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K-252C

CAS No.
85753-43-1
Chemical Name:
K-252C
Synonyms
K-252C;Staurosporonine;Staurosporinone;STAUROSPORINE AGLYCONE;K-252c(Staurosporinone);Staurosporinone, K-252c;K252c, Ready Made Solution;Staurosporine Aglycone >99%;K-252c - CAS 85753-43-1 - Calbiochem;Staurosporinone, Staurosporine Aglycone
CBNumber:
CB3406463
Molecular Formula:
C20H13N3O
Molecular Weight:
311.34
MDL Number:
MFCD00236435
MOL File:
85753-43-1.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

K-252C Properties

Melting point >200°C (dec.)
storage temp. −20°C
solubility DMSO: 10 mg/mL, soluble
form solid
color Pale Brown to Light Brown
Water Solubility Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water.
FDA UNII HAJ5XS5HPF

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Safety Statements  22-24/25
RIDADR  NA 1993 / PGIII
WGK Germany  3
HS Code  29333990
NFPA 704
0
2 0

K-252C price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 420305 K-252c 85753-43-1 1mg $289 2024-03-01 Buy
Alfa Aesar J63090 K252c, 99% 85753-43-1 5mg $465 2021-12-16 Buy
Alfa Aesar J63090 K252c, 99% 85753-43-1 1mg $104 2021-12-16 Buy
Cayman Chemical 13514 K-252c ≥98% 85753-43-1 1mg $87 2024-03-01 Buy
Cayman Chemical 13514 K-252c ≥98% 85753-43-1 5mg $341 2024-03-01 Buy
Product number Packaging Price Buy
420305 1mg $289 Buy
J63090 5mg $465 Buy
J63090 1mg $104 Buy
13514 1mg $87 Buy
13514 5mg $341 Buy

K-252C Chemical Properties,Uses,Production

Uses

Inhibits protein kinase C

Biological Activity

Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13-0.32 μ M). Shows no activity against herpes simplex virus (HSV).

storage

-20°C

References

1. fabre s, prudhomme m, rapp m. protein kinase c inhibitors; structure-activity relationships in k252c-related compounds. bioorg med chem 1993,1:193-196.2. hashimoto s. k-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in pc12h cells. j cell biol 1988,107:1531-1539.3. raychaudhuri sp, sanyal m, weltman h, kundu-raychaudhuri s. k252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. j invest dermatol 2004,122:812-819.

934506-84-0
85753-43-1
Synthesis of K-252C from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

K-252C Preparation Products And Raw materials

K-252C Suppliers

Global( 84)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30256 58
BOC Sciences
+16314854226 inquiry@bocsci.com United States 19743 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894 shawn@hirisunpharm.com CHINA 9923 58
Coresyn Pharmatech Co., Ltd.
+86-571-86626709 +86-18157142896 cbc@coresyn.com China 9991 58
Aurisco Pharmaceutical (Tianjin) Inc. 022-59885855 liuyujie@aurisco.com China 96 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 6013 61

K-252C Spectrum

K-252C STAUROSPORINE AGLYCONE Staurosporinone 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one Staurosporine Aglycone >99% Staurosporinone, K-252c K-252c(Staurosporinone) K252c / Staurosporine Aglycone>99%/ Staurosporinone, K-252C / 6,7,12,13-Tetrahydro-5H-Indolo[2,3-A]Pyrrolo[3,4-C]Carbazol-5-One K252c, Ready Made Solution Staurosporonine Staurosporinone, Staurosporine Aglycone K-252c - CAS 85753-43-1 - Calbiochem 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, 6,7,12,13-tetrahydro- 85753-43-1 C20H13N3O v-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Src) Kinase/Phosphatase Biology Non-Receptor Tyrosine Kinase Inhibitors BioChemical Cell Biology Cell Signaling and Neuroscience Inhibitor