Alendronic acid
- CAS No.
- 66376-36-1
- Chemical Name:
- Alendronic acid
- Synonyms
- ALENDRONATE;Bisphosphonate;Alendronate Sodium Hydrate;ABDP;R3-RM2;Onclast;Aledronate;alendronicaci;ALENDRONIC ACID;Alendronic Acid >
- CBNumber:
- CB3380835
- Molecular Formula:
- C4H13NO7P2
- Molecular Weight:
- 249.1
- MDL Number:
- MFCD00868112
- MOL File:
- 66376-36-1.mol
| Melting point | 230-235°C |
|---|---|
| Boiling point | 616.7±65.0 °C(Predicted) |
| Density | 1.857±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| Water Solubility | Insoluble in water |
| solubility | Aqueous Base (Sparingly), Methanol (Slightly), Water (Very Slightly) |
| form | powder to crystal |
| pka | pK1 2.72 ±0.05; pK2 8.73 ±0.05; pK3 10.5 ±0.1; pK4 11.6 ±0.1 at 25°, (0.1M KCl) |
| color | White to Light yellow |
| Merck | 14,229 |
| Stability | Hygroscopic |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | bisphosphonate |
| FDA UNII | X1J18R4W8P |
| ATC code | M05BA04 |
| EPA Substance Registry System | Phosphonic acid, P,P'-(4-amino-1-hydroxybutylidene)bis- (66376-36-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501 | |||||||||
| RIDADR | 1759 | |||||||||
| RTECS | SZ6521833 | |||||||||
| HS Code | 2931.90.9051 | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| NFPA 704 |
|
Alendronic acid price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2120 | Alendronic Acid >98.0%(T) | 66376-36-1 | 5g | $67 | 2024-03-01 | Buy |
| TCI Chemical | A2120 | Alendronic Acid >98.0%(T) | 66376-36-1 | 25g | $199 | 2024-03-01 | Buy |
| Chem-Impex | 37567 | Alendronicacid,98%(Assaybytitration) 98%(Assaybytitration) | 66376-36-1 | 25G | $217.28 | 2021-12-16 | Buy |
| Matrix Scientific | 099914 | (4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid 95+% | 66376-36-1 | 10g | $68 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA38407 | Alendronic acid | 66376-36-1 | 250g | $312.5 | 2021-12-16 | Buy |
Alendronic acid Chemical Properties,Uses,Production
Originator
Adronat ,Neopharmed ,Italy
Uses
Alendronate acid is an inhibitor of FDPS.
Definition
ChEBI: A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Manufacturing Process
4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask
with condenser, stirrer and dropping funnel, placed on a thermostatized bath;
the air is then removed with a nitrogen stream which is continued during all
the reaction. The acid is melted by heating the bath to 95°C. When melting is
complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which
is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2
moles) is added dropwise causing the mixture to boil and evolution of gaseous
hydrochloric acid which is damped by means of a suitable trap. The addition
rate is adjusted so as to keep a constant reflux for about 60 minutes. When
the addition is nearly over, the mixture swells, slowly hardening. Stirring is
continued as long as possible, whereafter the mixture is heated for further 3
hours. Without cooling, but removing the bath, water (300 ml) is added, first
slowly and then quickly. Heating and stirring are started again. Decolorizing
charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered
on paper and the filtrate is refluxed for 6 hours. After cooling is slowly
poured in stirred methanol (1500 ml) causing thereby the separation of a
white solid which collected and dried (161 g; 64.6%). The structure of ABDT
is confirmed by IR spectrum, proton magnetic and nuclear magnetic
resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of
sodium hydroxide.
Therapeutic Function
Antiosteoporotic
Hazard
A reproductive hazard.
Clinical Use
Bisphosphonate:
Treatment and prophylaxis of osteoporosis
Drug interactions
Potentially hazardous interactions with other drugs
Calcium salts: reduced absorption of alendronate.
Metabolism
Alendronate transiently distributes to soft tissues but is then rapidly redistributed to bone or excreted in the urine. There is no evidence that alendronate is metabolised in animals or humans. Following a single intravenous dose of [14C]-alendronate, approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no radioactivity was recovered in the faeces.
Alendronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
View Lastest Price from Alendronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-29 | Alendronic acid USP/EP/BP
66376-36-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-04 | Alendronic acid
66376-36-1
|
US $0.00-0.00 / KG | 1KG | 99.0% | 600 Tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-09-02 | Alendronic acid
66376-36-1
|
US $7.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- Alendronic acid USP/EP/BP
66376-36-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Alendronic acid
66376-36-1
- US $0.00-0.00 / KG
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- Alendronic acid
66376-36-1
- US $7.00 / KG
- 99%
- Career Henan Chemical Co
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