Anti-Gravin antibody, Mouse monoclonal
- CAS No.
- Chemical Name:
- Anti-Gravin antibody, Mouse monoclonal
- Synonyms
- Anti-Gravin antibody, Mouse monoclonal
- CBNumber:
- CB34669273
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-Gravin antibody, Mouse monoclonal price More Price(1)
Anti-Gravin antibody, Mouse monoclonal Chemical Properties,Uses,Production
Uses
Anti-Gravin antibody has been used in western blotting immunofluorescence.
General Description
Monoclonal Anti-Gravin (mouse IgG2a isotype) is derived from the hybridoma JP74 produced by the fusion of mouse myeloma cells (X63Ag8.653) and splenocytes from BALB/c mice immunized with fractionated membrane cortex proteins from human neurons [cell lines NT2-N and SK-N-BE(2)]. Gravin protein is a myristoylated high molecular weight cytoplasmic protein expressed in endothelial cells, cultured fibroblasts and osteosarcoma cells and highly expressed in the brain.
Biochem/physiol Actions
Gravin (or AKAP12) is a scaffolding kinase that functions as a tumor suppressor. This kinase interacts with PKC, PKA and other cell cycle signaling proteins to modulate cell division, growth, differentiation and inflammatory responses. The expression of gravin isoforms (α, β, and γ) is regulated by tissue-specific promoters. Gravin also acts as an autoantigen in myasthenia gravis patients .
Anti-Gravin antibody, Mouse monoclonal Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-Gravin antibody, Mouse monoclonal Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |