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1-Benzofuran-5-carbaldehyde

1-Benzofuran-5-carbaldehyde structure

CAS No.: 10035-16-2

Chemical Name:: 1-Benzofuran-5-carbaldehyde

Synonyms: 5-Formylbenzofuran;5-FORMYLBENZO(B)FURAN;5-Formyl-1-benzofuran;Benzofurancarbaldehyde;5-Benzofurancarbaldehyde;5-FORMYLBENZO[BETA]FURAN;Benzofuran-5-carbaldehyde;5-Benzofurancarboxaldehyde;1-BENZOFURAN-5-CARBALDEHYDE;Benzofuran-5-carboxaldehyde

CBNumber:: CB3437146

Molecular Formula:: C9H6O2

Molecular Weight:: 146.14

MDL Number:: MFCD03411182

MOL File:: 10035-16-2.mol

Last updated:2025-07-24 18:13:42

Product description	Number	Pack Size	Price
1-Benzofuran-5-carbaldehyde	B203670	1g	$130
1-Benzofuran-5-carbaldehyde	FB10743	100mg	$50
1-Benzofuran-5-carbaldehyde	FB10743	1g	$200
Benzo[b]furan-5-carboxaldehyde 97%	OR10877	100mg	$21
1-Benzofuran-5-carbaldehyde	FB10743	250mg	$80
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1-Benzofuran-5-carbaldehyde Properties

Melting point	50.5
Boiling point	70-74°C 0,15mm
Density	1.238±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	low melting solid
color	Light yellow crystalline
InChI	InChI=1S/C9H6O2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-6H
InChIKey	LLLBDLDNTMMZHL-UHFFFAOYSA-N
SMILES	O1C2=CC=C(C=O)C=C2C=C1
CAS DataBase Reference	10035-16-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS08
Signal word	Danger
Hazard statements	H314-H341-H290
Precautionary statements	P501-P260-P202-P234-P201-P264-P280-P390-P308+P313-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37/39-37/39
HazardClass	IRRITANT
HS Code	2932990090

1-Benzofuran-5-carbaldehyde price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B203670	1-Benzofuran-5-carbaldehyde	10035-16-2	1g	$130	2021-12-16	Buy
Biosynth Carbosynth	FB10743	1-Benzofuran-5-carbaldehyde	10035-16-2	100mg	$50	2021-12-16	Buy
Biosynth Carbosynth	FB10743	1-Benzofuran-5-carbaldehyde	10035-16-2	1g	$200	2021-12-16	Buy
Apolloscientific	OR10877	Benzo[b]furan-5-carboxaldehyde 97%	10035-16-2	100mg	$21	2021-12-16	Buy
Biosynth Carbosynth	FB10743	1-Benzofuran-5-carbaldehyde	10035-16-2	250mg	$80	2021-12-16	Buy

Product number	Packaging	Price	Buy
B203670	1g	$130	Buy
FB10743	100mg	$50	Buy
FB10743	1g	$200	Buy
OR10877	100mg	$21	Buy
FB10743	250mg	$80	Buy

1-Benzofuran-5-carbaldehyde Chemical Properties,Uses,Production

Chemical Properties

Colorless to light yellow liqui

Uses

1-Benzofuran-5-carbaldehyde is a building block used as a reactant in the synthetic preparation of benzofuranyl oxadiazoles as inhibitors of glycogen synthase kinase-3β with good brain permeability. It is also used in the synthesis of pyrroloquinolone PDE5 inhibitors used for clinical studies on erectile dysfunction.

