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BAPTA

BAPTA structure

CAS No.: 85233-19-8

Chemical Name:: BAPTA

Synonyms: BAPTA;CS-2002;BAPTA,97%;BAPTA, >=98%;BAPTA, Free Acid;1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'- TETRAACETI;ETHYLENEDIOXYBIS(O-PHENYLENENITRILO)TETRAACETIC ACID;Ethylenebis(oxy-2,1-phenylenenitrilo)tetraacetic acid;1,2-Bis-(2-amino-phenoxy)ethane N,N,N',N'-tetraacetic;1,2-Bis-(2-Aminophenoxy) Ethane-N,N,N,-Tetra Acetic Acid

CBNumber:: CB3406887

Molecular Formula:: C22H24N2O10

Molecular Weight:: 476.43

MDL Number:: MFCD00036255

MOL File:: 85233-19-8.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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BAPTA Properties

Melting point	177-179 °C
Boiling point	575.89°C (rough estimate)
Density	1.4482 (rough estimate)
refractive index	1.6500 (estimate)
RTECS	MC0423000
storage temp.	2-8°C
solubility	Soluble in dimethyl sulfoxide
form	Powder
pka	1.40±0.10(Predicted)
color	White to off-white
Water Solubility	Soluble in water and sodium bicarbonate.
λmax	209 nm, 254 nm, 203 nm, 274 nm
Merck	14,957
BRN	5192406
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Biological Applications	Calcium indicators; zinc indicators; treating acute cell death,cerebral infarction,myocardial infarction,hepatonecrosis,kidney ischemic necrosis,necrotizing pancreatitis,amyloidosis,atherosclerosis,diseases characteriz
InChIKey	FTEDXVNDVHYDQW-UHFFFAOYSA-N
CAS DataBase Reference	85233-19-8(CAS DataBase Reference)
FDA UNII	K22DDW77C0

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

HS Code

29225090

NFPA 704

	1
2		0

BAPTA price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	14510	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid ≥96.0% (HPLC)	85233-19-8	100MG	$34.56	2024-03-01	Buy
Sigma-Aldrich	14510	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid ≥96.0% (HPLC)	85233-19-8	250MG	$82	2024-03-01	Buy
Sigma-Aldrich	14510	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid ≥96.0% (HPLC)	85233-19-8	1G	$153	2024-03-01	Buy
Sigma-Aldrich	14510	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid ≥96.0% (HPLC)	85233-19-8	50G	$3510	2024-03-01	Buy
TCI Chemical	B3895	1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid >97.0%(HPLC)	85233-19-8	1g	$134	2024-03-01	Buy

Product number	Packaging	Price	Buy
14510	100MG	$34.56	Buy
14510	250MG	$82	Buy
14510	1G	$153	Buy
14510	50G	$3510	Buy
B3895	1g	$134	Buy

BAPTA Chemical Properties,Uses,Production

Description

BAPTA free acid (85233-19-8) is a selective extracellular Ca2+ chelator. It is a widely used calcium sponge for chelating Ca2+?outside of intact cells.1 It’s a useful tool to probe the involvement of extracellular Ca2+ in cellular signaling.2,3 Non-cell-permeable.

Chemical Properties

White Solid

Uses

Highly selective calcium chelating reagent. Suitable for the spectrophotometric monitoring of Ca2+ levels.

Uses

As calcium chelator; 19F labelled forms for measurement of intracellular calcium.

Uses

BAPTA is a highly selective calcium chelating reagent. Lipophilic diesters of the chelating agent 1,2-Bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) are used for inhibition of proteolytic activities of certain metalloproteinases, calpain and TACE.

Definition

ChEBI: A polyamino carboxylic acid in which bis(carboxymethyl)nitrilo groups are bonded to C-2 and C-2' of 1,1'-[ethane-1,2-diylbis(oxy)]dibenzene.

General Description

In nature 1,2-Bis(2-Aminophenoxy)ethane-N,N,N′,N′-tetra acetic acid (BAPTA) is a main metabolic product of BAPTA -AM (BAPTA-tetra(actoxymethyl ester), a neuro protective agent in cerebral ischemia, in rats.BAPTA is an intercellular Ca²⁺ chelator.

Biological Activity

Selective calcium chelator.

storage

Store at +4°C

References

1) Munoz et al. (2015), Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus; PLoS One, 10(9) e0138008 2) Wozniak et al. (2017), Extracellular Ca2+ is Required for Fertilization in the African Clawed Frog, Xenopus laevis; PLoS One, 12(1) e0170405 3) Didiasova et al. (2015), STIM1/ORAI1-mediated Ca2+ Influx Regulates Enolase-1 Exteriorization; J. Biol. Chem., 290 11983

BAPTA Preparation Products And Raw materials

Raw materials

Sodium dithionite Ammonium hydroxide Hydrazinium hydroxide solution Acetonitrile Ethanol

N,N-Dimethylformamide 2-Nitrophenol N,N-Diisopropylethylamine Palladium Sodium iodide

