(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
- CAS No.
- 588-36-3
- Chemical Name:
- (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
- Synonyms
- Methioprim;(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)ME...;4-AMINO-2-(METHYLTHIO)-5-PYRIMIDINEMETHANOL;4-Amino-2-(methylthio)-5-pyrimidinyl]methanol;5-Pyrimidinemethanol, 4-amino-2-(methylthio)-;4-AMINO-2-METHYLMERCAPTO-PYRIMIDINE-4-CARBINOL;(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL;4-AMINO-5-HYDROXYMETHYL-2-(METHYLTHIO)PYRIMIDINE;(4-AMINO-2-METHYLSULFANYL-PYRIMIDIN-5-YL)-METHANOL;(4-azanyl-2-methylsulfanyl-pyrimidin-5-yl)methanol
- CBNumber:
- CB3387753
- Molecular Formula:
- C6H9N3OS
- Molecular Weight:
- 171.22
- MDL Number:
- MFCD08236793
- MOL File:
- 588-36-3.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methioprim | M260520 | 25mg | $315 |
| Methioprim | M260520 | 100mg | $1110 |
| 4-AMINO-2-METHYLMERCAPTO-PYRIMIDINE-4-CARBINOL 95.00% | CHM1051884 | 5G | $1888.43 |
| [4-Amino-2-(methylsulfanyl)pyrimidin-5-yl]methanol 97.0% | 8H66-1-6F | 5G | $790 |
| (4-Amino-2-(methylthio)pyrimidin-5-yl)methanol 97% | 071115 | 5g | $1035 |
| More product size | |||
| Melting point | 126-127° |
|---|---|
| Boiling point | 408.6±30.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 13.08±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| FDA UNII | 6213O32QRM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| HS Code | 29335990 |
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M260520 | Methioprim | 588-36-3 | 25mg | $315 | 2021-12-16 | Buy |
| TRC | M260520 | Methioprim | 588-36-3 | 100mg | $1110 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM1051884 | 4-AMINO-2-METHYLMERCAPTO-PYRIMIDINE-4-CARBINOL 95.00% | 588-36-3 | 5G | $1888.43 | 2021-12-16 | Buy |
| SynQuest Laboratories | 8H66-1-6F | [4-Amino-2-(methylsulfanyl)pyrimidin-5-yl]methanol 97.0% | 588-36-3 | 5G | $790 | 2021-12-16 | Buy |
| Matrix Scientific | 071115 | (4-Amino-2-(methylthio)pyrimidin-5-yl)methanol 97% | 588-36-3 | 5g | $1035 | 2021-12-16 | Buy |
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL Chemical Properties,Uses,Production
Chemical Properties
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL is white cryst powder
Uses
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL is an intermediate used in the synthesis of Thiamine (T344185). Also, used for the preparation of pyridopyrimidines and naphthyridines as inhibitors of Akt kinase for the treatment of cancer.
Uses
Tumor antagonist in mice.
Synthesis
776-53-4
588-36-3
General procedure for the synthesis of 2-(methylthio)-4-aminopyrimidine-5-carboxylic acid from ethyl 2-(methylthio)-4-aminopyrimidine-5-carboxylate: ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate (72.3 g, 339 mmol) was dissolved in tetrahydrofuran (THF, 900 mL) and the solution was cooled to 0 °C. A solution of LiAlH4 (2 M in THF, 195 mL, 390 mmol) was added slowly and dropwise over 1 hour. The reaction mixture was kept stirred at 0 °C for 2 h, then allowed to warm slowly to room temperature and continued stirring overnight. Upon completion of the reaction, the mixture was again cooled to 0 °C and water (15 mL), 20% aqueous potassium hydroxide solution (15 mL) and water (30 mL) were carefully added in turn to quench the reaction. The resulting mixture was stirred for 1 hour. Subsequently, it was dried with anhydrous magnesium sulfate (MgSO4), filtered, and the filtrate was concentrated under reduced pressure and finally dried under vacuum to afford the target product 2-methylthio-4-aminopyrimidine-5-methanol (55.85 g, 96% yield). Mass spectrometry (MS) analysis showed m/z: 172.1 ([M + H]+).
References
[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2371 - 2387
[2] Patent: WO2013/134243, 2013, A1. Location in patent: Page/Page column 16
[3] Journal of Medicinal Chemistry, 2015, vol. 58, # 10, p. 4165 - 4179
[4] Patent: WO2014/151682, 2014, A1. Location in patent: Page/Page column 57; 58
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 3, p. 578 - 599
(4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| KARMEL TECHNOLOGY (HK) CO.,LIMITED | +8618795957998 | karmelhk@126.com | CHINA | 2886 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 20284 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9644 | 58 |
View Lastest Price from (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2021-12-14 | (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
588-36-3
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-08-09 | (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
588-36-3
|
US $8.80 / KG | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
588-36-3
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- (4-AMINO-2-(METHYLTHIO)PYRIMIDIN-5-YL)METHANOL
588-36-3
- US $8.80 / KG
- 97%-99%
- Career Henan Chemical Co
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