ChemicalBook >> CAS DataBase List >>L-NORADRENALINE BITARTRATE
L-NORADRENALINE BITARTRATE
- CAS No.
- 108341-18-0
- Chemical Name:
- L-NORADRENALINE BITARTRATE
- Synonyms
- NORADRENALINE;L-ARTERENOL BITARTRATE;Epinephrine Impurity 28;L-Nradrenaline bitartrate;L-NORADRENALINE BITARTRATE;Noradrenaline tartrate CRS;L-NOREPINEPHRINE BITARTRATE;(-)-ARTERENOL BITARTRATE SALT;NOREPINEPHRINE BITARTRATE USP;L-Arterenol hydrogen L-tartrate
- CBNumber:
- CB3417135
- Molecular Formula:
- C12H17NO9
- Molecular Weight:
- 319.27
- MDL Number:
- MFCD00036384
- MOL File:
- 108341-18-0.mol
Last updated:2025-09-08 11:55:05
| Melting point | 100-104 °C(lit.) |
|---|---|
| refractive index | -11 ° (C=5, H2O) |
| storage temp. | Refrigerator |
| solubility | H2O: soluble50mg/mL, clear |
| pka | 8.64(at 25℃) |
| form | solid |
| color | white |
| optical activity | [α]20/D 11.5±1°, c = 2% in H2O |
| Water Solubility | water: 1mg/mL |
| BRN | 4078502 |
| InChI | InChI=1/C8H11NO3.C4H6O6/c9-4-8(12)5-1-2-6(10)7(11)3-5;5-1(3(7)8)2(6)4(9)10/h1-3,8,10-12H,4,9H2;1-2,5-6H,(H,7,8)(H,9,10)/t8-;1-,2-/s3 |
| InChIKey | WNPNNLQNNJQYFA-KBOIKTAVNA-N |
| SMILES | [C@H](C1C=CC(O)=C(O)C=1)(O)CN.[C@H](O)(C(=O)O)[C@@H](O)C(=O)O |&1:0,12,17,r| |
| FDA UNII | IFY5PE3ZRW |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310 | |||||||||
| Precautionary statements | P262-P280-P301+P310+P330-P302+P352+P310 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28-28 | |||||||||
| Safety Statements | 22-26-36/37/39-45-36/37-28 | |||||||||
| RIDADR | UN 2811 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DN6750000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2937901500 | |||||||||
| NFPA 704 |
|
L-NORADRENALINE BITARTRATE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR3820 | Norepinephrine Bitartrate certified reference material, pharmaceutical secondary standard | 108341-18-0 | 250MG | $160 | 2025-07-31 | Buy |
| Sigma-Aldrich | N1100000 | Noradrenaline tartrate European Pharmacopoeia (EP) Reference Standard | 108341-18-0 | 200 mg | $164 | 2025-07-31 | Buy |
| Sigma-Aldrich | 1468501 | Norepinephrine bitartrate United States Pharmacopeia (USP) Reference Standard | 108341-18-0 | 125mg | $384 | 2025-07-31 | Buy |
| Sigma-Aldrich | 74500 | L-Norepinephrine hydrogen L-tartrate monohydrate ≥99.0% (sum of enantiomers, HPLC) | 108341-18-0 | 1g | $212 | 2023-06-20 | Buy |
| TCI Chemical | A0906 | L-Noradrenaline Bitartrate Monohydrate >98.0%(T) | 108341-18-0 | 1g | $160 | 2025-07-31 | Buy |
L-NORADRENALINE BITARTRATE Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Demethylated precursor of epinephrine (adrenaline). It is a sympathomimetic hormone produced by the adrenal gland.
Uses
A demethylated precursor of epinephrine.
Uses
Noradrenaline bitartrate monohydrate (Levophed) is a direct alpha-adrenergic receptors stimulator. Noradrenaline bitartrate monohydrate (Levophed) also directly stimulates the beta-adrenergic receptors of the heart (beta1-adrenergic receptors), but not th
Biochem/physiol Actions
Norepinephrine bitartrate plays an important role in in vivo and in vitro development of pathogenic and indigenous bacteria. It acts as a vasoconstrictor and adrenergic neurotransmitter.
in vivo
Norepinephrine bitartrate monohydrate can be used to induce cardiomyopathy[5][6]
Induced Cardiomyopathy Model[5][6]
Background
Norepinephrine bitartrate monohydrate is a potent growth factor for cardiomyocytes. Long-term infusion of subhyperbaric doses of Norepinephrine bitartrate monohydrate in animals can cause increases in myocardial mass and left ventricular wall thickness. Norepinephrine bitartrate monohydrate activates the Raf-1 kinase/MAP kinase cascade through α1- and β-adrenergic stimulation, and signaling pathways from both receptors synergistically induce cardiomyocyte hypertrophy.
Specific Modeling Methods
Rat: Spragues-Dawley rats ? adult (6 months old) ? male
Administration: Continuously injected via an osmotic minipump ? 100 μg/kg/h or 200 μg/kg/h (Norepinephrine)
Modeling Indicators
Molecular changes: Left ventricular Dnmt activity ↑; ROS generation ↑; lactate dehydrogenase release ↑; dystrophin expression ↑; FHL2 protein expression ↓
Gene Expression: Expression of Dnmt1, 3a, and 3b ↑; mRNA expression of fetal genes ANP, BNP, and βMHC in left ventricle ↑
Phenotypic observation: Myocardial infarction area ↑; blood pressure continues to rise; left ventricular mass ↑; left ventricular development pressure ↓; cardiac contractility ↓. Cardiac hypertrophy.
