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Vecuronium bromide

Description References
Vecuronium bromide
Vecuronium bromide structure
CAS No.
50700-72-6
Chemical Name:
Vecuronium bromide
Synonyms
VBMC;nc-45;orgnc45;norcuron;Musculax;Muscurate;vecuronium;mide,diacetate;VECRONIUM BROMIDE;Vecuronim Bromide
CBNumber:
CB3382859
Molecular Formula:
C34H57BrN2O4
Formula Weight:
637.73138
MOL File:
50700-72-6.mol

Vecuronium bromide Properties

Melting point:
227-229°C
alpha 
+30.5~+35.0゜(D/20℃)(c=0.5,dil.HCl)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in acetonitrile and in anhydrous ethanol.
form 
neat
Merck 
14,9941
BRN 
4837308
InChIKey
VEPSYABRBFXYIB-PWXDFCLTSA-M
CAS DataBase Reference
50700-72-6(CAS DataBase Reference)
FDA UNII
7E4PHP5N1D
NCI Drug Dictionary
Norcuron
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-37/39
WGK Germany  3
RTECS  TN4875000
HS Code  2933399090
Toxicity LD50 in mice: 0.061 mg/kg i.v. (Buckett)

Vecuronium bromide price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 76904 Vecuronium bromide ≥97.0% (TLC) 50700-72-6 10mg $113 2021-03-22 Buy
Sigma-Aldrich 1711155 Vecuronium bromide United States Pharmacopeia (USP) Reference Standard 50700-72-6 50mg $366 2020-08-18 Buy
TCI Chemical V0120 Vecuronium Bromide Hydrate >98.0%(HPLC)(T) 50700-72-6 100mg $253 2021-03-22 Buy
Cayman Chemical 15603 Vecuronium (bromide) ≥98% 50700-72-6 50mg $96 2021-03-22 Buy
Cayman Chemical 15603 Vecuronium (bromide) ≥98% 50700-72-6 10mg $48 2021-03-22 Buy

Vecuronium bromide Chemical Properties,Uses,Production

Description

Vecuronium bromide (Brand name: Norcuron) is a drug which can be supplied to general anesthesia to keep skeletal muscle relaxation during the surgery or mechanical ventilation. It can also be used to help with endotracheal intubation. It has rapid onset (within 4 minutes) and has its effect last for 4 hour. Its mechanism of action is through competitively binding to the nicotinic cholinergic receptors, further antagonizing the opportunity for acetylcholine from binding to the nicotinic receptor at the postjunctional membrane of the myoneural junction. This process prevents the depolarization and the release of calcium ions, stopping muscle contraction and help muscle relaxation.

References

https://en.wikipedia.org/wiki/Vecuronium_bromide
https://www.drugbank.ca/drugs/DB01339  

Description

Vecuronium, 1-[(2β,3α,5α,16β,17β,)-3,17-bis(acetyloxy)-2-(1-piperidinyl) androstan-16-yl]-1-methylpiperidinium bromide (15.1.9), differs from panuronium only in the extent of alkylation. Only the piperidine substituent on C16 of the steroid skeleton is transformed into a quaternary salt.

Chemical Properties

White Solid

Uses

alcohol antagonist

Uses

An aminosteroid, competitive neuromuscular blocker agent.

Definition

ChEBI: The organic bromide salt of a 5alpha-androstane compound having 3alpha-acetoxy-, 17beta-acetoxy-, 2beta-piperidinino- and 16beta-N-methylpiperidinium su stituents.

brand name

Norcuron (Organon).

Biological Functions

Vecuronium bromide (Norcuron) is chemically identical to pancuronium except for a tertiary amine in place of a quaternary nitrogen. However, some of the drug will exist as the bisquaternary compound, depending on body pH. Vecuronium has a moderate onset of action (2.4 minutes) and a duration of effect of about 50 minutes. Like pancuronium, it does not block ganglia or vagal neuroeffector junctions, does not release histamine, and is eliminated by urinary excretion.

General Description

Vecuronium bromide, 1-(3 ,17 -dihydroxy-2 -piperidino-5 -androstan-16 -yl)-1-methylpiperidinium bromide diacetate (Norcuron), is themonoquaternary analog of pancuronium bromide. It belongsto the class of nondepolarizing neuromuscular blockingagents and produces effects similar to those of drugs in thisclass. It is unstable in the presence of acids and undergoesgradual hydrolysis of its ester functions in aqueous solution.Aqueous solutions have a pH of about 4.0.

Clinical Use

Vecuronium Bromide is usedmainly to produce skeletal muscle relaxation during surgeryand to assist in controlled respiration after general anesthesiahas been induced.

Veterinary Drugs and Treatments

Vecuronium is indicated as an adjunct to general anesthesia to produce muscle relaxation during surgical procedures or mechanical ventilation and to facilitate endotracheal intubation. It causes very minimal cardiac effects and generally does not cause the release of histamine.

Vecuronium bromide Preparation Products And Raw materials

Raw materials

Preparation Products


Vecuronium bromide Suppliers

Global( 323)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5361 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Shanghai Yingrui Biopharma Co.,Ltd
+86-21-33585366
+86-21-34979012 export01@shyrchem.com CHINA 1321 58

View Lastest Price from Vecuronium bromide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-08-26 Vecuronium Bromide
50700-72-6
US $10.00 / Kg/Drum 1KG 98% 10 ton Hebei Crovell Biotech Co Ltd
2021-07-13 Vecuronium bromide
50700-72-6
US $11000.00 / Kg/Bag 20g 99%-101% 100kg/month Hebei Yanxi Chemical Co., Ltd.
2021-07-13 Vecuronium bromide
50700-72-6
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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