Ifenprodil
- CAS No.
- 23210-56-2
- Chemical Name:
- Ifenprodil
- Synonyms
- IFENPRODIL;2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propanol;4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol;2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol;2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propan-1-ol;1-(4-Hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol;4-[2-[4-(benzyl)-1-piperidyl]-1-hydroxy-propyl]phenol;4-Benzyl-α-(p-hydroxyphenyl)-β-methyl-1-piperidineethanol;4-[1-Hydroxy-2-[4-(phenylmethyl)piperidin-1-yl]propyl]phenol;2-?(4-?Benzylpiperidino)?-?1-?(1-?hydroxyphenyl)?-?1-?propanol
- CBNumber:
- CB3427239
- Molecular Formula:
- C21H27NO2
- Molecular Weight:
- 325.45
- MDL Number:
- MFCD00209873
- MOL File:
- 23210-56-2.mol
| Melting point | 114° |
|---|---|
| Boiling point | 463.62°C (rough estimate) |
| Density | 1.0825 (rough estimate) |
| refractive index | 1.5614 (estimate) |
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.99±0.26(Predicted) |
| color | White to Off-White |
| Water Solubility | Soluble to 15 mM in water with gentle warming |
| FDA UNII | R8OE3P6O5S |
| ATC code | C04AX28 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312a-P330-P501a |
| Toxicity | LD50 oral in mouse: 320mg/kg |
Ifenprodil price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J60932 | Ifenprodil hemitartrate, 99% | 23210-56-2 | 10mg | $84.65 | 2024-03-01 | Buy |
| Alfa Aesar | J60932 | Ifenprodil hemitartrate, 99% | 23210-56-2 | 50mg | $312.65 | 2024-03-01 | Buy |
| TRC | I258003 | Ifenprodil | 23210-56-2 | 100mg | $410 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0002060 | 1-METHYL-2-HYDROXY-2-(4-HYDROXYPHENYL)ETHYL-1-(4-BENZYLPIPERIDINE) 95.00% | 23210-56-2 | 10MG | $617.3 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0002060 | 1-METHYL-2-HYDROXY-2-(4-HYDROXYPHENYL)ETHYL-1-(4-BENZYLPIPERIDINE) 95.00% | 23210-56-2 | 50MG | $842.87 | 2021-12-16 | Buy |
Ifenprodil Chemical Properties,Uses,Production
Originator
Vadilex,Carriere,France,1972
Uses
vasodilator
Uses
Ifenprodil is a NMDA receptor antagonist.
Definition
ChEBI: 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol is a member of piperidines.
Manufacturing Process
The initial steps involve reacting benzyl chloride with 4-
hydroxypropiophenone. The benzyloxypropiophene thus obtained is first
brominated and then reacted with 4-benzylpiperidine to give 1-(pbenzyloxyphenyl)-2-(4-benzyl-piperidino)propan-1-one.
The neutral tartrate may be prepared directly by reduction of 1-(pbenzyloxyphenyl)-2-(4-benzyl-piperidino)propan-1-one. For the reduction, a
mixture of 175 g of ketone (0.425 mol) and 32 g of tartaric acid (0.213 mol)
is hydrogenated at 50°C under pressure of 50 kg/cm2 in 440 ml of methanol
in the presence of 12 g of palladium on charcoal.
The catalyst is filtered off at elevated temperature, and the filtrate is
concentrated by evaporation under reduced pressure to a volume of 300 ml
and added in a thin stream to 2.5 liters of diethyl ether with mechanical
agitation. The precipitate is separated, washed with diethyl ether and dried in
vacuo at 80° to 85°C for several hours. 325 g (96% yield) of the neutral
tartrate of 1-(p-hydroxyphenyl)-2-(4-benzyl-piperidino)propan-1-ol are
obtained.
Therapeutic Function
Vasodilator
Biological Activity
NMDA receptor antagonist, acting at the polyamine site. Also an α -adrenergic vasodilator. σ 2 ligand displaying about 3-fold selectivity over σ 1 sites.
Ifenprodil Preparation Products And Raw materials
Raw materials
Preparation Products
Ifenprodil Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Guangzhou Biocar Biotechnology Co.,Ltd. | +86-13397196830 | carrie@gzbiocar.cn | China | 436 | 58 |
| Wuhan EnTai Technology Development Co,.Ltd | 86-27-82330560 | 2536851935@qq.com | China | 348 | 69 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |