β-Caryophyllene

β-Caryophyllene Properties

Melting point	<25℃
alpha	D -8 to -9° (chloroform)
Boiling point	129-130 °C/14 mmHg (lit.)
Density	0.901 g/mL at 25 °C (lit.)
vapor pressure	6Pa at 20℃
FEMA	2252 \| BETA-CARYOPHYLLENE
refractive index	n20/D 1.5(lit.)
Flash point	205 °F
storage temp.	-20°C
solubility	Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
color	Colourless
Specific Gravity	0.90
Odor	at 100.00 %. sweet woody spice clove dry
Odor Type	spicy
optical activity	[α]23/D 7.5°, neat
Water Solubility	88μg/L at 20℃
Merck	14,1875
JECFA Number	1324
BRN	2044564
Stability	Light Sensitive
LogP	6.23 at 25℃
Substances Added to Food (formerly EAFUS)	BETA-CARYOPHYLLENE
FDA 21 CFR	172.515
CAS DataBase Reference	87-44-5(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	BHW853AU9H
EPA Substance Registry System	Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)- (87-44-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H304-H317

Precautionary statements

P261-P272-P280-P301+P310-P302+P352-P331

Risk Statements

36/37/38

Safety Statements

26-36-24/25

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

1

RTECS

DT8400000

HS Code

29021990

NFPA 704

	1
0		0

β-Caryophyllene price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	W225299	β-Caryophyllene natural, ≥80%, FG	87-44-5	SAMPLE-K	$56	2024-03-01	Buy
Sigma-Aldrich	W225299	β-Caryophyllene natural, ≥80%, FG	87-44-5	1KG	$117	2024-03-01	Buy
Sigma-Aldrich	W225299	β-Caryophyllene natural, ≥80%, FG	87-44-5	9KG	$526	2024-03-01	Buy
Sigma-Aldrich	W225299	β-Caryophyllene natural, ≥80%, FG	87-44-5	20KG	$656	2024-03-01	Buy
Sigma-Aldrich	W225207	β-Caryophyllene ≥80%, FCC, FG	87-44-5	1kg	$79.8	2024-03-01	Buy

Product number	Packaging	Price	Buy
W225299	SAMPLE-K	$56	Buy
W225299	1KG	$117	Buy
W225299	9KG	$526	Buy
W225299	20KG	$656	Buy
W225207	1kg	$79.8	Buy

β-Caryophyllene Chemical Properties,Uses,Production

Description

β-Caryophyllene (Item No. 21572) is a sesquiterpene that has been found in plants, including C. sativa, C. indica, and hemp, and has diverse biological activities, including lipid metabolic, antioxidant, anti-neuroinflammatory, anti-proliferative, and antinociceptive properties. It is an agonist of the cannabinoid (CB) receptor CB₂ (K_i = 155 nM) that inhibits cAMP production induced by forskolin in CHO-K1 cells expressing CB₂ receptors (EC₅₀ = 38 nM). β-Caryophyllene is also an agonist of peroxisome proliferator-activated receptor α (PPARα; EC₅₀ = 9.58 μM in a reporter assay). β-Caryophyllene (1 and 2.5 μM) reduces the production of reactive oxygen species (ROS) in and protects against cytotoxicity of SH-SY5Y cells induced by 1-methyl-4-pheylpyridinium (MPP⁺). It also decreases the β-amyloid burden in the hippocampus and cerebral cortex and improves memory in an APP/PS1 transgenic mouse model of Alzheimer’s disease, decreasing the latency to find the platform in the Morris water maze during training and increasing the time spent in the target quadrant during testing when administered at a dose of 48 mg/kg per day. β-Caryophyllene (50 mg/kg) increases the number of entries into and the time spent in the open arms of the elevated plus maze and the time spent immobile in the forced swim test, indicating anxiolytic-like and antidepressant-like activity, effects that can be blocked by the CB₂ receptor antagonist AM630 .

Chemical Properties

β-Caryophyllene has a woody-spicy, dry, clove-like aroma.

