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4-Benzyloxybenzaldehyde

4-Benzyloxybenzaldehyde structure

CAS No.: 4397-53-9

Chemical Name:: 4-Benzyloxybenzaldehyde

Synonyms: NSC 28298;NSC 131669;AKOS AU36-M28;ASISCHEM R39515;AKOS BBS-00003143;TIMTEC-BB SBB000526;4-Benzyloxybenzaldeh;OTAVA-BB BB7018801949;LABOTEST-BB LT00233210;4-BENZYLOXYBENZALDEHYDE

CBNumber:: CB3376041

Molecular Formula:: C14H12O2

Molecular Weight:: 212.24

MDL Number:: MFCD00003387

MOL File:: 4397-53-9.mol

MSDS File:: SDS

Last updated:2026-01-13 11:17:25

Product description	Number	Pack Size	Price
4-(Benzyloxy)benzaldehyde 97%	123714	25g	$91
4-(Benzyloxy)benzaldehyde 97%	123714	100g	$100
4-Benzyloxybenzaldehyde	B1325	25g	$53
4-Benzyloxybenzaldehyde	B285876	250g	$435
4-Benzyloxybenzaldehyde	B285876	25g	$45
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4-Benzyloxybenzaldehyde Properties

Melting point	71-74 °C (lit.)
Boiling point	197-199 °C (11 mmHg)
Density	1.1035 (rough estimate)
refractive index	1.6000 (estimate)
Flash point	197-199°C/20mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Sparingly)
form	Crystalline Powder
color	Creamish to yellow
Water Solubility	insoluble
Sensitive	Air Sensitive
BRN	1242385
InChI	1S/C14H12O2/c15-10-12-6-8-14(9-7-12)16-11-13-4-2-1-3-5-13/h1-10H,11H2
InChIKey	ZVTWZSXLLMNMQC-UHFFFAOYSA-N
SMILES	[H]C(=O)c1ccc(OCc2ccccc2)cc1
LogP	3.360 (est)
CAS DataBase Reference	4397-53-9(CAS DataBase Reference)
NIST Chemistry Reference	Benzyl 4-formylphenyl ether(4397-53-9)
EPA Substance Registry System	Benzaldehyde, 4-(phenylmethoxy)- (4397-53-9)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P271-P280

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

24/25

WGK Germany

9-23

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29124900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

4-Benzyloxybenzaldehyde price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	123714	4-(Benzyloxy)benzaldehyde 97%	4397-53-9	25g	$91	2025-07-31	Buy
Sigma-Aldrich	123714	4-(Benzyloxy)benzaldehyde 97%	4397-53-9	100g	$100	2023-06-20	Buy
TCI Chemical	B1325	4-Benzyloxybenzaldehyde	4397-53-9	25g	$53	2025-07-31	Buy
TRC	B285876	4-Benzyloxybenzaldehyde	4397-53-9	250g	$435	2021-12-16	Buy
TRC	B285876	4-Benzyloxybenzaldehyde	4397-53-9	25g	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
123714	25g	$91	Buy
123714	100g	$100	Buy
B1325	25g	$53	Buy
B285876	250g	$435	Buy
B285876	25g	$45	Buy

4-Benzyloxybenzaldehyde Chemical Properties,Uses,Production

Chemical Properties

creamish to yellow crystalline powder

Uses

4-Benzyloxybenzaldehyde is used in the synthesis of (5-fluoro-(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanenitrile),an estrogen receptor β-selective ligand. It is a position isomer of the adenylyl cyclase activator 2-benzyloxybenzaldehyde.

Uses

4-Benzyloxybenzaldehyde is a position isomer of the adenylyl cyclase activator 2-Benzyloxybenzaldehyde. 4-Benzyloxybenzaldehyde also has much less potent anticancer activity against HL-60 cells that i ts isomeric counterpart.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 32, p. 192, 1989 DOI: 10.1021/jm00121a035

General Description

4-(Benzyloxy)benzaldehyde was used in the synthesis of (5-fluoro-(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanenitrile),an estrogen receptor β-selective ligand.

Synthesis

P-hydroxybenzaldehyde 5g (41mmol) and potassium carbonate 11.3g into a three-necked flask, add N, N-dimethylformamide (DMF) 25ml, stirring for 15min to form a suspension, dropwise addition of benzyl chloride 5.7g (45mmol), the reaction at room temperature of 6-8h, TLC tracking reaction to the end of the ice-water mixture was poured into a large number of solids precipitation, filtration, washed a number of times with water. Filtered, washed with water for several times, dried to obtain a white solid 4-benzyloxybenzaldehyde 8.13g (yield 94%).

