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L-Valine

Amino acids Content Analysis Chemical property Uses
L-Valine
L-Valine structure
CAS No.
72-18-4
Chemical Name:
L-Valine
Synonyms
L-Val;L-VLA;Valin;VALINE;2,3-D2);H-VAL-OH;L-VALINE;L-Val-OH;NSC 76038;Valine (V)
CBNumber:
CB3381690
Molecular Formula:
C5H11NO2
Formula Weight:
117.15
MOL File:
72-18-4.mol

L-Valine Properties

Melting point:
295-300 °C (subl.)(lit.)
alpha 
28 º (c=8, 6N HCl)
Boiling point:
213.6±23.0 °C(Predicted)
Density 
1.23
refractive index 
28 ° (C=8, HCl)
storage temp. 
Store at RT.
solubility 
H2O: 25 mg/mL
pka
2.29(at 25℃)
form 
powder
color 
White
PH
5.5-6.5 (100g/l, H2O, 20℃)
optical activity
[α]20/D +27.0±0.5°, c = 5% in 5 M HCl
Water Solubility 
85 g/L (20 ºC)
λmax
λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.1
Merck 
14,9909
BRN 
1721136
InChIKey
KZSNJWFQEVHDMF-BYPYZUCNSA-N
FDA 21 CFR
172.320; 582.5925; 172.320; 310.545
CAS DataBase Reference
72-18-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
L-VALINE
EWG's Food Scores
1
FDA UNII
HG18B9YRS7
NIST Chemistry Reference
Valine(72-18-4)
EPA Substance Registry System
L-Valine (72-18-4)
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  40
Safety Statements  24/25-36-22
WGK Germany  3
RTECS  YV9361000
TSCA  Yes
HS Code  29224995
Toxicity LD50 intraperitoneal in rat: 5390mg/kg
NFPA 704
0
1 0

L-Valine price More Price(37)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 50848 L-Valine certified reference material, TraceCERT 72-18-4 100mg $101 2020-08-18 Buy
Sigma-Aldrich 1708503 L-Valine United States Pharmacopeia (USP) Reference Standard 72-18-4 200mg $429 2020-08-18 Buy
TCI Chemical V0014 L-Valine >98.0%(T) 72-18-4 25g $22 2020-06-24 Buy
TCI Chemical V0014 L-Valine >98.0%(T) 72-18-4 100g $62 2020-06-24 Buy
Alfa Aesar A12720 L-Valine, 99% 72-18-4 25g $28 2020-06-24 Buy

L-Valine Chemical Properties,Uses,Production

Amino acids

L-Valine is a kind of branched-chain amino acids (BCAA). Animal cannot synthesize it by itself. It must be obtained from the diet to meet their nutritional needs. Therefore L-valine belongs to the essential amino acids.
Amino acids are the basic structural unit of protein synthesis, and the predecessor of other amines that metabolism needs. They are indispensable materials in our life. At present, it is known that there are 20 to 30 amino acids. Some of them can be synthesized in the human body, which are known as non-essential amino acids. And some, called essential amino acids, cannot be synthesized in the human body that should be supplemented from the outside. Mammal cells need twelve essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. These amino acids are all laevoisomer, and some non-essential amino acids of dextroisomer may have inhibitory effect on cultured cells.
L-amino acids can easier to be absorbed than D-amino acids. And the absorption of D, L-methionine has no difference. There is competition between the body transport of amino acids. The transporting of an amino acid can be suppressed by the presence of another amino acid. For example, L-valine and L-methionine can inhibit the absorption of L-leucine. Excessive lysine in dietary can inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine. Because it can be transported through another route.

Content Analysis

About 200mg sample is accurately weighed, dissolved in 3ml formic acid and 50ml glacial acetic acid. Add 2 drops of crystal violet test solution (TS-74), then use 0.1mol/L perchloric acid to titrate the solution to green or blue disappear entirely. Each Ml0.1mol/L perchloric acid is equivalent to 11.72mg L-valine (C5H11NO2).

Chemical property

White crystal or crystalline powder, odorless, bitter taste. Soluble in water, solubility in water of 8.85% at 25℃. Almost insoluble in ethanol, ether, acetone. melting point(decomposition point) 315℃, isoelectric point 5.96, [α]25D+28.3 (C = 1-2g/ml, in 5mol/L HCl).

Uses

Description

Valine (abbreviated as Val or V) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classified as nonpolar. Human dietary sources are any proteinaceous foods such as meats, dairy products, soy products, beans and legumes.
Along with leucine and isoleucine, valine is a branched-chain amino acid. It is named after the plant valerian. In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine is hydrophobic, the hemoglobin is prone to abnormal aggregation.

Chemical Properties

White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.

Uses

L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grai ns, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.

Uses

valine is an amino acid used as a skin-conditioning and odor-masking agent. It is more commonly used in hair care preparations than in skin care.

Definition

ChEBI: The L-enantiomer of valine.

Biosynthesis

Valine is an essential amino acid, hence it must be ingested, usually as a component of proteins. It is synthesized in plants via several steps starting from pyruvic acid. The initial part of the pathway also leads to leucine. The intermediate α-ketoisovalerate undergoes reductive amination with glutamate. Enzymes involved in this biosynthesis include :
Acetolactate synthase
Acetohydroxy acid isomeroreductase
Dihydroxyacid dehydratase
Valine aminotransferase.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 23, p. 167, 1975
The Journal of Organic Chemistry, 38, p. 822, 1973
Tetrahedron Letters, 22, p. 2411, 1981 DOI: 10.1016/S0040-4039(01)82922-1

Safety Profile

Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Chemical Synthesis

Racemic valine can be synthesized by bromination of isovaleric acid followed by amination of the α-bromo derivative
HO2CCH2CH(CH3)2 + Br2 → HO2CCHBrCH(CH3)2 + HBr
HO2CCHBrCH(CH3)2 + 2 NH3 → HO2CCH(NH2)CH(CH3)2 + NH4Br
.

Purification Methods

Crystallise L-valine from water by addition of EtOH. It sublimes at 178-188o/0.03mm with 99.3% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Perrin J Chm Soc 3125 1958, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2368-23771961, Beilstein 4 IV 2659.]

Nomenclature

According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons.

L-Valine Preparation Products And Raw materials

Raw materials

Preparation Products


L-Valine Suppliers

Global( 625)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21869 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22623 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3014 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24935 60
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55

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View Lastest Price from L-Valine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-09-10 L-Valine
72-18-4
US $50.00 / KG 1KG 99%,HPLC 100kg Zhuozhou Wenxi import and Export Co., Ltd
2019-12-26 L-Valine
72-18-4
US $0.00 / mg 5mg ≥98%(HPLC) 10 g Shanghai Standard Technology Co., Ltd.
2019-07-23 L-Valine
72-18-4
US $1.00 / g 1g 99% 1000 Kilogram/Kilograms per Week Cangzhou Wanyou New Material Technology Co.,Ltd

L-Valine Spectrum


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