Chemical Properties

Clear colorless liquid

Occurrence

Three isomers (α-, β-, and γ-caryophyllene) are found in nature. The β-isomer is the most frequently encountered and most abundant. This sesquiterpene hydrocarbon occurs naturally in approximately 60 essential oils, mainly in that of cloves, from which it was originally isolated. The chemical structure has been thoroughly studied; other studies have been conducted on the isolation and the dipolar moment, as well as on its oxide. Reported found in lime peel oil, lemon, grapefruit, guava fruit, raspberry, black currant, carrot, celery seed, cinnamon bark, anise, nutmeg, cumin seed, ginger, pepper, peppermint oil, mace, laurel and caraway herb.

Uses

β-Caryophyllene is notable for having a cyclobutane ring, a rarity in nature. β-Caryophyllene is one of the chemical compounds that contributes to the spiciness of black pepper. β-Caryophyllene was shown to selectively bind to the cannabinoid receptor type-2 (CB2) and to exert significant cannabimimetic antiinflammatory effects in mice.

Preparation

Isolated from oil of clove stems and separated from eugenol by treating the oil with 7% sodium carbonate solution, extracting with ether, repeating the carbonate treatment on the concentrated extracts, and finally steam distilling.

Definition

ChEBI: A beta-caryophyllene in which the stereocentre adjacent to the exocyclic double bond has S configuration while the remaining stereocentre has R configuration. It is the most commonly occurring form of <greek beta-caryophyllene, occurring in many essential oils, particularly oil of cloves.

Aroma threshold values

Detection at 64 to 90 ppb

Taste threshold values

Taste characteristics at 50 ppm: spicy, pepper-like, woody, camphoraceous with a citrus background.

Synthesis Reference(s)

Journal of the American Chemical Society, 86, p. 485, 1964 DOI: 10.1021/ja01057a040

General Description

Pale yellow oily liquid with an odor midway between odor of cloves and turpentine.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

The unsaturated aliphatic hydrocarbons, such as BETA-CARYOPHYLLENE, are generally much more reactive than the alkanes. Strong oxidizers may react vigorously with them. Reducing agents can react exothermically to release gaseous hydrogen. In the presence of various catalysts (such as acids) or initiators, compounds in this class can undergo very exothermic addition polymerization reactions.

Fire Hazard

BETA-CARYOPHYLLENE is combustible.

Safety Profile

A skin irritant. Combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes.

Carcinogenicity

Caryophyllene showed significant activity as an inducer of the detoxifying enzyme glutathione S-transferase in the mouse liver and small intestine. The ability of natural anticarcinogens to induce detoxifying enzymes has been found to correlate with their activity in the inhibition of chemical carcinogenesis (253a).

β-Caryophyllene Preparation Products And Raw materials

Raw materials

CLOVE STEM OIL Cassia Aurantium P.E Catechins 8% HPLC EUGENIA CARYOPHYLLUS (CLOVE) LEAF OIL

Preparation Products

Caryophyllenolexcloveleafoil (-)-ALPHA-NEOCLOVENE ALPHA-CARYOPHYLLENE

β-Caryophyllene Suppliers

Global( 385)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	5993	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5964	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	1696	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	sales@dolonchem.com	CHINA	2972	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Hebei Guanlang Biotechnology Co,.LTD	58
Henan Bao Enluo International TradeCo.，LTD	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Nanjing Dolon Biotechnology Co.,Ltd.	58

View Lastest Price from β-Caryophyllene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-24	Beta-Caryophyllene 87-44-5	US $10.00 / kg	1kg	99.6%	100000	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-03-28	β-Caryophyllene 87-44-5	US $0.00 / kg	25kg	98%	Inquiry	PNP Biotech Co. Ltd
2023-10-11	β-Caryophyllene 87-44-5	US $0.00-0.00 / kg	1kg	0.99	50000kg	Hebei Yibangte Import and Export Co. , Ltd.

Beta-Caryophyllene
87-44-5
US $10.00 / kg
99.6%
Ouhuang Engineering Materials (Hubei) Co., Ltd

β-Caryophyllene
87-44-5
US $0.00 / kg
98%
PNP Biotech Co. Ltd

β-Caryophyllene
87-44-5
US $0.00-0.00 / kg
0.99
Hebei Yibangte Import and Export Co. , Ltd.

