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Acetamide

Acetamide
Acetamide
CAS No.
60-35-5
Chemical Name:
Acetamide
Synonyms
AMIDE C2;Acetamid;CH3CONH2;Actamide;ACETAMIDE;ETHANAMIDE;NCI-C02108;Acetylamide;acetylamine;Acetamide,99%
CBNumber:
CB3453432
Molecular Formula:
C2H5NO
Formula Weight:
59.07
MOL File:
60-35-5.mol

Acetamide Properties

Melting point:
78-80 °C(lit.)
Boiling point:
221 °C(lit.)
Density 
1.159
vapor pressure 
1 mm Hg ( 65 °C)
refractive index 
1.4274
FEMA 
4251
Flash point:
220-222°C
storage temp. 
Store at RT
solubility 
H2O: 0.5 g/mL, Hazen ≤50
pka
0.63(at 25℃)
form 
Crystals
color 
White
Water Solubility 
2000 g/L (20 ºC)
Merck 
14,43
BRN 
1071207
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents, strong bases. Deliquescent. Triboluminescent.
CAS DataBase Reference
60-35-5(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide(60-35-5)
EPA Substance Registry System
Acetamide(60-35-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  40
Safety Statements  36/37
RIDADR  UN 3077 9/PG 3
WGK Germany  1
RTECS  AB4025000
3
TSCA  Yes
HS Code  29241900
Hazardous Substances Data 60-35-5(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Acetamide price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 00160 Acetamide ≥99.0% (GC) 60-35-5 50g $25 2018-11-13 Buy
Sigma-Aldrich 00160 Acetamide ≥99.0% (GC) 60-35-5 1kg $165 2018-11-13 Buy
TCI Chemical A0007 Acetamide >98.0%(GC) 60-35-5 25g $21 2017-11-08 Buy
TCI Chemical A0007 Acetamide >98.0%(GC) 60-35-5 500g $90 2017-11-08 Buy
Alfa Aesar A12589 Acetamide, 99% 60-35-5 1000g $88.3 2018-11-13 Buy

Acetamide Chemical Properties,Uses,Production

Description

Acetamide (MEA or ethanamide),  the amide of acetic acid, is a white crystalline solid in pure form with a mousy odor. Low toxicity. It is produced by dehydrating ammonium acetate. Acetamide is found in red beetroot.
Acetamide is used primarily as a solvent, plasticizer, and a wetting and penetrating agent. it was used as an intermediate in the synthesis of methylamine, thioacetamide, hypnotics, insecticides, medicinals and various plastics, a soldering flux ingredient, a wetting agent and penetration accelerator for dyes, and as a plasticizer in leather, cloth and coatings.
ethanolamine is an amide made from acetamide and monoethanolamine. It is a clear liquid. In cosmetics and personal care products, It is used in the formulation of bubble baths, hair conditioners, shampoos, wave sets, moisturizers, and other bath and hair care products.It increases the water content of the top layers of the skin by drawing moisture from the surrounding air. It also enhances the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.

Chemical Properties

Acetamide occurs as hexagonal colourless deliquescent crystals with a musty odour. It is incompatible with strong acids, strong oxidising agents, strong bases, and triboluminescent materials. Acetamide is used primarily as a solvent, a plasticiser, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastic and chemical industries.

Uses

  1. Acetamide is often used as plasticizer and as industrial solvent.
  2. molten acetamide is an excellent solvent for many organic and inorganic compounds.
  3. Solubilizer.
  4. renders sparingly soluble substances more soluble in water by mere addition or by fusion.
  5. stabilizer.
  6. manufacture of methylamine, denaturing alcohol.
  7. In organic syntheses.
  8. Acetamide is used as a co-monomer in the production of polymeric materials such as polyvinyl acetamide, a polymeric product used as an absorbent.
  9. It can be used for the transamidation of carbxamides in 1,4-dioxane in the absence of a catalyst.

General Description

Colorless crystals with a mousy odor (NTP, 1999). Low toxicity.

Air & Water Reactions

Deliquescent. Very soluble in water.

Reactivity Profile

Acetamide may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).

Fire Hazard

The flash point of Acetamide has not been determined, but Acetamide is probably combustible.

Purification Methods

Acetamide is crystallised by dissolving in hot MeOH (0.8mL/g), diluting with Et2O and allowing to stand [Wagner J Chem Edu 7 1135 1930]. Alternate crystallisation solvents are acetone, *benzene, chloroform, dioxane, methyl acetate or *benzene/ethyl acetate mixtures (3:1 and 1:1). It has also been recrystallised from hot water after treating with HCl-washed activated charcoal (which had been repeatedly washed with water until free from chloride ions), then crystallised again from hot 50% aqueous EtOH and finally twice from hot 95% EtOH [Christoffers & Kegeles J Am Chem Soc 85 2562 1963]. Finally it is dried in a vacuum desiccator over P2O5. Acetamide is also purified by distillation (b 221-223o) or by sublimation in vacuo. It has also been purified by two recrystallisations from cyclohexane containing 5% (v/v) of *benzene. Needle-like crystals separate and are filtered, washed with a small volume of distilled H2O and dried with a flow of dry N2. [Slebocka-Tilk et al. J Am Chem Soc 109 4620 1987, Beilstein 2 H 175, 2 I 80, 2 II 177, 2 III 384, 2 IV 399.]

Acetamide Preparation Products And Raw materials

Raw materials

Preparation Products


Acetamide Suppliers

Global( 237)Suppliers
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