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5-Methoxy-2-methylaniline

5-Methoxy-2-methylaniline structure

CAS No.: 50868-72-9

Chemical Name:: 5-Methoxy-2-methylaniline

Synonyms: NSC 229308;Einecs 256-816-4;6-METHYL-M-ANISIDINE;5-methoxy-o-toluidine;5-Methoxy-2-methylani;LABOTEST-BB LTBB000645;3-Amino-4-methylanisole;5-Methoxy-2-Methylanilin;2-amino-4-methoxytoluene;3-Methoxy-6-methylaniline

CBNumber:: CB3401640

Molecular Formula:: C8H11NO

Molecular Weight:: 137.18

MDL Number:: MFCD00075057

MOL File:: 50868-72-9.mol

MSDS File:: SDS

Last updated:2025-09-25 19:11:34

Product description	Number	Pack Size	Price
5-Methoxy-2-methylaniline 97%	335436	1g	$44.8
5-Methoxy-2-methylaniline 97%	335436	5g	$196
5-Methoxy-2-methylaniline >98.0%(GC)(T)	M3009	1g	$47
5-Methoxy-2-methylaniline >98.0%(GC)(T)	M3009	5g	$186
5-Methoxy-2-methylaniline	M336795	5g	$65
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5-Methoxy-2-methylaniline Properties

Melting point	43-46 °C (lit.)
Boiling point	253°C(lit.)
Density	1.0630 (rough estimate)
refractive index	1.5647 (estimate)
Flash point	>230 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Sparingly), Methanol (Slightly)
form	Powder
pka	4.03±0.10(Predicted)
color	Off-white to pale grey to yellow
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C8H11NO/c1-6-3-4-7(10-2)5-8(6)9/h3-5H,9H2,1-2H3
InChIKey	RPJXLEZOFUNGNZ-UHFFFAOYSA-N
SMILES	C1(N)=CC(OC)=CC=C1C
FDA UNII	98CG6GH37M
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS06

Signal word

Warning

Hazard statements

H331-H302-H312-H315-H319-H332-H335

Precautionary statements

P261-P280-P305+P351+P338-P304+P340-P405-P501a

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

26-37/39

WGK Germany

HazardClass

6.1

HS Code

29222990

NFPA 704

	1
2		0

5-Methoxy-2-methylaniline price More Price(30)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	335436	5-Methoxy-2-methylaniline 97%	50868-72-9	1g	$44.8	2023-06-20	Buy
Sigma-Aldrich	335436	5-Methoxy-2-methylaniline 97%	50868-72-9	5g	$196	2023-06-20	Buy
TCI Chemical	M3009	5-Methoxy-2-methylaniline >98.0%(GC)(T)	50868-72-9	1g	$47	2024-03-01	Buy
TCI Chemical	M3009	5-Methoxy-2-methylaniline >98.0%(GC)(T)	50868-72-9	5g	$186	2024-03-01	Buy
TRC	M336795	5-Methoxy-2-methylaniline	50868-72-9	5g	$65	2021-12-16	Buy

Product number	Packaging	Price	Buy
335436	1g	$44.8	Buy
335436	5g	$196	Buy
M3009	1g	$47	Buy
M3009	5g	$186	Buy
M336795	5g	$65	Buy

5-Methoxy-2-methylaniline Chemical Properties,Uses,Production

Chemical Properties

White to gray to tan crystalline powder

Uses

5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide.

Uses

5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide.

