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D-AP5

CAS No.
79055-68-8
Chemical Name:
D-AP5
Synonyms
EIF4G2;D-AP5;IF4G2;D-APV;(R)-AP-5;Emasol L10;Emasol L 10;Emasol L-10;5-Phosphono-D-norvaline;D-Norvaline, 5-phosphono-
CBNumber:
CB3371309
Molecular Formula:
C5H12NO5P
Molecular Weight:
197.13
MDL Number:
MFCD00078839
MOL File:
79055-68-8.mol
Last updated:2023-06-30 15:45:59

D-AP5 Properties

Melting point approximate 233℃
Boiling point 482.1±55.0 °C(Predicted)
Density 1.529±0.06 g/cm3(Predicted)
RTECS RD2513000
storage temp. Store at RT
solubility Soluble to 100 mM in sterile
form White solid
pka 2.46±0.10(Predicted)
color White
Water Solubility Soluble in water (100mM)
Sensitive Light Sensitive
FDA UNII CD39X2NL7F

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
NFPA 704
0
2 0

D-AP5 price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A8054 D(?)-2-Amino-5-phosphonopentanoic acid NMDA receptor antagonist 79055-68-8 1mg $91.3 2024-03-01 Buy
Sigma-Aldrich 165304 D-(–)-2-Amino-5-phosphonopentanoic Acid 79055-68-8 5mg $166 2024-03-01 Buy
Alfa Aesar J64887 (R)-(-)-2-Amino-5-phosphonopentanoic acid, 99% 79055-68-8 10mg $325 2024-03-01 Buy
Cayman Chemical 14539 D-AP5 ≥95% 79055-68-8 5mg $57 2024-03-01 Buy
Cayman Chemical 14539 D-AP5 ≥95% 79055-68-8 10mg $100 2024-03-01 Buy
Product number Packaging Price Buy
A8054 1mg $91.3 Buy
165304 5mg $166 Buy
J64887 10mg $325 Buy
14539 5mg $57 Buy
14539 10mg $100 Buy

D-AP5 Chemical Properties,Uses,Production

Description

D-AP5 is a selective N-methyl-D-aspartate (NMDA) receptor antagonist (Kd = 1.4 μM) that competitively inhibits the glutamate binding site of NMDA receptors. Whereas D-AP5 is the active (−)-stereoisomer, its (+)-isomer (L-AP5) demonstrates considerably less potent NMDA receptor antagonist activity. AP5 has been widely used to study the activity of NMDA receptors particularly in regard to researching synaptic plasticity, learning, and memory.

Chemical Properties

white fine crystalline powder

Uses

A competitive NMDA antagonist

General Description

Active enantiomer of DL-2-amino-5-phosphonopentanoic acid (AP5) that is a commonly used competitive NMDA receptor antagonist.

Biological Activity

Widely used competitive NMDA antagonist. More active form of AP5. Also agonist at quisqualate-sensitized AP6 site where it is less potent than the L-isomer (L-(+)-2-Amino-5-phosphonopentanoic acid ). Also available as part of the Mixed NMDA Receptor Tocriset™ .

Biochem/physiol Actions

Product does not compete with ATP.

storage

Room temperature

D-AP5 Preparation Products And Raw materials

Raw materials

Preparation Products

D-AP5 Suppliers

Global( 128)Suppliers
Supplier Tel Email Country ProdList Advantage
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196 sale04@alfachem.cn China 12321 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 24738 58
Nantong HI-FUTURE Biology Co., Ltd.
+undefined18051384581 sales@chemhifuture.com China 3136 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
027-88013699 17354350817 Ryan@jiutian-bio.com China 7433 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Ascent Scientific 4401179829988 customerservice@ascentscientific.co.uk United Kingdom 279 60
Syntechem Co.,Ltd info@syntechem.com China 12990 57
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4647 58
D-AP5 D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID D-2-AMINO-5-PHOSPHONOPENTANOIC ACID D-(-)-2-AMINO-5-PHOSPHONOVALERIC ACID D(-)-2-Amino-5-phosphonovaleric acid hydrate D-(-)-2-AMINO-5-PHOSPHONOPENTANOIC ACID (D-AP5) D(-)-AP-5, D(-)-APV, D-2-Amino-5-phosphonovaleric acid (R)-2-aMino-5-phosphonopentanoic acid (2R)-2-aMMonio-5-phosphonatopentanoate Anti-EIF4G2, N-Terminal antibody produced in rabbit Death associated protein 5 Eukaryotic translation initiation factor 4 γ 2 IF4G2 D(-)-2-Amino-5-phosphonovaleric acid (D-AP5) (2R)-2-Amino-5-phosphonovaleric acid (R)-2-Amino-5-phosphonovaleric acid (R)-5-Phosphono-2-aminovaleric acid (R)-AP-5 D-APV D(-)-2-Amino-5-phosphonovaleric acid hydrate,96%, (>98% ee) D(-)-2-AMINO-5-PHOSPHONOPENTANOIC AC D-(–)-2-Amino-5-phosphonopentanoic Acid - CAS 79055-68-8 - Calbiochem 5-Phosphono-D-norvaline D(-)-2-AMINO-5-PHOSPHONOVALERIC ACID (D-AP5);5-PHOSPHONO-D-NORVALINE D-Norvaline, 5-phosphono- Emasol L 10 Emasol L10 Emasol L-10 EIF4G2 79055-68-8 C5H12NO5P Glutamate Glutamate receptor