Correlated Product(s): /
Opposite Product(s): 5-Aza-2’-deoxycytidine (HY-A0004), Prazosin (HY-B0193), Propranolol (HY-B0573B)
IC 50
α1-adrenergic receptor; α2-adrenergic receptor; Beta-1 adrenergic receptor; Microbial Metabolite; Human Endogenous Metabolite
L-NORADRENALINE BITARTRATE Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 235)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| airuikechemical co., ltd. | +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Moxin Chemicals | +8617320513646 | Anna@molcoo.com | China | 9902 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32430 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7919 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 5963 | 58 |
View Lastest Price from L-NORADRENALINE BITARTRATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-08 | Norepinephrine bitartrate monohydrate
108341-18-0
|
US $33.00-54.00 / mg | 99.57% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-09-08 | Norepinephrine bitartrate monohydrate
108341-18-0
|
US $33.00-54.00 / mg | 99.57% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-09-08 | L-Norepinephrine bitartrate
108341-18-0
|
US $0.00-0.00 / Kg/Bag | 100g | 97%-102%;USP | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Norepinephrine bitartrate monohydrate
108341-18-0
- US $33.00-54.00 / mg
- 99.57%
- TargetMol Chemicals Inc.
-
- Norepinephrine bitartrate monohydrate
108341-18-0
- US $33.00-54.00 / mg
- 99.57%
- TargetMol Chemicals Inc.
-
- L-Norepinephrine bitartrate
108341-18-0
- US $0.00-0.00 / Kg/Bag
- 97%-102%;USP
- WUHAN FORTUNA CHEMICAL CO., LTD
108341-18-0(L-NORADRENALINE BITARTRATE)Related Search:
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L-ADRENALINE BITARTRATE
L-NORADRENALINE BITARTRATE
N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE
L-NORADRENALINE HYDROCHLORIDE
1of4
L-Arterenol hydrogen L-tartrate
L-Norepinephrine bitartrate salt
Levarterenol bitartrate monohydrate
4-[(1R)-2-amino-1-hydroxyethyl]-1,2-Benzenediol (2R,3R)-2,3-dihydroxybutanedioate hydrate (1:1:1)
L-NORADRENALINE BITARTRATE
L-(-)-NOREPINEPHRINE-(+)-BITARTRATE
L-NOREPINEPHRINE BITARTRATE
L-ARTERENOL BITARTRATE
L-4-(A-HYDROXY-B-AMINOETHYL)CATECHOL BITARTRATE
(-)-ARTERENOL BITARTRATE SALT
R(-)-4-(2-AMINO-1-HYDROXYETHYL)-1,2-BENZENEDIOL-(+)-TARTRATE
L-(-)-Norepinephrine (bitartrate hydrate)
(R)-(-)-norepinephrine L-bitartrate monohydrate,
(R)-(?-Norepinephrine L-bitartrate monohydrate
norepinephrine hydrogen tartrate monohydrate
L-(-)-Noradrenaline monohydrate (+)-bitartrate salt
L-(-)-Norepinephrine monohydrate (+)-bitartrate salt
L-Norepinephrine bitartrate hydride
L-Nradrenaline bitartrate
NOREPINEPHRINE BITARTRATE USP
(R)-(-)-NOREPINEPHRINE L-BITARTRATE &
NOREPINEPHRINE BITARTRATE MONOHYDRATE*20 0 MG PER VI
L-NORADRENALINE BITARTRATE 98+%
4-[(1R)-2-AMino-1-hydroxyethyl]-1,2-benzenediol Hydrogen Tartrate Monohydrate
L-Arterenol Bitartrate Monohydrate
Levoarterenol Bitartrate Monohydrate
L-Arterenol Bitartrate
L-Norepinephrine Bitartrate
Noradrenaline bitartrate Monohydrate (Levophed)
Norepinephrine (bitartrate Monohydrate)
1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, (2R,3R)-2,3-dihydroxybutanedioate, hydrate (1:1:1)
4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol (L-(+))-bitartrate salt
L-()-Norepinephrine (+)-bitartrate salt monohydrate L-(-)-
Noradrenaline tartrate CRS
L-Noradrenaline Bitartrate Monohydrate>
Noradrenaline bitartrate（L-Noradrenaline bitartrate monohydrate）
）
L-NORADRENALINE BITARTRATE USP/EP/BP
L-NORADRENALINE BITARTRATE 108341-18-0
Norepinephrine Bitartrate (1468501)
NORADRENALINE
Epinephrine Impurity 28
Noradrenaline Tartrate Monohydrate
Noradrenaline Acid Tartrate / Norepinephrine Acid Tartrate
Norepinephrine bitartrate monohydrate,Autophagy,Levarterenol bitartrate,Norepinephrine bitartrate,Beta Receptor,L-Noradrenaline bitartrate,Inhibitor,inhibit,Adrenergic Receptor,Endogenous Metabolite
1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)-,(2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt), monohydrate
(–)-Norepinephrine (bitartrate hydrate)
Adrenaline Tartrate EP Impurity B as Tartrate Monohydrate
Norepinephrine bitartrate hydrate
(R)-4-(2-amino-1-hydroxyethyl)benzene-1,2-diol (2R,3R)-2,3-dihydroxysuccinate hydrate
Norepinephrine bitartrate monohydrate, 10 mM in DMSO
L- (?)-Norepinephrine (+)-bitartrate salt monohydrate
(S)-2-amino-1-(4-methoxyphenyl)ethan-1-ol
108341-18-0
51-41-2;51-40-1
C12H17NO9H2O
HO2C6H3CHCH2NH2OHC4H6O6H2O
C12H17NO9
Levophed
Aromatics
