Fluocortolone
- CAS No.
- 152-97-6
- Chemical Name:
- Fluocortolone
- Synonyms
- flucortolone;FLUORCORTOLONE;SH-742;SH 742;Fluocortolon;FLUOCORTOLONE;Fluorocortolone;Fluocortolone USP/EP/BP;Fluocortolone Impurity 13;methylfluorodehydrocorticosterone
- CBNumber:
- CB3378252
- Molecular Formula:
- C22H29FO4
- Molecular Weight:
- 376.46
- MDL Number:
- MFCD00867463
- MOL File:
- 152-97-6.mol
- MSDS File:
- SDS
| Melting point | 113-116°C |
|---|---|
| alpha | D20 +100° (dioxane) |
| Boiling point | 537.4±50.0 °C(Predicted) |
| Density | 1.1001 (estimate) |
| vapor pressure | 0.001Pa at 25℃ |
| storage temp. | Refrigerator |
| solubility | Chloroform (Slightly), Dioxane (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 12.98±0.10(Predicted) |
| color | Pale Yellow to Yellow |
| Water Solubility | 204mg/L at 20℃ |
| LogP | 2.3 at 25℃ |
| FDA UNII | 65VXC1MH0J |
| ATC code | C05AA08,D07AC05,D07XC05,H02AB03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H360-H301-H372 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P270-P314-P501 | |||||||||
| NFPA 704 |
|
Fluocortolone price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | F500500 | Fluocortolone | 152-97-6 | 1mg | $205 | 2021-12-16 | Buy |
| TRC | F500500 | Fluocortolone | 152-97-6 | 5mg | $925 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0007194 | FLUOCORTOLONE 95.00% | 152-97-6 | 10MG | $2887.5 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 70263 | Fluocortolone | 152-97-6 | 1mg | $675 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0007194 | FLUOCORTOLONE 95.00% | 152-97-6 | 1MG | $866.25 | 2021-12-16 | Buy |
Fluocortolone Chemical Properties,Uses,Production
Chemical Properties
Pale Yellow Solid
Originator
Ultralan,Schering,W. Germany,1965
Uses
Fluocortolone is a glucocorticoid used in the treatment of several conditions, including hemorrhoids. Fluocortolone is similar to Fluocortin, but with one less keto group.
Definition
ChEBI: Fluocortolone is a 21-hydroxy steroid.
Manufacturing Process
(a) 16α-Methyl-6α-Fluoro-δ4-11β,21-Diol-3,20-Dione:16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate (MP 132°/134° to 138°C, UVε238=
15,000) is hydroxylated with Curvularia lunata in 11β-position using the
fermentation method whereby the 21-acetate group is simultaneously
saponified. The hitherto unknown starting material 16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate is obtained from 16α-methyl-δ5-
pregnene-3β,21-diol-20-one-21-acetate, MP 152° to 154°C, by the addition of
bromofluorine (from N-bromoacetamide and hydrogen fluoride) onto the 5-6
double bond, oxidation of the 3β-hydroxyl group with chromic acid,
introduction of the δ4-double bond by splitting of the hydrogen bromide and
acid isomerization of the 6β-fluoro substituent to the 16α-methyl-6α-fluoro-δ4-
pregnene-21-ol-3,20-dione-21-acetate. By chromatographic purification on
silica gel the 16α-methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is: MP
166°/167° to 171°C.
(b) 16α-Methyl-6α-Fluoro-δ4-Pregnene-11β,21-Diol-3,20-Dione-21-Acetate:By
reaction of the compound of (a) with acetic anhydride in pyridine at room
temperature, the acetate is obtained and recrystallized from ethyl acetate, MP
248°/249° to 251°C.
(c) 16α-Methyl-6α-Fluoro-δ1,4-Pregnadiene-11β,21-Diol-3,20-Dione:16α-
methyl-6α-fluoro-δ4-pregnene-11β,21-diol-3,20-dione is dehydrogenated with
Corynebacterium simplex. The extraction residue is subjected to
chromatography on silica gel and after recrystallization there is obtained from
methylene chloride-isopropyl ether 16α-methyl-6α-fluoro-δ1,4-pregnadiene-
11β,21-diol-3,20-dione, MP 180°/181° to 182°C.
Therapeutic Function
Glucocorticoid
Flammability and Explosibility
Not classified
Fluocortolone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 | sean.lv@synzest.com | China | 323 | 58 |
| Longyan Tianhua Biological Technology Co., Ltd | 0086 18039857276 18039857276 | CHINA | 2783 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| China National Standard Pharmaceutical Corporation Limited | +8615391658522 | overseasales@yongstandards.com | China | 11927 | 58 |
View Lastest Price from Fluocortolone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-11-16 | Fluocortolone
152-97-6
|
US $550.00 / KG | 1KG | 99 | 1000KG | Longyan Tianhua Biological Technology Co., Ltd | |
 |
2020-01-13 | Fluocortolone
152-97-6
|
US $1.00 / KG | 1KG | 98%-99.9% | 200kg | Career Henan Chemical Co |
-
- Fluocortolone
152-97-6
- US $550.00 / KG
- 99
- Longyan Tianhua Biological Technology Co., Ltd
-
- Fluocortolone
152-97-6
- US $1.00 / KG
- 98%-99.9%
- Career Henan Chemical Co