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Somatostatin

Somatostatin
Somatostatin structure
CAS No.
51110-01-1
Chemical Name:
Somatostatin
Synonyms
SRIF;GH-RIF;ay24910;panhibin;CCRIS 3629;Somatostatin;AGCKNFFWKTFTSC;SOMATOSTATIN-14;SOMATOSTATIN [GIF];SOMATOSTATIN [TYR1]
CBNumber:
CB3417645
Molecular Formula:
C76H104N18O19S2
Formula Weight:
1637.88
MOL File:
51110-01-1.mol

Somatostatin Properties

storage temp. 
−20°C
solubility 
H2O: 1 mg/mL
form 
powder
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  WF8751700
3-10-21

Somatostatin Chemical Properties,Uses,Production

Indications

Somatostatin (or somatotropin release–inhibiting factor [SRIF]) occurs primarily as a 14–amino acid peptide, although a 28–amino acid form also exists.As with the other hypothalamic peptides, it is formed by proteolytic cleavage of a larger precursor. Somatostatin, originally isolated from the hypothalamus, is also in many other locations, including the cerebral cortex, brainstem, spinal cord, gut, urinary system, and skin. Somatostatin inhibits the secretion of many substances in addition to growth hormone.

General Description

Somatostatin was discovered in the hypothalamus. It is elaboratedby the δ-cells of the pancreas and elsewhere in thebody. Somatostatin is an oligopeptide (14 amino acidresidues) and is referred to as somatotropin release–inhibitingfactor (SRIF).
Its primary action is inhibiting the release of GH from thepituitary gland. Somatostatin also suppresses the release ofboth insulin and glucagon. It causes a decrease in bothcAMP levels and adenylate cyclase activity. It also inhibitscalcium ion influx into the pituitary cells and suppressesglucose-induced pancreatic insulin secretion by activatingand deactivating potassium ion and calcium ion permeability,respectively. The chemistry, SARs, and potential clinicalapplications have been reviewed.

Clinical Use

Somatostatin has a very brief half-life in serum and is not useful clinically.An 8–amino acid analogue with 2 D-amino acids substituted for the naturally occurring L-amino acids is more stable, and monthly injections of a depot form of this analogue (octreotide, Sandostatin LAR) have several uses. Long-acting octreotide is used to treat acromegaly, as described earlier. It is also used to counteract unpleasant effects caused by overproduction of secreted bioactive substances produced by neuroendocrine tumors, including hyperinsulinemia from insulinomas and secretions from carcinoid tumors that cause severe diarrhea. Octreotide may also control severe diarrhea associated with AIDS that has not responded to other treatments.

Side effects

Transient side effects, gastrointestinal discomfort and decreased glucose tolerance, usually last only a few weeks after initiation of therapy. The most significant side effect associated with prolonged use of octreotide is formation of gallstones resulting from reduced bile flow.

Somatostatin Preparation Products And Raw materials

Raw materials

Preparation Products


Somatostatin Suppliers

Global( 98)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21821 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22626 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24723 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30045 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17852 58
Kunming jida pharmaceutical co. LTD 86-0871-68356968 0871-68356968
jidamd@jida.com.cn China 6 58
Hangzhou Peptidego Biotech Co.,Ltd. 0571-87213919-
0571-87213919 eric@peptidego.com China 2683 58

View Lastest Price from Somatostatin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-23 Somatostatin
51110-01-1
US $1.00 / g 1g 99% 800 Kilogram/Kilograms per Month Cangzhou Wanyou New Material Technology Co.,Ltd
2018-07-24 Somatostatin
51110-01-1
US $20.00 / MG 1G 99% 10g career henan chemical co

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