β-Caryophyllene Spectrum

BETA-CARYOPHYLLENE(87-44-5)FT-IR BETA-CARYOPHYLLENE(87-44-5)IR

87-44-5(β-Caryophyllene)Related Search:

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CARYOPHYLLENE, (-)-trans-(SG) HUMULENE, alpha-(SG) 8-METHYLENE-4,11,11-TRIMETHYLBICYCLO-UNDEC-4-ENE CAROPHYLENE BETA-CARYPOPHYLLENE CARYOPHYLLEN BETA NATUERLICH NATURAL β-CARYOPHYLLENE B-CARYOPHYLLENE, NATURAL 8-METHYLENE-4,11,11-TRIMETHYLBICYCLO[7.2.0]UNDEC-4-ENE FCC (-)-TRANS-CARYOPHYLLENE WITH GC BETA-CARYOPHYLLENE 80+% FCC (1R,9S)-8-METHYLEN-4,11,11-TRIMETHYL-BICYCLO[7.2.0]UNDEC-4-ENE 8-METHYLENE-4,11,11-TRIMETHYLBICYCLO[7.2.0]UNDEC-4-ENE BETA-CARYOPHYLLEN BETA-CARYOPHYLLENE CARYOPHYLLENE, (-)-TRANS- FEMA 2252 TRANS-(1R,9S)-8-METHYLENE-4,11,11-TRIMETHYLBICYCLO[7.2.0]UNDEC-4-ENE (-) TRANS CARYOPHYLLEN (-)-TRANS-CARYOPHYLLENE (-)-E-caryophyllene (E)-beta-Caryophylene [1R-(1R*,4E,9S*)]-4,11,11-trimethyl-8-methylene-bicyclo[7.2.0]-4-undecene [1R-(1R*,4E,9S*)]-8-methylene-4,11,11-trimethylbicyclo[7.2.0]-4-undecane 4,11,11-trimethyl-8-methylene-,(1r-(1r*,4e,9s*))-bicyclo(7.2.0)undec-4-en 4,11,11-trimethyl-8-methylene-,[1R-(1R*,4E,9S*)]-Bicyclo[7.2.0]undec-4-ene 8-methylene-4,11,11-trimethyl-,(e)-(1r,9s)-(-)-bicyclo(7.2.0)undec-4-en beta-(E)-Caryophyllene beta-cariofillene beta-trans-caryophyllene Bicyclo(7.2.0)undec-4-ene, 8-methylene-4,11,11-trimethyl-, (E)-(1R,9S)-(-)- Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, [1R-(1R*,4E,9S*)]- Caryophyllene (E) CARYOPHYLLENE ,alpha + beta MIXT. E-beta-caryophyllene t-.beta.-caryophyllene (1R,4E,9S)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene (E,1R,9S)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene 1R-(1R*,4E,9S*)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene trans-(1R,9S)-8-Methylene-4,11,11-trimethylbicyclo[7.2.0] B-Caryophyllene Fcc ()-trans-Caryophyllene,β-Caryophyllene, trans-(1R,9S)-8-Methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene β-Caryophyllene,()-trans-Caryophyllene, trans-(1R,9S)-8-Methylene-4,11,11-trimethylbicyclo[7.2.0]undec-4-ene β-Caryophyllene, froM CinnaMoMuM caMphora (-)-trans-Caryophyllene >=98.5% (suM of enantioMers, GC) β-Caryophyllene Beta-87-44-5 factory Direct Salebest in Quality NATURAL B-CARYOPHYLLENE TIANFU CHEM-- BETA-CARYOPHYLLENE (1R,9S,E)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene beta-Caryophyllene solution Eugenol EP Impurity A β-Caryophyllene, 90%, from Cinnamomum camphora (L.) J. Presl β-Caryophyllene ( (-)-trans-Caryophyllene) (-)-trans-Caryophyllene Solution (-)-trans-Caryophyllene@100 μg/mL in Methanol (-)-β-caryophyllene BETA-CARYOPHYLLENE USP/EP/BP