Ethyl bromoacetate 1,2-Dibromoethane Hydrochloric acid Hydrogen Dichloromethane

Acetic acid Methanol Sodium hydroxide

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Preparation Products

BAPTA Suppliers

Global( 165)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19994	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Hefei Hirisun Pharmatech Co., Ltd	58
Henan Alfa Chemical Co., Ltd	58
Labnetwork lnc.	58
Alfa Chemistry	58
InvivoChem	58

View Lastest Price from BAPTA manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	1,2-Bis(2-Aminophenoxy)ethane-N,N,N",N"-tetraacetic acid 98% 85233-19-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2020-01-09	BAPTA 85233-19-8	US $6.68 / KG	1KG	97%-99%	1kg-1000kg	Career Henan Chemical Co

1,2-Bis(2-Aminophenoxy)ethane-N,N,N",N"-tetraacetic acid 98%
85233-19-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

BAPTA
85233-19-8
US $6.68 / KG
97%-99%
Career Henan Chemical Co

BAPTA Spectrum

BAPTA(85233-19-8)¹HNMR

85233-19-8(BAPTA)Related Search:

RHOD-2, AM BAPTA BAPTA-AM Fura 2-AM Fluo 3-AM

BAPTA TETRASODIUM SALT HYDRATE, 98+%,BAPTA-NA4,BAPTA, TETRASODIUM SALT BAPTA, 5,5'-DIBROMO-, TETRASODIUM SALT,5,5'-DIBROMO-BAPTA BAPTA POTASSIUM,BAPTA TETRAPOTASSIUM SALT,BAPTA(K+ SALT),BAPTA 4K BAPTA TETRAETHYL ESTER,BAPTA TETRAETHYL ESTER, 98+% FURA 2 PENTAPOTASSIUM SALT

FURA 2 1-[2-(5-CARBOXYOXAZOL-2-YL)-6-AMINOBENZOFURAN-5-OXY]-2-(2'-AMINO-5'-METHYLPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID, 5NA FLUO 3 INDO 1-AM NITR 5/AM

INDO 1 PENTAPOTASSIUM SALT BAPTA, TETRACESIUM SALT BAPTA-TMFM

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BAPTA ETHYLENEDIOXYBIS(O-PHENYLENENITRILO)TETRAACETIC ACID 1,2-BIS-(O-AMINOPHENOXY)-ETHANE-N,N,N',N'-TETRAACETIC ACID 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'-TETRAACETIC ACID BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid, 2,2μ-(Ethylenedioxy)dianiline-N,N,Nμ,Nμ-tetraacetic acid BAPTA, Ethylenedioxybis(o-phenylenenitrilo)tetraacetic acid 1,2-BIS(2-AMINOPHENOXY)-ETHANE-N,N,N',N'- TETRAACETIC ACID 97% 2,2',2'',2'''-[Ethylenebisoxybis(2,1-phenylenenitrilo)]tetrakisacetic acid Ethylenebis(oxy-2,1-phenylenenitrilo)tetraacetic acid 1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N',N'- TETRAACETI 1,2-Bis-(2-Aminophenoxy) Ethane-N,N,N,-Tetra Acetic Acid BAPTA (1,2-BIS(2-AMINOPHENOXY)ETHANE-N,N,N'',N'' -TETRAACETIC ACID) N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxyMethyl)glycine Glycine, N,N'-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxyMethyl)- 1,2-Bis(2-aMinophenoxy)ethane-N,N,N',N'-tetraacetic acid >=96.0% (HPLC) 2,2',2'',2'''-(((ETHANE-1,2-DIYLBIS(OXY))BIS(2,1-PHENYLENE))BIS(AZANETRIYL))TETRAACETIC ACID BAPTA, >=98% 2,2'-((2-(2-(3-(Bis(carboxymethyl)amino)phenoxy)-ethoxy)phenyl)azanediyl)diacetic acid 1,2-bis(2-aminophenoxy)ethane-n,n,n0, n0-tetraacetic Acid 1,2-bis(o-aminophenoxy)ethane-n,n, n0,n0-tetraacetic Acid 2,20-(ethylenedioxy)dianiline-n,n,n0, n0-tetraacetic Acid BAPTA, Free Acid 1,2-Bis(2-aminophenoxy)-ethane-N,N,N'N'-tetraacetic acid,97% BAPTA,97% CS-2002 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid > 1,2-Bis-(2-amino-phenoxy)ethane N,N,N',N'-tetraacetic 2-[2-[2-[2-[bis(carboxymethyl)amino]phenoxy]ethoxy]-N-(carboxymethyl)anilino]acetic acid 1,2-Bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic Acid 2,2',2'',2'''-(((Ethane-1,2-diylbis(oxy))bis(2,1-phenylene))bis(azanetriyl))tetraacetic acid 85233-19-8 C22H24N2O10 C22H20N2O10 Detection Fluorescent Probes, Labels, Particles and Stains Intracellular Calcium Signaling Cell Signaling and Neuroscience Cell Biology Calcium Chelators Calcium Signaling Research Tools BioChemical Biochemicals and Reagents Aromatic Amines Aromatics Chelating Agents & Ligands Fluorescent Labels & Indicators