Endosidin 2
- CAS No.
- 1839524-44-5
- Chemical Name:
- Endosidin 2
- Synonyms
- Endosidin 2;Endosidin-2 (ES-2);3-fluoro-benzoicacid,(2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide;Benzoic acid, 3-fluoro-, (2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide
- CBNumber:
- CB34666449
- Molecular Formula:
- C15H12FIN2O3
- Molecular Weight:
- 414.17
- MDL Number:
- MOL File:
- 1839524-44-5.mol
| Density | 1.67±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (greater than 40 mg/ml), in DMF (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml) |
| form | powder |
| pka | 7.75±0.36(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
Endosidin 2 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1681 | Endosidin2 ≥98% (HPLC) | 1839524-44-5 | 5MG | $105 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1681 | Endosidin2 ≥98% (HPLC) | 1839524-44-5 | 25MG | $424 | 2023-06-20 | Buy |
| Cayman Chemical | 21888 | Endosidin 2 ≥98% | 1839524-44-5 | 5mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 21888 | Endosidin 2 ≥98% | 1839524-44-5 | 10mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 21888 | Endosidin 2 ≥98% | 1839524-44-5 | 25mg | $254 | 2024-03-01 | Buy |
Endosidin 2 Chemical Properties,Uses,Production
Description
Endosidin-2 (1839524-44-5) binds to the EXO70 subunit of the exocyst complex which results in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. EXO70 is a component of the octameric exocyst complex which tethers post-Golgi vesicles to the plasma membrane before SNARE- mediated membrane fusion.2?Endosidin-2 was previously identified as a plant endomembrane trafficking disruptor.3?Inhibits intracellular glucose transporter, GLUT4 trafficking to the membrane and impairs glucose uptake in response to insulin.4?It is a valuable new tool for the study of exocytosis.
Uses
Endosidin 2 binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. A valuable tool for exocytosis studies.
Biochem/physiol Actions
Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex (Kd?= 253 μM for interaction with EXO70A1) and reduces exocytosis and endosomal recycling in plant and mammalian cells. Displays good aqueous stability. Endosidin2 has shown to disrupt the trafficking of proteins between the plasma membrane and endosome, which leads to enhanced trafficking to the vacuole for degradation. It is reported to inhibit the recycling of endocytosed transferrin to plasma membrane in HeLa cells, and can target multiple isoforms of EXO70 in mammals, resulting in misregulation of exocytosis.
References
1) Zhang?et al. (2016),?Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis;? Proc. Natl. Acad. Sci. USA,?113?E41 2) Novick?et al. (1980),?Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway;? Cell,?21?205 3) Drakakaki?et al. (2011),?Clusters of bioactive compounds target dynamic endomembrane networks in vivo;? Proc. Natl. Acad. Sci. USA,?108?17850 4) Fujimoto?et al.?(2019),?The Exocyst Complex Regulates Insulin-Stimulated Glucose Uptake of Skeletal Muscle Cells; Am. J. Physiol. Endocrinol. Metab.?317(6)?E957
Endosidin 2 Preparation Products And Raw materials
Raw materials
Preparation Products
Endosidin 2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Shaoguan Qicheng Biotechnology Co., Ltd | 18122215013 | 780229652@qq.com | China | 929 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 | sales@tybiochem.com | China | 4257 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Yantai Lianhua Technology Co., Ltd | 15552437730 | 1701654643@qq.com | China | 11400 | 58 |