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N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea structure
CAS No.
39236-46-9
Chemical Name:
N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea
Synonyms
IMIDUREA;Sept 115;germall115;Tristat 1U;Euxyl K 200;Biopure 100;Imidurea NF;Unicide U-13;Imidurea (200 mg);Imidazolidnyl UREA
CBNumber:
CB3426267
Molecular Formula:
C11H16N8O8
Formula Weight:
388.29
MOL File:
39236-46-9.mol

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea Properties

Melting point:
141-143℃
Boiling point:
514.04°C (rough estimate)
Density 
1.4245 (rough estimate)
refractive index 
1.6910 (estimate)
storage temp. 
2-8°C
solubility 
Soluble in water and in glycerol, but insoluble in almost all organic solvents.
pka
7.41±0.10(Predicted)
form 
Liquid
color 
Clear
Water Solubility 
soluble
Merck 
14,4916
Stability:
Stable.
InChIKey
ZCTXEAQXZGPWFG-UHFFFAOYSA-N
CAS DataBase Reference
39236-46-9(CAS DataBase Reference)
FDA UNII
M629807ATL
EPA Substance Registry System
Imidurea (39236-46-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H317
Precautionary statements  P264-P280i-P305+P351+P338-P337+P313-P280
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26-36
WGK Germany  2
RTECS  YT7365000
TSCA  Yes
HS Code  29332990

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich I5133 Imidazolidinyl urea 39236-46-9 25g $43.5 2021-12-16 Buy
Sigma-Aldrich 1336806 Imidurea United States Pharmacopeia (USP) Reference Standard 39236-46-9 200mg $414 2021-12-16 Buy
TCI Chemical I0665 Imidazolidinyl Urea >90.0%(N) 39236-46-9 25g $29 2021-12-16 Buy
TCI Chemical I0665 Imidazolidinyl Urea >90.0%(N) 39236-46-9 250g $165 2021-12-16 Buy
Alfa Aesar H60729 Imidazolidinyl urea 39236-46-9 100g $80.5 2021-12-16 Buy

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea Chemical Properties,Uses,Production

Description

Imidazolidinyl urea, a formaldehyde releaser, is mainly contained in cosmetics and liquid soaps.

Chemical Properties

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is solid with a mild odour

Chemical Properties

Imidurea is a white, free-flowing odorless powder.

Uses

imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.

Uses

Antimicrobial

Uses

Antimicrobial preservative in cosmetics and topical pharmaceutical preparations.

Production Methods

Imidurea is produced by the condensation of allantoin with formaldehyde.

Pharmaceutical Applications

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is a broad-spectrum antimicrobial preservative used in cosmetics and topical pharmaceutical formulations; typical concentrations used are 0.03–0.5% w/w. It is effective between pH 3–9 and is reported to have synergistic effects when used with parabens.

Contact allergens

Imidazolidinyl urea, a formaldehyde releaser related to diazolidinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with para- bens. It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps.

Safety

Imidurea is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. However, there have been some reports of contact dermatitis associated with imidurea, although these are relatively few considering its widespread use in cosmetics. Although imidurea releases formaldehyde, it does not appear to be associated with cross-sensitization with formaldehyde or other formaldehyde-releasing compounds.
LD50 (mouse, oral): 7.2 g/kg
LD50 (rabbit, skin): > 8 g/kg
LD50 (rat, oral): 11.3 g/kg

storage

Imidurea is hygroscopic and should be stored in a well-closed container in a cool, dry place.

Incompatibilities

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is incompatible with strong oxidants. It is compatible with other preservatives including sorbic acid and quaternary ammonium compounds. It is also compatible with other pharmaceutical and cosmetic excipients including proteins, nonionic surfactants, and lecithin.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical preparations). Accepted for use in cosmetics in Europe and the USA. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea Preparation Products And Raw materials

Raw materials

Preparation Products


N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea Suppliers

Global( 236)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15421 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Tianjin Zhongxin Chemtech Co., Ltd.
+8618622897568 +86-022-66880623
022-66880086 sales@tjzxchem.com China 543 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Jinan Finer Chemical Co., Ltd
+8615508631887 +86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 1735 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5917 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2514 58

View Lastest Price from N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-25 Imidazolidinyl Urea
39236-46-9
US $20.00 / KG 1KG 99% 200tons/ year Speranza Chemical Co., Ltd.
2021-12-01 Imidazolidinyl Urea
39236-46-9
US $10.00 / Kg/Drum 1KG 98% 10 ton Hebei Crovell Biotech Co Ltd
2021-11-09 Imidazolidinyl urea
39236-46-9
US $10.00 / KG 1KG 98.0% 10tons/month WUHAN FORTUNA CHEMICAL CO., LTD

39236-46-9(N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea)Related Search:


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