements  26-36-45-36/37/39-28A
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  DC2810000
Hazard Note  Irritant/Very Toxic
TSCA  Yes
HazardClass  6.1
PackingGroup  II
HS Code  29211980
NFPA 704
1
4 1

2-Diethylaminoethylchloride hydrochloride Chemical Properties,Uses,Production

Chemical Properties

2-Diethylaminoethylchloride hydrochloride is colourless to beige crystals

Uses

2-Chloro-N,N-diethylethylamine hydrochloride (65% in water) (DEC 65) is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet

Uses

2-Chloro-N,N-diethylethylamine hydrochloride can be used as an alkylating reagent for the synthesis of:

  • Substituted oxindole derivatives to be used as growth hormone secretagogs.
  • 1-Substituted-5,6-dinitrobenzimidazoles with antimicrobial and antiprotozoal activities.
  • Thiophene containing triarylmethane (TRAM) derivatives to be used as antitubercular agents.
  • Tris(2-(diethylamino)ethyl)amine to be used as a catalyst in combination with CuBr (Et6TREN/CuBr) for atom transfer radical polymerization of n-butyl acrylate.

It can also be used for the derivatization of chitosan to incorporate aminofunctionality onto it at C-6 position.

Uses

2-Diethylaminoethylchloride hydrochloride is used as intermediate for the syntheses of pharmaceuticals (e.g. amiodarone, butetamate citrate, flurazepam and naftidrofuryl). Product Data Sheet

Purification Methods

Crystallise the salt from absolute MeOH (to remove highly coloured impurities). [Beilstein 4 III 240.]

100-37-8
869-24-9
Synthesis of 2-Diethylaminoethylchloride hydrochloride from Diethylaminoethanol

2-Diethylaminoethylchloride hydrochloride Preparation Products And Raw materials

3,5-DIMETHOXYANISOLE (2-chloroethyl)diethylaminemonohydrochloride 1-chloro-2-(diethylamine)ethanehydrochloride 2-chloroethyl-n,n-diethylaminehydrochloride TRISMETHOXYBENZENE 2-chloro-n,n-diethyl-ethanaminhydrochloride 2-Chlorotriethylaminehydrochl 2-chloro-triethylaminhydrochloride B-(DIETHYLAMINO)ETHYLCHLORIDE HYDROCHLORIDE Ethanamine, 2-chloro-N,N-diethyl-, hydrochloride beta-chloroethyldiethylaminehydrochloride bis(ethyl)-2-chloroethylaminehydrochloride diethyl-beta-chloroethylaminehydrochloride 2-DIETHYLAMINOETHYL CHLORIDE HYDROCHLORIDE (DEAC HCL) DEAC HCL 2-(Diethylamino)ethyl chloride hydrochloride, 98+% N,N-Diethyl-2-chloroethanamine hydrochloride 2-DIETHYLAMINOETHYL CHLORIDE HYDROCHLORIDE extrapure N,N-Diethyl-β-chloroethylamine hydrochloride 2-(Diethylamino)ethyl chloride hydrochloride, 2-Chlorotriethylamine hydrochloride Diethylaminoethylchloride HCI 2-(DITHEYLAMINO)-ETHYL CHLORIDE HCL N-(2-CHLOROETHYL)-N,N-DIETHYLAMINE HYDROCHLORIDE 2-Chloro-N,N-diethylethaneamine hydrochloride 2-Diethylaminoethylchloride hydrochloride n-(2-chloroethyl)diethylammonium chloride 2-Chloro-N,N-diethylethylamine hydrochloride 98% 2-Chloro-N,N-diethylethylamine hydrochloride (65% in water) 2-Chloroethyldiethylamine·hydrochloric acid 2-Diethylaminoethylchloride hydrochlo Hydrochloride 2-(Diethylamino)ethyl chloride hydrochloride N,N-Diethylaminoethylchloride 2-Diethylaminoethylc 2-(Diethylamino)ethyl chloride hydrochloride, 1-Chloro-2-(diethylamino)ethane hydrochloride n,n-diethyl-2-chloroethylaminehydrochloride n,n-diethyl-beta-chloroethylaminehydrochloride n-2-chloroethyl-n,n-diethylammoniumhydrochloride 2-chloroethyldiethylammonium chloride 2-Diethylaminoethyl chloride HCL (DEAC, HCl) N-(2-Chloroethyl)diethylamine hydrochloride~N-(2-Chloroethyl)diethylammonium chloride CED 50% Solution DEAC 65% Solution N-(2-Chloroethyl)diethylamineHCl 2-DIETHYL AMINE ETHYL CHLORIDE HYDROCHLORIDE 1-CHLORO-2-DIETHYLAMINOETHANE HYDROCHLORIDE 2-Diethylaminoethylchloride hydrochloride, 99.50% 2-DiethylaMinoethylchloride hydrochloride, 99.5% 2-DiethylaMinoethylchloride hydrochloride, 99.5% 250GR 1-DiethylaMino-2-chloroethane Hydrochloride 2-(DiethylaMino)-1-chloroethane Hydrochloride Diethyl(2-chloroethyl)aMine Hydrochloride 2-Chloro-N,N-diethylethylamine Hydrochloride N-(2-Chloroethyl)diethylamine Hydrochloride 2-Chlorotriethylamine Hydrochloride N-(2-CHLOROETHYL)-N,N-DIETHYLAMMONIUM CH Amiodarone Related Compound H (20 mg) (2-chloro-N,N-diethylethanamine hydrochloride) AMiodarone Related CoMpound H EthanaMine,2-chloro-N,N-diethyl-, hydrochloride (1:1) N-(2-Chloroethyl)-N,N-diethylammonium chloride for synthesis 2-chloro-N,N-diethylethanamine:hydron:chloride