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2-PHENYL-1,3-INDANDIONE

2-PHENYL-1,3-INDANDIONE
2-PHENYL-1,3-INDANDIONE structure
CAS No.
83-12-5
Chemical Name:
2-PHENYL-1,3-INDANDIONE
Synonyms
PID;MTA2;Indon;Bindan;Indema;Indion;MTA1L1;Danilon;Dineval;Fenilin
CBNumber:
CB3429480
Molecular Formula:
C15H10O2
Formula Weight:
222.24
MOL File:
83-12-5.mol

2-PHENYL-1,3-INDANDIONE Properties

Melting point:
144-148 °C(lit.)
Boiling point:
243.3 °C (0.3 mmHg)
Density 
1.1404 (rough estimate)
refractive index 
1.6600 (estimate)
Flash point:
208 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Very slightly soluble in water; slightly soluble in ethanol (96%) and in ether. Solutions are yellow to red.
pka
pKa 4.09(H2O,t =25,I=0.1) (Uncertain)
Merck 
14,7234
CAS DataBase Reference
83-12-5(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
5M7Y6274ZE
NCI Dictionary of Cancer Terms
PID
ATC code
B01AA02
SAFETY
  • Risk and Safety Statements
Hazard Codes  T
Risk Statements  25-43
Safety Statements  36/37/39-45
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  NK6125000
HazardClass  6.1(b)
PackingGroup  III
NFPA 704
1
2 0

2-PHENYL-1,3-INDANDIONE price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical P1029 2-Phenyl-1,3-indandione >98.0%(GC) 83-12-5 25g $64 2021-12-16 Buy
TCI Chemical P1029 2-Phenyl-1,3-indandione >98.0%(GC) 83-12-5 250g $361 2021-12-16 Buy
Cayman Chemical 30060 Phenindione 83-12-5 50mg $94 2021-12-16 Buy
Cayman Chemical 30060 Phenindione 83-12-5 25mg $59 2021-12-16 Buy
TRC P297250 Phenindione 83-12-5 5g $150 2021-12-16 Buy

2-PHENYL-1,3-INDANDIONE Chemical Properties,Uses,Production

Description

Phenindione is an anticoagulant and vitamin K antagonist. It inhibits the reduction of vitamin K1 epoxide to vitamin K1 by vitamin K1 epoxide reductase in rat liver homogenates in a concentration-dependent manner. In vivo, phenindione (500 mg/kg) inhibits prothrombin synthesis and conversion of vitamin K1 epoxide to vitamin K1 in rats by 50 and 57%, respectively. Dietary administration of phenindione (4 mg/kg per day) inhibits aortic atherosclerosis or intracardial thrombosis in rat models of diet-induced atherosclerosis or intravascular thrombosis, respectively.

Chemical Properties

light yellow fluffy fine flakes

Uses

Oral anticoagulant (indanedione).

Uses

Like coumarin derivatives, phenindione, a compound of the indandione class, acts by altering biosynthesis of coagulant proteins in the liver. It is used for preventing and treating thrombosis, thrombophlebitis, and thromboembolism. However, because of a number of side effects such as polyurea, polydipsia, tachycardia, and others, it is rarely used in practical medicine.

brand name

Hedulin (Sanofi Aventis).

Chemical Synthesis

Phenindione, 3-phenylindan-1,3-dion (24.1.16), is synthesized in two ways. The first consists of condensating benzaldehyde with phthalide in the presence of sodium ethoxide. Evidently, the resulting phenylmethylenphthalide (24.1.15) rearranges under the reaction conditions to give the desired phenindione (24.1.16). The second method consists of condensation of phenylacetic acid with phthalic anhydride, forming phenylmethylenphthalide (24.1.15), which rearranges further in the presence of sodium ethoxide to phenindione.

Purification Methods

Crystallise the dione from EtOH (m 156o) or CHCl3 (m 148-150o). [Beilstein 7 H 808, 7 III 4100, 7 IV 2570.]

2-PHENYL-1,3-INDANDIONE Preparation Products And Raw materials

Raw materials

Preparation Products


2-PHENYL-1,3-INDANDIONE Suppliers

Global( 82)Suppliers
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Casorganics US Corp
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BOC Sciences
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Target Molecule Corp
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Dideu Industries Group Limited
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Wuhan wingroup Pharmaceutical Co., Ltd
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Mainchem Co., Ltd. +86-0592-6210733
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J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
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TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24555 81
Energy Chemical 400-005-6266 021-58432009-
021-58436166 sales8178@energy-chemical.com China 43431 61
LGM Pharma 1-(800)-881-8210
615-250-9817 inquiries@lgmpharma.com United States 1938 70

View Lastest Price from 2-PHENYL-1,3-INDANDIONE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-08 2-PHENYL-1,3-INDANDIONE
83-12-5
US $5.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd

2-PHENYL-1,3-INDANDIONE Spectrum


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