ChemicalBook >> CAS DataBase List >>9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER

CAS No.
37497-47-5
Chemical Name:
9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER
Synonyms
RJXVYMMSQBYEHN-LVXZDWGESA-N;PROSTAGLANDIN E2-1-GLYCERYL ESTER;9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER;Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, 2,3-dihydroxypropyl ester, (5Z,11α,13E,15S)-
CBNumber:
CB3422395
Molecular Formula:
C23H38O7
Molecular Weight:
426.54
MDL Number:
MFCD05863940
MOL File:
37497-47-5.mol
Last updated:2023-06-08 09:03:08

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER Properties

solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 100 μg/ml

SAFETY

Risk and Safety Statements

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10140 Prostaglandin E2-1-glyceryl ester ≥98% (as a 85:15 mixture of the 1- and 2-glyceryl esters) 37497-47-5 1mg $89 2024-03-01 Buy
Cayman Chemical 10140 Prostaglandin E2-1-glyceryl ester ≥98% (as a 85:15 mixture of the 1- and 2-glyceryl esters) 37497-47-5 5mg $395 2024-03-01 Buy
Cayman Chemical 10140 Prostaglandin E2-1-glyceryl ester ≥98% (as a 85:15 mixture of the 1- and 2-glyceryl esters) 37497-47-5 10mg $700 2024-03-01 Buy
American Custom Chemicals Corporation LIP0003240 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID-2,3-DIHYDROXYPROPYL ESTER 95.00% 37497-47-5 5MG $504.54 2021-12-16 Buy
AK Scientific 1580AH 9-oxo-11alpha,15S-Dihydroxy-prosta-5Z,13E-dien-1-oicacid,2,3-dihydroxypropylester 37497-47-5 5mg $537 2021-12-16 Buy
Product number Packaging Price Buy
10140 1mg $89 Buy
10140 5mg $395 Buy
10140 10mg $700 Buy
LIP0003240 5MG $504.54 Buy
1580AH 5mg $537 Buy

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER Chemical Properties,Uses,Production

Description

2-Arachidonoyl glycerol (2-AG; ) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor.1,2 Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.3 The biosynthesis of PGH, PGD, PGE, PGF, and Thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.4

Definition

ChEBI: Prostaglandin E2 1-glyceryl ester is a 1-monoglyceride resulting from the condensation of the carboxy group of prostaglandin E2 with the 1-hydroxy group of glycerol. It has a role as a human metabolite. It is a 1-monoglyceride, an alicyclic ketone, a prostaglandins E, a tetrol and a secondary allylic alcohol. It is functionally related to a prostaglandin E2.

References

1. Sugiura, T., Kodaka, T., Kondo, S., et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma X glioma hybrid NG108-15 cells Biochem. Biophys. Res. Commun. 229,58-64(1996).
2. Sugiura, T., Kodaka, T., Kondo, S., et al. Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells J. Biochem. 122(4),890-895(1997).
3. Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides J. Biol. Chem. 277(47),44877-44885(2002).
4. Kozak, K.R., Crews, B.C., Ray, J.L., et al. Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo J. Biol. Chem. 276(40),36993-36998(2001).

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER Suppliers

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37497-47-5(9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER)Related Search:

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER PROSTAGLANDIN E2-1-GLYCERYL ESTER RJXVYMMSQBYEHN-LVXZDWGESA-N Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, 2,3-dihydroxypropyl ester, (5Z,11α,13E,15S)- 37497-47-5