Periodic acid
- CAS No.
- 10450-60-9
- Chemical Name:
- Periodic acid
- Synonyms
- ORTHOPERIODIC ACID;Periodate;periodic;Periodic acid, ACS, 99.01-101.0%;PERIODIC ACI;Periodic acid;PeriodicAcide;PeriodicAcidGr;PeriodicAcid50%;Periodic Acid, ACS
- CBNumber:
- CB3405103
- Molecular Formula:
- H5IO6
Lewis structure
- Molecular Weight:
- 227.94057
- MDL Number:
- MFCD00011344
- MOL File:
- 10450-60-9.mol
| Product description | Number | Pack Size | Price |
| Periodic acid for synthesis | 8.22288 | 100g | $149 |
| Periodic acid for synthesis | 8.22288 | 500g | $438 |
| Periodic acid ACS reagent, 99% | 375810 | 25g | $133 |
| Periodic acid ACS reagent, 99% | 375810 | 100g | $359 |
| Periodic acid for analysis EMSURE? | 1.00524 | 25g | $225 |
| More product size | |||
| Melting point | 122 °C (lit.) |
|---|---|
| Boiling point | 140°C |
| bulk density | 1400kg/m3 |
| Density | d417 1.3875; d 1.42 |
| vapor pressure | 7.6Pa at 25℃ |
| RTECS | NN1269700 |
| Flash point | 140°C |
| storage temp. | Store at +15°C to +25°C. |
| solubility | soluble in Methanol, Water |
| form | Solid |
| color | White to slightly yellow |
| PH | 1.2 (100g/l, H2O, 20℃) |
| Water Solubility | Soluble in water and alcohols. |
| Sensitive | Moisture & Light Sensitive |
| Merck | 14,7171 |
| Stability | Stable, but strong oxidizer. Contact with combustible material may cause fire. Hygroscopic. Incompatible with organic materials, strong reducing agents. |
| InChIKey | TWLXDPFBEPBAQB-UHFFFAOYSA-N |
| CAS DataBase Reference | 10450-60-9(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | PERIODIC ACID |
| FDA UNII | AK1D44L87G |
| EPA Substance Registry System | Periodic acid (H5IO6) (10450-60-9) |
| UNSPSC Code | 41105319 |
| NACRES | NB.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS03,GHS05,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H271-H314-H372-H410 | |||||||||
| Precautionary statements | P210-P260-P273-P280-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C,O | |||||||||
| Risk Statements | 8-34 | |||||||||
| Safety Statements | 26-27-36/37/39-45-17-36 | |||||||||
| RIDADR | UN 3264 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-8 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 2811 19 80 | |||||||||
| HazardClass | 5.1 | |||||||||
| PackingGroup | II | |||||||||
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) or 1.0 kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
Periodic acid price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.22288 | Periodic acid for synthesis | 10450-60-9 | 100g | $149 | 2025-07-31 | Buy |
| Sigma-Aldrich | 8.22288 | Periodic acid for synthesis | 10450-60-9 | 500g | $438 | 2025-07-31 | Buy |
| Sigma-Aldrich | 375810 | Periodic acid ACS reagent, 99% | 10450-60-9 | 25g | $133 | 2025-07-31 | Buy |
| Sigma-Aldrich | 375810 | Periodic acid ACS reagent, 99% | 10450-60-9 | 100g | $359 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1.00524 | Periodic acid for analysis EMSURE? | 10450-60-9 | 25g | $225 | 2025-07-31 | Buy |
Periodic acid Chemical Properties,Uses,Production
Chemical Properties
Periodic acid exists as colorless crystals, soluble in water and ethanol but slightly soluble in ether. Upon dehydration, it forms metaperiodic acid (HIO₄). Further dehydration leads to decomposition, ultimately yielding iodine pentoxide (I₂O₅).
Physical properties
In dilute solution, periodic acid exists as H+ and IO4-. When more concentrated, orthoperiodic acid, H5IO6, is formed. Note that this compound is essentially a dihydrate, HIO4·2H2O. This can be obtained as a crystalline solid. O-periodic acid can be dehydrated to metaperiodic acid, m-HIO4. Further heating gives di-iodine pentoxide (I2O5) and O2. The anhydride di-iodine heptoxide, i.e. I2O7, does not exist in nature but can be formed synthetically.
