Cucurbitacin E
- CAS No.
- 18444-66-1
- Chemical Name:
- Cucurbitacin E
- Synonyms
- 25-acetate;A-ELATERIN;Cucurbit E;α-Elaterine;Cucurbitine E;CUCURBITACIN E;ALPHA-ELATERIN;cucurbitacine-e;alpha-elaterine;CUCURBITACIN E(SH)
- CBNumber:
- CB3372306
- Molecular Formula:
- C32H44O8
- Molecular Weight:
- 556.69
- MDL Number:
- MFCD00135936
- MOL File:
- 18444-66-1.mol
- MSDS File:
- SDS
| Melting point | 228-234°C |
|---|---|
| alpha | D -59° (c = 0.7 in chloroform) |
| Boiling point | 545.56°C (rough estimate) |
| Density | 1.1059 (rough estimate) |
| refractive index | 1.4900 (estimate) |
| storage temp. | -20°C |
| solubility | DMSO: soluble15mg/mL, clear |
| form | powder |
| pka | 8.51±0.70(Predicted) |
| color | white to beige |
| optical activity | [α]/D -60 to -75°, c = 0.7 (CDCl3) |
| InChIKey | NDYMQXYDSVBNLL-MUYMLXPFSA-N |
| LogP | 3.150 (est) |
| FDA UNII | V8A45XYI21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 25-22 | |||||||||
| Safety Statements | 1-22-45-24/25 | |||||||||
| RIDADR | 3172 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RC6305500 | |||||||||
| HS Code | 29153900 | |||||||||
| Toxicity | LD50 orally in mice: 340 mg/kg (Albert) | |||||||||
| NFPA 704 |
|
Cucurbitacin E price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0577 | Cucurbitacin E ≥95% (HPLC) | 18444-66-1 | 5mg | $206 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0577 | Cucurbitacin E ≥95% (HPLC) | 18444-66-1 | 25mg | $955 | 2023-01-07 | Buy |
| Cayman Chemical | 14821 | Cucurbitacin E ≥98% | 18444-66-1 | 1mg | $41 | 2024-03-01 | Buy |
| Cayman Chemical | 14821 | Cucurbitacin E ≥98% | 18444-66-1 | 5mg | $162 | 2024-03-01 | Buy |
| Cayman Chemical | 14821 | Cucurbitacin E ≥98% | 18444-66-1 | 10mg | $302 | 2024-03-01 | Buy |
Cucurbitacin E Chemical Properties,Uses,Production
Description
Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro. Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis. It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner. Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.
Chemical Properties
white to beige powder
Uses
Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.
Uses
Cucurbitacin E is a biochemical compound from the family of Cucurbitacins. Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Cucurbitacin E is known to possess broad spectrum of potential anti-inflammatory, antitumor andantioxidant effects.
Definition
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.
Biochem/physiol Actions
Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.
Cucurbitacin E Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253 | jancyzheng@gcgreenpure.com | China | 952 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | sales@pioneerbiotech.com | China | 3000 | 58 |
| NanJing Spring & Autumn Biological Engineering CO., LTD. | +8613815430202 | sale02@cqherb.com | CHINA | 376 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
View Lastest Price from Cucurbitacin E manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Cucurbitacin E
18444-66-1
|
US $0.00 / mg | 20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2022-02-14 | Cucurbitacin E 18444-66-1
18444-66-1
|
US $255.00 / mg | 20mg | ≥98% | 1000.00 kgs | NanJing Spring & Autumn Biological Engineering CO., LTD. | |
 |
2021-11-02 | Cucurbitacin E
18444-66-1
|
US $285.00 / mg | 20mg | 99% | 10kg | Baoji Guokang Healthchem co.,ltd |
-
- Cucurbitacin E
18444-66-1
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Cucurbitacin E 18444-66-1
18444-66-1
- US $255.00 / mg
- ≥98%
- NanJing Spring & Autumn Biological Engineering CO., LTD.
-
- Cucurbitacin E
18444-66-1
- US $285.00 / mg
- 99%
- Baoji Guokang Healthchem co.,ltd
18444-66-1(Cucurbitacin E)Related Search:
1of4