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(+)-Bicuculline

(+)-Bicuculline
(+)-Bicuculline structure
CAS No.
485-49-4
Chemical Name:
(+)-Bicuculline
Synonyms
NSC 3219;bicucullin;NSC 32192);Bucuculline;BICUCULLINE;D-BICUCULLINE;(+)-BICUCULINE;(+)-BICUCULLINE;PLUS-BICUCULLINE;(+)-Bicuculline,98%
CBNumber:
CB3418662
Molecular Formula:
C20H17NO6
Formula Weight:
367.35
MOL File:
485-49-4.mol

(+)-Bicuculline Properties

Melting point:
193-197 °C
alpha 
D25 +130.5° (CHCl3)
Boiling point:
497.92°C (rough estimate)
Density 
1.3694 (rough estimate)
refractive index 
1.5600 (estimate)
storage temp. 
2-8°C
form 
Off-white to yellow powder.
pka
4.84(at 25℃)
optical activity
[α]20/D +126±6°, c = 1% in chloroform
λmax
325nm(lit.)
Merck 
14,1203
BRN 
98786
InChIKey
IYGYMKDQCDOMRE-ZWKOTPCHSA-N
CAS DataBase Reference
485-49-4(CAS DataBase Reference)
FDA UNII
Y37615DVKC
EPA Substance Registry System
Furo[3,4-e]-1,3-benzodioxol-8(6H)-one, 6-[(5S)-5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, (6R)- (485-49-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H401
Precautionary statements  P261-P264-P270-P271-P273-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P403+P233-P405-P501
Hazard Codes  T,N,Xn
Risk Statements  23/24/25-50-36/37/38-20/21/22
Safety Statements  36/37-45-61-36-26
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  LV0909840
10-23
HazardClass  6.1(b)
PackingGroup  III
HS Code  29399990
Toxicity LD50 ipr-mus: 8480 mg/kg CUTOEX 1,199,93

(+)-Bicuculline price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 14340 (+)-Bicuculline ≥97.0% (TLC) 485-49-4 25mg $64.8 2021-03-22 Buy
Sigma-Aldrich 14340 (+)-Bicuculline ≥97.0% (TLC) 485-49-4 100mg $100 2021-03-22 Buy
TCI Chemical B1890 (+)-Bicuculline >98.0%(HPLC)(T) 485-49-4 25mg $54 2021-03-22 Buy
TCI Chemical B1890 (+)-Bicuculline >98.0%(HPLC)(T) 485-49-4 100mg $160 2021-03-22 Buy
Cayman Chemical 11727 Bicuculline ≥98% 485-49-4 50mg $35 2021-03-22 Buy

(+)-Bicuculline Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

GABAA receptor antagonist.

Uses

GABAa antagonist

Uses

Alkaloid naturally occurring in the d-form. Shows GABA antagonist activity.

Biological Activity

Classical GABA A antagonist.

Safety Profile

A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx.

Purification Methods

It crystallises from CHCl3/MeOH as plates. The crystals melt at 177o, then solidify and re-melt at 193-195o [Manske Canad J Research 21B 13 1943]. It is soluble in CHCl3, *C6H6, EtOAc but sparingly soluble in EtOH, MeOH and Et2O. [Stereochem: Blaha et al. Collect Czech Chem Commun 29 2328 1964, Snatzke et al. Tetrahedron 25 5059 1969, Pharmcol: Curtis et al. Nature 266 1222 1970, Beilstein 27 III/IV 1900].

(+)-Bicuculline Preparation Products And Raw materials

Raw materials

Preparation Products


(+)-Bicuculline Suppliers

Global( 245)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
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Hubei Jusheng Technology Co.,Ltd.
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027-59599243 linda@hubeijusheng.com CHINA 28229 58
Shaanxi Pioneer Biotech Co., Ltd .
86-13259417953(Whatsapp/Wechat) 86-13259417953(Whatsapp)
029-84385017 sales@pioneerbiotech.com CHINA 3001 58
BOC Sciences
1-631-485-4226
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Chongqing Chemdad Co., Ltd
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Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58

View Lastest Price from (+)-Bicuculline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 (+)-Bicuculline
485-49-4
US $5.00 / KG 1KG 99% 100 tons/months Wuhan wingroup Pharmaceutical Co., Ltd
2021-07-20 (+)-Bicuculline
485-49-4
US $1.00-1.00 / Kg/Bag 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-11 (+)-Bicuculline USP/EP/BP
485-49-4
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

(+)-Bicuculline Spectrum


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