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Tamsulosin hydrochloride

Description References
Tamsulosin hydrochloride
Tamsulosin hydrochloride structure
CAS No.
106463-17-6
Chemical Name:
Tamsulosin hydrochloride
Synonyms
Omic;OMNIC;PRADIF;YM-617;Yutana;FLOMAX;HARNAL;Yutanal;CS-1361;LY-253351
CBNumber:
CB3410080
Molecular Formula:
C20H29ClN2O5S
Formula Weight:
444.97
MOL File:
106463-17-6.mol

Tamsulosin hydrochloride Properties

Melting point:
228-230°C
alpha 
D24 -4.0° (c = 0.35 in methanol)
RTECS 
DB2430000
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
white powder
Merck 
14,9049
InChIKey
ZZIZZTHXZRDOFM-XFULWGLBSA-N
CAS DataBase Reference
106463-17-6(CAS DataBase Reference)
FDA UNII
11SV1951MR
NCI Dictionary of Cancer Terms
Flomax; tamsulosin hydrochloride
NCI Drug Dictionary
Flomax
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280a-P304+P340-P405-P501a-P261-P305+P351+P338-P301+P312+P330
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
HS Code  29350090

Tamsulosin hydrochloride price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000650 Tamsulosin hydrochloride European Pharmacopoeia (EP) Reference Standard 106463-17-6 $190 2021-03-22 Buy
Sigma-Aldrich PHR1524 Tamsulosin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 106463-17-6 200mg $285 2021-03-22 Buy
Sigma-Aldrich 1643260 Tamsulosin hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 106463-17-6 200mg $3510 2021-03-22 Buy
TCI Chemical T2749 Tamsulosin Hydrochloride >98.0%(HPLC)(T) 106463-17-6 100mg $37 2021-03-22 Buy
TCI Chemical T2749 Tamsulosin Hydrochloride >98.0%(HPLC)(T) 106463-17-6 1g $183 2021-03-22 Buy

Tamsulosin hydrochloride Chemical Properties,Uses,Production

Description

Tamsulosin hydrochloride is the hydrochloride form of Tamsulosin (Trade name: Alna ® / Flomax ®). It is a kind of medication used for the treatment of symptomatic benign prostatic hyperplasia (BPH), boosting the passage of kidney stones. It can also be used for the treatment of acute urinary retention. It is a kind of selective antagonist of alpha-1A and alpha-1B-adrenoceptros located in prostate, prostatic capsule, prostatic urethra, and bladder neck. The blockage of these receptors through Tamsulosin causes the relaxation of smooth muscles in the bladder neck and prostate.

References

https://www.drugbank.ca/drugs/DB00706
https://en.wikipedia.org/wiki/Tamsulosin

Chemical Properties

White to Off-White Solid

Originator

Contiflo OD,Ranbaxy Laboratories,India

Uses

Specific a1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy

Uses

Specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.

Uses

antineoplastic, alkylating agent

Uses

(R)-Tamsulosin is a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.

Uses

An α1-adrenoceptor antagonist

Manufacturing Process

In 1,000 ml of acetonitrile was suspended 17 g of 5-{2-[2-(2- ethoxyphenoxy)ethylamino]-1-hydroxy-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride and while stirring the suspension, 9 g of thionyl chloride was added dropwise to the suspension at room temperature, whereby the product first dissolved and then began to crystallize gradually. After stirring the mixture for two days, the crystals formed were recovered by filtration, washed with chloroform and dried to provide 15 g of 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride. Melting point: 197°-200°C.
In methanol was dissolved the 5-{1-chloro-2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}-2-methoxybenzenesulfonamide hydrochloride and after adding thereto 10% palladium carbon, dechlorination was performed under hydrogen stream at normal temperature and pressure. The palladium carbon was filtered away and the filtrate was concentrated under reduced pressure to provide the 2-methoxy-5-{2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}benzenesulfonamide hydrochloride, which was recrystallized from 120 ml of a mixture of methanol and ethanol (1:4 by volume ratio) to provide the colorless crystals thereof. The melting point of the 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride: 254°-256°C.

Therapeutic Function

Antihypertensive

Hazard

Moderately toxic by ingestion.

Biological Activity

Selective α 1A -adrenoceptor antagonist (pK i values are 9.97, 9.64 and 8.86 for α 1A , α 1B and α 1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo .

Tamsulosin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Tamsulosin hydrochloride Suppliers

Global( 333)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Zhejiang ZETian Fine Chemicals Co. LTD
18957127338
stella@zetchem.com CHINA 2007 58
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3004 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58

View Lastest Price from Tamsulosin hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-03 Tamsulosin Hydrochloride
106463-17-6
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-09-29 Tamsulosin hydrochloride
106463-17-6
US $0.00-0.00 / KG 10g 99%min 10kg WUHAN FORTUNA CHEMICAL CO., LTD
2021-07-20 Tamsulosin hydrochloride
106463-17-6
US $1.00-1.00 / KG 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd

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