Synthesis

17484-36-5

50868-72-9

Under nitrogen atmosphere, 4-methoxy-1-methyl-3-nitrobenzene (18.0 g, 108 mmol) was dissolved in 160 mL of 1,2-dimethoxyethane (DME), followed by the addition of 10% Pd/C catalyst (0.9 g). Hydrazine hydrate (16.17 g, 323 mmol) was slowly added dropwise to the above solution. The reaction mixture was heated to reflux and stirred continuously for 4 hours. After that, 3 mL of hydrazine hydrate was added additionally and stirring was continued under reflux conditions for 2 days. Upon completion of the reaction, the mixture was cooled to room temperature and filtered through a diatomaceous earth pad to remove the catalyst. The filtrate was concentrated under reduced pressure to remove the solvent to give the crude product 5-methoxy-2-methylaniline as a yellow oil. After further vacuum drying, the product solidified to a pale yellow solid in a yield of 14.8 g (100% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.94 (d, J = 7.53 Hz, 1H), 6.28 (d, J = 7.53 Hz, 1H), 6.26 (s, 1H), 3.78 (s, 3H), 3.5 (br, 1H), 2.10 (s, 3H), 1.6 (br, 1H).

References

[1] Patent: WO2009/117097, 2009, A1. Location in patent: Page/Page column 70-71
[2] Tetrahedron, 2018, vol. 74, # 12, p. 1294 - 1306
[3] Justus Liebigs Annalen der Chemie, 1882, vol. 215, p. 83
[4] Journal of the Chemical Society, 1929, p. 870
[5] Journal of the Chemical Society, 1925, vol. 127, p. 995

5-Methoxy-2-methylaniline Preparation Products And Raw materials

Raw materials

Acetonitrile Potassium carbonate Glycine Palladium Palladium on activated carbon 5% Pd

4-Methyl-3-nitrophenol Dimethyl sulfate 4-Methyl-3-nitroanisole 1,2-Dimethoxyethane Hydrazine hydrate

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Preparation Products

2-hydroxy-4-Methoxytoluene 3-FLUORO-4-METHYLANISOLE 5-Methoxy-8-methyl-quinoline

5-Methoxy-2-methylaniline Suppliers

Global( 160)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8770	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12218	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3965	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from 5-Methoxy-2-methylaniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-10	5-Methoxy-2-methylaniline 50868-72-9	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-09-25	5-Methoxy-2-methylaniline 50868-72-9	US $0.00 / KG	1KG	99%	50000KG/month	Sichuan Zhuoyu Yantang Technology Co., Ltd.
2024-04-29	2-amino-4-methoxytoluene 50868-72-9	US $5.00 / kg	1kg	99.92%	50000tons	Ouhuang Engineering Materials (Hubei) Co., Ltd

5-Methoxy-2-methylaniline
50868-72-9
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

5-Methoxy-2-methylaniline
50868-72-9
US $0.00 / KG
99%
Sichuan Zhuoyu Yantang Technology Co., Ltd.

2-amino-4-methoxytoluene
50868-72-9
US $5.00 / kg
99.92%
Ouhuang Engineering Materials (Hubei) Co., Ltd

5-Methoxy-2-methylaniline Spectrum

5-Methoxy-2-methylaniline(50868-72-9)¹HNMR 5-Methoxy-2-methylaniline(50868-72-9)IR

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3-AMino-4-Methylanisole[5-Methoxy-2-Methylaniline] LABOTEST-BB LTBB000645 5-Methoxy-2-Methylaniline, 97% 1GR 5-Methoxy-2-Methylaniline, 97% 5GR 6-METHYL-M-ANISIDINE 3-Amino-4-methylanisole 3-Methoxy-6-methylaniline Benzenamine, 5-methoxy-2-methyl- NSC 229308 5-Methoxy-2-methylaniline,97% Einecs 256-816-4 5-Methoxy-2-methylaniline,6-Methyl-m-anisidine 5-Methoxy-2-Methylanilin 5-METHOXY-2-METHYLANILINE 5-methoxy-o-toluidine 2-methyl-5-Methoxyaniline 5-Methoxy-2-methylaniline ISO 9001：2015 REACH 5-(Methoxy-d3)-2-methylaniline 2-amino-4-methoxytoluene 5-Methoxy-2-methylani 5-Methoxy-2-methylbenzeneamine 50868-72-9 AMINE Nitrogen Compounds Organic Building Blocks Amines Building Blocks C8 Amines Building Blocks C8 Chemical Synthesis Nitrogen Compounds Organic Building Blocks Anilines, Aromatic Amines and Nitro Compounds