Synthesis

55745-70-5

10035-16-2

General procedure for the synthesis of benzofuran-5-carbaldehyde from 2,3-dihydrobenzofuran-5-carbaldehyde: N-bromosuccinimide (NBS, 0.656 g, 3.69 mmol) and azobisisobutyronitrile (AIBN, 8.10 mg, 49.2 μmol) were added to a solution of chlorobenzene (7.3 mL) at room temperature and under argon protection to 2,3-dihydrobenzofuran-5-carbaldehyde (0.364 g, 2.46 mmol) in a solution of chlorobenzene (7.3 mL). The reaction mixture was stirred at 80 °C for 1 h before being cooled to room temperature and diluted with ethyl acetate (EtOAc). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine, dried over anhydrous sodium sulfate (Na2SO4) and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 3:97) to afford benzofuran-5-carbaldehyde (0.268 g, 1.84 mmol, 75% yield) as a colorless oil. Its 1H-NMR (CDCl3, 400 MHz) data were as follows: δ 6.82 (d, J = 2.0 Hz, 1H, furan-H), 7.54 (d, J = 8.8 Hz, 1H, Ar-H), 7.65 (d, J = 2.0 Hz, 1H, furan-H), 7.79 (d, J = 8.8 Hz, 1H, Ar-H), 8.07 (s 1H, Ar-H), 9.99 (s, 1H, -CHO). The spectral data of the obtained compounds are in agreement with literature reports (van Otterlo et al., 2005).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 20, p. 6270 - 6286
[2] Phytochemistry, 2013, vol. 96, p. 132 - 147
[3] Patent: US2014/309427, 2014, A1. Location in patent: Paragraph 0074; 0075; 0076; 0077
[4] Patent: WO2018/64135, 2018, A1. Location in patent: Paragraph 0174-0177

1-Benzofuran-5-carbaldehyde Preparation Products And Raw materials

Raw materials

Sulfur Sodium hydride p-Toluenesulfonic acid Acetonitrile Nitrogen

tert-Butyllithium N-Bromosuccinimide Ethanol N,N-Dimethylformamide Sodium chloride

Bromoacetaldehyde diethyl acetal Potassium carbonate Phosphorus oxitrichloride 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Carbon tetrachloride

2,3-Dihydrobenzofuran Polyphosphoric acid Diethyl ether Benzene Ammonium chloride

4-Bromophenol Ethyl acetate Hydrochloric acid Sodium bicarbonate Sodium hydroxide

Magnesium sulfate PETROLEUM ETHER n-Butyllithium

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Preparation Products

1-Benzofuran-5-carbaldehyde Suppliers

Global( 170)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21612	55
Speranza Chemical Co., Ltd.	+86-86-075521030354 +8618688942810	sophieliu@speranzachem.com	China	925	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29846	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8830	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	11767	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Speranza Chemical Co., Ltd.	55
career henan chemical co	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Zhengzhou Alfa Chemical Co.,Ltd	58

View Lastest Price from 1-Benzofuran-5-carbaldehyde manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2023-03-21	1-Benzofuran-5-carbaldehyde 10035-16-2	US $0.00 / kg	1kg	98.0%min	100kg	LY Global chemicals co.,ltd .
	2019-07-06	1-Benzofuran-5-carbaldehyde 10035-16-2	US $8.00 / kg	1kg	99%	10MT	Career Henan Chemical Co

1-Benzofuran-5-carbaldehyde
10035-16-2
US $0.00 / kg
98.0%min
LY Global chemicals co.,ltd .

1-Benzofuran-5-carbaldehyde
10035-16-2
US $8.00 / kg
99%
Career Henan Chemical Co

1-Benzofuran-5-carbaldehyde Spectrum

1-Benzofuran-5-carbaldehyde(10035-16-2)¹HNMR

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KHELLINONE 2,3-DIHYDRO-1-BENZOFURAN-7-CARBALDEHYDE 2,2-DIMETHYL-2,3-DIHYDRO-1-BENZOFURAN-7-CARBALDEHYDE

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1-BENZOFURAN-5-CARBALDEHYDE 5-FORMYLBENZO[BETA]FURAN 5-FORMYLBENZO(B)FURAN 5-Formylbenzofuran Benzofuran-5-carboxaldehyde Benzofurancarbaldehyde Benzo[b]furan-5-carboxaldehyde 96% 5-Formylbenzo[beta]furan, min. 96 % Benzo[b]furan-5-carboxaldehyde 5-Benzofurancarbaldehyde Benzofuran-5-carbaldehyde 1-Benzofuran-5-carbaldehyde ,97% 5-Formyl-1-benzofuran 5-Benzofurancarboxaldehyde 5-Formyl-1-benzofuran, 5-Formylbenzo[b]furan, 1-Benzofuran-5-carboxaldehyde 10035-16-2 API intermediates Furan&Benzofuran