5-Bromonicotinic acid
- CAS No.
- 20826-04-4
- Chemical Name:
- 5-Bromonicotinic acid
- Synonyms
- 5-BROMOPYRIDINE-3-CARBOXYLIC ACID;Nicergoline impurity D CRS;5-BROMO-3-PYRIDINECARBOXYLIC ACID;DF97;AURORA KA-3027;CAS:20826-04-4;AKOS BBS-00007710;5 - broMine niacin;TIMTEC-BB SBB003524;RARECHEM AL BO 0841
- CBNumber:
- CB3375701
- Molecular Formula:
- C6H4BrNO2
- Molecular Weight:
- 202.01
- MDL Number:
- MFCD00009783
- MOL File:
- 20826-04-4.mol
- MSDS File:
- SDS
| Melting point | 178-180 °C(lit.) |
|---|---|
| Boiling point | 259.67°C (rough estimate) |
| Density | 1.7477 (rough estimate) |
| vapor pressure | 0.01Pa at 25℃ |
| refractive index | 1.6120 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.08±0.10(Predicted) |
| form | Powder |
| color | White to yellow-gray or light brown |
| BRN | 115854 |
| InChI | InChI=1S/C6H4BrNO2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,(H,9,10) |
| InChIKey | FQIUCPGDKPXSLL-UHFFFAOYSA-N |
| SMILES | C1=NC=C(Br)C=C1C(O)=O |
| LogP | 1.17-1.29 at 23.5℃ and pH6.4 |
| CAS DataBase Reference | 20826-04-4(CAS DataBase Reference) |
| FDA UNII | ZDB972TSH7 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P305+P351+P338-P261-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QT0868000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333999 | |||||||||
| NFPA 704 |
|
5-Bromonicotinic acid price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 228435 | 5-Bromopyridine-3-carboxylic acid 98% | 20826-04-4 | 10g | $40.68 | 2024-03-01 | Buy |
| Sigma-Aldrich | 228435 | 5-Bromopyridine-3-carboxylic acid 98% | 20826-04-4 | 50g | $59.6 | 2024-03-01 | Buy |
| TCI Chemical | B1818 | 5-Bromonicotinic Acid >99.0%(GC)(T) | 20826-04-4 | 25g | $59 | 2024-03-01 | Buy |
| Alfa Aesar | A13589 | 5-Bromonicotinic acid, 98% | 20826-04-4 | 25g | $72.7 | 2021-12-16 | Buy |
| Alfa Aesar | A13589 | 5-Bromonicotinic acid, 98% | 20826-04-4 | 5g | $26.1 | 2021-12-16 | Buy |
5-Bromonicotinic acid Chemical Properties,Uses,Production
Chemical Properties
Light yellow Cryst
Uses
5-Bromopyridine-3-carboxylic acid (5-bromonicotinic acid) was used in the synthesis of 3-guanidinomethyl-5-iodopyridine.
Reactions
5-Bromonicotinic acid could used as starting material to synthesize 3-guanidinomethyl-5-iodopyridine. It is also used to prepare four novel multifunctional coordination compounds with different lanthanide(III) ions (Dy, Tb, Yb, and Nd). These materials possess different structures and dimensionalities and show interesting magnetic and luminescence properties, as well as a complete absence of cytotoxicity both in cancer and non-cancer Caco-2 cells[1-2].
Synthesis Reference(s)
Journal of the American Chemical Society, 70, p. 2381, 1948 DOI: 10.1021/ja01187a020
Purification Methods
The acid is recrystallised from H2O and then from EtOH using charcoal. The amide has m 219-219.5o (from aqueous EtOH), and the methyl ester, prepared by addition of ethereal diazomethane, can be purified by sublimation in a vacuum and has m 98-99o. The acid chloride also can be sublimed in vacuo and has m 74-75o and gives the methyl ester in MeOH. [Graf J Prakt Chem 138 244 1933, Bachman & Micucci J Am Chem Soc 70 2381 1948, Garcia et al. J Am Chem Soc 82 4430 1960, Misic-Vokovic et al. J Chem Soc 34 1978, Beilstein 22/2 V 181.]
References
[1] Vaidyanathan G, et al. Iodopyridine-for-iodobenzene substitution for use with low molecular weight radiopharmaceuticals: application to m-iodobenzylguanidine. Bioconjugate Chemistry, 1998; 9: 758–764.
[2] Ruiz C, et al. Multifunctional coordination compounds based on lanthanide ions and 5-bromonicotinic acid: magnetic, luminescence and anti-cancer properties. CrystEngComm, 2019; 21: 3881-3890.
5-Bromonicotinic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | Lingzhiyue@aliyun.com | China | 3091 | 58 |
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9353 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
View Lastest Price from 5-Bromonicotinic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-03-28 | 5-Bromonicotinic acid
20826-04-4
|
US $0.00 / kg | 25kg | 98% | Inquiry | PNP Biotech Co. Ltd | |
 |
2023-05-12 | 5-Bromonicotinic acid
20826-04-4
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2023-01-31 | 5-Bromonicotinic acid
20826-04-4
|
US $0.00 / Kg/Drum | 1Kg/Drum | 99% | 5000KG | Hebei Mojin Biotechnology Co., Ltd |
-
- 5-Bromonicotinic acid
20826-04-4
- US $0.00 / kg
- 98%
- PNP Biotech Co. Ltd
-
- 5-Bromonicotinic acid
20826-04-4
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- 5-Bromonicotinic acid
20826-04-4
- US $0.00 / Kg/Drum
- 99%
- Hebei Mojin Biotechnology Co., Ltd
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