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Acetamide

Acetamide
Acetamide structure
CAS No.
60-35-5
Chemical Name:
Acetamide
Synonyms
CH3CONH2;AMIDE C2;Acetamid;Actamide;ACETAMIDE;NCI-C02108;ETHANAMIDE;acetylamine;Acetylamide;Acetamide,99%
CBNumber:
CB3453432
Molecular Formula:
C2H5NO
Formula Weight:
59.07
MOL File:
60-35-5.mol

Acetamide Properties

Melting point:
78-80 °C(lit.)
Boiling point:
221 °C(lit.)
Density 
1.159
vapor pressure 
1 mm Hg ( 65 °C)
refractive index 
1.4274
Flash point:
220-222°C
storage temp. 
Store at RT
solubility 
H2O: 0.5 g/mL, Hazen ≤50
pka
0.63(at 25℃)
form 
Crystals
color 
White
Water Solubility 
2000 g/L (20 ºC)
Merck 
14,43
JECFA Number
1592
BRN 
1071207
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents, strong bases. Deliquescent. Triboluminescent.
InChIKey
DLFVBJFMPXGRIB-UHFFFAOYSA-N
CAS DataBase Reference
60-35-5(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide(60-35-5)
EPA Substance Registry System
Acetamide(60-35-5)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  40
Safety Statements  36/37
RIDADR  UN 3077 9/PG 3
WGK Germany  1
RTECS  AB4025000
3
TSCA  Yes
HS Code  29241900
Hazardous Substances Data 60-35-5(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 7000 mg/kg
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.
P501 Dispose of contents/container to..…

Acetamide price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 00160 Acetamide ≥99.0% (GC) 60-35-5 50g $25 2018-11-13 Buy
Sigma-Aldrich 00160 Acetamide ≥99.0% (GC) 60-35-5 1kg $165 2018-11-13 Buy
TCI Chemical A0007 Acetamide >98.0%(GC) 60-35-5 25g $29 2018-11-22 Buy
TCI Chemical A0007 Acetamide >98.0%(GC) 60-35-5 500g $123 2018-11-22 Buy
Alfa Aesar A12589 Acetamide, 99% 60-35-5 1000g $88.3 2018-11-13 Buy

Acetamide Chemical Properties,Uses,Production

Description

Acetamide (MEA or ethanamide),  the amide of acetic acid, is a white crystalline solid in pure form with a mousy odor. Low toxicity. It is produced by dehydrating ammonium acetate. Acetamide is found in red beetroot.
Acetamide is used primarily as a solvent, plasticizer, and a wetting and penetrating agent. it was used as an intermediate in the synthesis of methylamine, thioacetamide, hypnotics, insecticides, medicinals and various plastics, a soldering flux ingredient, a wetting agent and penetration accelerator for dyes, and as a plasticizer in leather, cloth and coatings.
ethanolamine is an amide made from acetamide and monoethanolamine. It is a clear liquid. In cosmetics and personal care products, It is used in the formulation of bubble baths, hair conditioners, shampoos, wave sets, moisturizers, and other bath and hair care products.It increases the water content of the top layers of the skin by drawing moisture from the surrounding air. It also enhances the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.

Chemical Properties

Acetamide occurs as hexagonal colourless deliquescent crystals with a musty odour. It is incompatible with strong acids, strong oxidising agents, strong bases, and triboluminescent materials. Acetamide is used primarily as a solvent, a plasticiser, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastic and chemical industries.

Chemical Properties

Acetamide occurs as hexagonal, colorless deliquescent crystals with a musty odor. It is incompatible with strong acids, strong oxidizing agents, strong bases, and tribolumi- nescent. Acetamide is used primarily as a solvent, as a plasticizer, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastics and chemical industries.

Chemical Properties

Acetamide is a colorless to yellow, deliquescent, crystalline solid. Odorless if pure, “mousy” odor if impure. Odor threshold5140 160 milligram per cubic meter.

Uses

  1. Acetamide is often used as plasticizer and as industrial solvent.
  2. molten acetamide is an excellent solvent for many organic and inorganic compounds.
  3. Solubilizer.
  4. renders sparingly soluble substances more soluble in water by mere addition or by fusion.
  5. stabilizer.
  6. manufacture of methylamine, denaturing alcohol.
  7. In organic syntheses.
  8. Acetamide is used as a co-monomer in the production of polymeric materials such as polyvinyl acetamide, a polymeric product used as an absorbent.
  9. It can be used for the transamidation of carbxamides in 1,4-dioxane in the absence of a catalyst.