4-Benzyloxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

METHYL 6-HYDROXY-1H-INDOLE-2-CARBOXYLATE GARDENIN B 4-BENZYLOXYPHENYLACETIC ACID N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Phenol, 3-[2-(4-hydroxyphenyl)ethyl]-5-methoxy-

3-[4-(BENZYLOXY)PHENYL]-2-PHENYLACRYLIC ACID Propanedinitrile, 2-[[4-(phenylmethoxy)phenyl]methylene]- (2E)-3-[4-(benzyloxy)phenyl]-1-(4-methylphenyl)prop-2-en-1-one (2E)-3-[4-(Benzyloxy)phenyl]-1-(2-chlorophenyl)prop-2-en-1-one 4,4'-(Propane-1,3-diyl)diphenol

2-methoxy-3-[4-[3-(4-phenoxyphenoxy)propoxy]phenyl]propanoic acid

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4-Benzyloxybenzaldehyde Suppliers

Global( 388)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13620	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21599	55
Chembon Pharmaceutical Co., Ltd.	+86-28-8425-2981		CHINA	722	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29834	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Chembon Pharmaceutical Co., Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 4-Benzyloxybenzaldehyde manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-05	4-Benzyloxybenzaldehyde 4397-53-9	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2026-01-05	4-Benzyloxybenzaldehyde 4397-53-9	US $0.00-0.00 / KG	10mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
2019-07-06	4-Benzyloxybenzaldehyde 4397-53-9	US $8.00 / kg	1kg	99%	10TON	Career Henan Chemical Co

4-Benzyloxybenzaldehyde
4397-53-9
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

4-Benzyloxybenzaldehyde
4397-53-9
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

4-Benzyloxybenzaldehyde
4397-53-9
US $8.00 / kg
99%
Career Henan Chemical Co

4-Benzyloxybenzaldehyde Spectrum

4-Benzyloxybenzaldehyde(4397-53-9)MS 4-Benzyloxybenzaldehyde(4397-53-9)¹HNMR 4-Benzyloxybenzaldehyde(4397-53-9)¹³CNMR 4-Benzyloxybenzaldehyde(4397-53-9)IR1 4-Benzyloxybenzaldehyde(4397-53-9)IR2 4-Benzyloxybenzaldehyde(4397-53-9)Raman

4397-53-9(4-Benzyloxybenzaldehyde)Related Search:

4-Methoxybenzylchloride 4-Hydroxybenzaldehyde 4-Dimethylaminobenzaldehyde p-Anisaldehyde 3-(Trifluoromethyl)benzaldehyde

Monobenzone 2-Nitrobenzaldehyde Benzaldehyde o-Anisaldehyde 3-(METHOXYMETHOXY)BENZALDEHYDE

5-(4-FLUOROPHENYL)VALERIC ACID ent-EzetiMibe EzetiMibe (3R,4R,3'S)-IsoMer (R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one (3R,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

(4S)-3-(2,2-dimethylpropanoyl)-4-phenyl-1,3-oxazolidin-2-one 4-BENZOYLBUTYRIC ACID 5-(2-FLUOROPHENYL)-5-OXOVALERIC ACID

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AKOS AU36-M28 AKOS BBS-00003143 4-(Phenylmethoxy)benzaldehyde Benzaldehyde, 4-(phenylmethoxy)- Benzaldehyde, p-(benzyloxy)- LABOTEST-BB LT00233210 ASISCHEM R39515 TIMTEC-BB SBB000526 P-(BENZYLOXY)BENZALDEHYDE P-BENZYLOXY BENZALDEYHDE PARA-BENZYLOXYBENZALDEHYDE OTAVA-BB BB7018801949 4-BENZYLOXYBENZALDEHYDE 4-Benzyloxybenzaldehyde99% 4-BENXYLOXYBENZALDEHYDE 4-Benzyloxybenzaldehyde, 97+% 4-Benzyloxybenzaldehyde 99% 4-Benzyloxybenzaldehyde,98% ρ-Benzyloxybenzaldehyde 4-Benzyloxybenzaldeh NSC 131669 NSC 28298 4-BENZYLOXYBENZALDEHYDE FOR SYNTHESIS 4-Benzyloxybenzaldehyde, 98% 25GR Ibuprofen Related Compound (4-Benzyloxybenzaldehyde) 4-(Benzyloxy)benzaldehyde Vetec(TM) reagent grade, 97% 4-BENZYLOXYBENZALDEHYDE 4397-53-9 4397-53-9 ALDEHYDE Benzaldehyde (Building Blocks for Liquid Crystals) Building Blocks for Liquid Crystals Aldehydes Organic Building Blocks C10 to C21 Carbonyl Compounds Building Blocks Aromatics Intermediates & Fine Chemicals Pharmaceuticals FINE Chemical & INTERMEDIATES Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde (Building Blocks for Liquid Crystals) Building Blocks for Liquid Crystals Functional Materials Aldehydes C10 to C21 Carbonyl Compounds