Uses
Periodic acid is used as a component for glycoprotein stains. It serves as a pharmaceutical and synthetic intermediate and is used in silk screen printing. It acts as an oxidizing agent especially the cleavage of 1,2 diols to prepare dialdehydes. It has selective oxidation powers which makes it an ideal reagent for the reclamation of silk screens in the printing industry. It finds application in life sciences for the analysis of intracellular polysaccharides like glycogen, starch and cellulose. Furthermore, it is used in the oxidation reactions converting sulfides into sulfones, catalyzed by chromium(VI) oxide and oxidation reactions converting alcohols to aldehydes and ketones.
Uses
PERIODIC ACID is used as an oxidiser and in the determination of manganese.
Uses
In organic synthesis.
Definition
ChEBI: Orthoperiodic acid is an iodine oxoacid. It is a conjugate acid of an orthoperiodate(1-).
Production Methods
A 100 g quantity of Ba₃H₄(IO₆)₂ is moistened with 75 mL of H₂O and treated with 200 mL of colorless nitric acid (HNO₃). The mixture is agitated, heated to 60–70 °C for 1 h, and then cooled to 30–40 °C. The precipitated Ba(NO₃)₂ is filtered off using a glass frit filter. The residue is washed free of periodate by stirring with concentrated HNO₃. The combined filtrate is evaporated at 60–70 °C under aspirator vacuum (if additional Ba(NO₃)₂ precipitates, it is removed by filtration, and evaporation continues) until H₅IO₆ begins to crystallize. After cooling, colorless, glistening crystals of periodic acid (H₅IO₆) form. Due to the tendency of the solution to become supersaturated, prolonged waiting may be required. The crystals are collected by filtration and dried under vacuum at 50 °C. A second crop of crystals may be obtained by further evaporating the mother liquor.
Reactions
Paraperiodic acid H5IO6, is obtained from sodium paraperiodate, formed by action of chlorine upon a NaOH solution containing I2. On vacuum drying, paraperiodic acid yields metaperiodic acid, HIO4, and dimesoperiodic acid, H4I2O9; which form heteropoly acids with a number of oxides and acids. The periodic acids and their salts are strong oxidizing agents both with inorganic and organic compounds.
General Description
Periodic acid (H5IO6) is an oxoacid of iodine. It is commonly used as an oxidizing agent in organic synthesis for the preparation of useful chemical intermediates. Periodic acid is also used in oxidative cleavage reactions.
Flammability and Explosibility
Not classified
reaction suitability
reagent type: oxidant
References
[1] JACKSON E. Periodic Acid Oxidation[J]. Organic Reactions, 2011, 104 1: 341-375. DOI:10.1002/0471264180.OR002.08.
[2] FATIADI A J. Periodic Acid, a Novel Oxidant of Polycyclic, Aromatic Hydrocarbons.[J]. Journal of Research of the National Bureau of Standards. Section A, Physics and Chemistry, 1968, 72A 4: 341-350. DOI:10.6028/jres.072A.030.
[3] MAHDIEH TABATABAEI SHAFIEI. Detecting glycogen in peripheral blood mononuclear cells with periodic acid schiff staining.[J]. Jove-Journal of Visualized Experiments, 2014, 94. DOI:10.3791/52199.
[4] ZACHARY J WOLNER Benjamin K S Danielle E Mustin. Preordering Periodic Acid-Schiff Staining: A Quality Improvement Study.[J]. American Journal of Dermatopathology, 2023: 825-827. DOI:10.1097/DAD.0000000000002570.
[5] SH. N. ZHURAKULOV. Oxidation of Quinoline Alkaloids Bucharaine, Foliosidine, Evoxine, and Dubinidine by Periodic Acid[J]. Chemistry of Natural Compounds, 2024, 60 4: 676-682. DOI:10.1007/s10600-024-04410-7.
Periodic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8770 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21616 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Changzhou Carman Chemical Co., Ltd. | 15061933924 | CHINA | 514 | 58 | |
| Shanghai Longyu Biotechnology Co., Ltd. | +8619521488211 | info@longyupharma.com | China | 2541 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from Periodic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-10 | PERIODIC ACID
10450-60-9
|
US $10.00 / KG | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-06-20 | PERIODIC ACID
10450-60-9
|
US $30.00-2.00 / kg | 1kg | 0.99 | 30 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2021-07-13 | Periodic Acid
10450-60-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- PERIODIC ACID
10450-60-9
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- PERIODIC ACID
10450-60-9
- US $30.00-2.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- Periodic Acid
10450-60-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