General Description

Colorless crystals with a mousy odor (NTP, 1999). Low toxicity.

Air & Water Reactions

Deliquescent. Very soluble in water.

Reactivity Profile

Acetamide may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).

Health Hazard

After oral exposures to acetamide, animals developed liver tumors. However, no informa- tion is available on the carcinogenic effects of acetamide in humans. The US EPA has not classifi ed acetamide for carcinogenicity. The IARC has classifi ed acetamide as a Group 2B, meaning a possible human carcinogen.

Health Hazard

Mild irritant; acute oral toxicity in animals very low; oral LD50 value (rats):7000 mg/kg; carcinogenic to animals; oraladministration caused blood and liver tumorsin mice and rats; carcinogenicity: animal limited evidence, no evidence in humans.

Fire Hazard

The flash point of Acetamide has not been determined, but Acetamide is probably combustible.

Safety Profile

Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by intraperitoneal and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also AMIDES. When heated to decomposition it emits toxic fumes of NOx,.

Potential Exposure

Used as a stabilizer, plasticizer, wetting agent; solvent in plastics, lacquers, explosive; soldering flux ingredient; and chemical manufacturing

First aid

If this chemical gets into the eyes, remove any contact lenses at once, and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. If this chemical has been inhaled, remove from exposure and transfer promptly to a medical facility.

storage

Acetamide should be kept stored in a tightly closed container, in a cool, dry, ventilated area. It should be protected against physical damage, away from any source of heat, ignition, or oxidizing materials.

Shipping

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Purification Methods

Acetamide is crystallised by dissolving in hot MeOH (0.8mL/g), diluting with Et2O and allowing to stand [Wagner J Chem Edu 7 1135 1930]. Alternate crystallisation solvents are acetone, *benzene, chloroform, dioxane, methyl acetate or *benzene/ethyl acetate mixtures (3:1 and 1:1). It has also been recrystallised from hot water after treating with HCl-washed activated charcoal (which had been repeatedly washed with water until free from chloride ions), then crystallised again from hot 50% aqueous EtOH and finally twice from hot 95% EtOH [Christoffers & Kegeles J Am Chem Soc 85 2562 1963]. Finally it is dried in a vacuum desiccator over P2O5. Acetamide is also purified by distillation (b 221-223o) or by sublimation in vacuo. It has also been purified by two recrystallisations from cyclohexane containing 5% (v/v) of *benzene. Needle-like crystals separate and are filtered, washed with a small volume of distilled H2O and dried with a flow of dry N2. [Slebocka-Tilk et al. J Am Chem Soc 109 4620 1987, Beilstein 2 H 175, 2 I 80, 2 II 177, 2 III 384, 2 IV 399.]

Incompatibilities

Reacts with strong acids, such as hydrochloric, sulfuric, and nitric, strong oxidizers; strong bases; strong reducing agents such as hydrides; ammoniaisocyanates, phenols, cresols. Contact with water causes slow hydrolyzation to ammonia and acetate salts.

Waste Disposal

Add to alcohol or benzene as a flammable solvent and incinerate; oxides of nitrogen produced may be scrubbed out with alkaline solution. All federal, state, and local environmental regulations must be observed.

Precautions

During handling and/use of acetamide, workers should wear special protective equipment. After leaving work areas, workers should wash hands, face, forearms, and neck, dispose of outer clothing, and change to clean garments at the end of the day.

Acetamide Preparation Products And Raw materials

Raw materials

Preparation Products


Acetamide Suppliers

Global( 260)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 407 50
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21967 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1367 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 24001 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20095 58
Hebei Jimi Trading Co., Ltd.
+86 017772612259 +86 319 5273535
admin@hebeijimi.com CHINA 309 58

View Lastest Price from Acetamide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-04-04 Acetamide
60-35-5
US $100.00 / kg 100g 99.8% 10tons Hebei Jimi Trading Co., Ltd.
2018-12-17 Acetamide
60-35-5
US $2.00 / kg 10kg ask ask career henan chemical co

Acetamide Spectrum


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