ChemicalBook >> CAS DataBase List >>IDRA 21
IDRA 21
- CAS No.
- 22503-72-6
- Chemical Name:
- IDRA 21
- Synonyms
- AMPAKINE;IDRA 21;IDRA 21,98%;S-18986 IDRA-21 AMPAKINE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE;7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE;7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;IDRA 21 Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide
- CBNumber:
- CB3468324
- Molecular Formula:
- C8H9ClN2O2S
- Molecular Weight:
- 232.69
- MDL Number:
- MFCD00270874
- MOL File:
- 22503-72-6.mol
- MSDS File:
- SDS
Last updated:2024-04-01 18:08:31
| Melting point | 209 °C(Solv: acetic acid (64-19-7)) |
|---|---|
| Boiling point | 405.1±55.0 °C(Predicted) |
| Density | 1.394±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | Solid |
| pka | 9.78±0.40(Predicted) |
| color | Off-White to Pale Yellow |
| InChIKey | VZRNTCHTJRLTMU-UHFFFAOYSA-N |
| FDA UNII | 689UW7PT68 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
IDRA 21 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I5773 | IDRA 21 ≥98% | 22503-72-6 | 5mg | $210 | 2024-03-01 | Buy |
| Tocris | 1219 | IDRA 21 ≥98%(HPLC) | 22503-72-6 | 10 | $183 | 2021-12-16 | Buy |
| Tocris | 1219 | IDRA 21 ≥98%(HPLC) | 22503-72-6 | 50 | $770 | 2021-12-16 | Buy |
| Usbiological | 255490 | IDRA 21 | 22503-72-6 | 10mg | $423 | 2021-12-16 | Buy |
| TRC | I232500 | IDRA 21 | 22503-72-6 | 250mg | $1540 | 2021-12-16 | Buy |
IDRA 21 Chemical Properties,Uses,Production
Chemical Properties
white to off-white crystalline powder
Uses
IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.
Uses
IDRA-21 inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. IDRA-21 is more able to cross the blood-brain barrier than Cyclothiazide (C988960).
Definition
ChEBI: 7-chloro-3-methyl-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine 1,1-dioxide is a benzothiadiazine.
Biological Activity
Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).
storage
Room temperature
Synthesis of IDRA 21 from Hydrochlorothiazide Related Compound (N'-(2-Acetyl-sulfamoyl-4-chloro-phenyl) Acetamide)
IDRA 21 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 142)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Langyou International Trading Co., Ltd | +8618874586545 | linda@xrdchem.cn | China | 197 | 58 |
| Wuhan Qiami Technology Co., Ltd | +8618062705058 | qiamichem@163.com | China | 148 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +86-88660901 +86-18112526015 | sales@runyanpharma.com | China | 326 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 | sales@chembj.net | China | 269 | 58 |
| Hubei Chuyan Biopharmaceutical Co., Ltd | +1-027-87896938 +15172028168 | chuyan@chuyan.co | China | 24 | 58 |
| Shanghai Affida new material science and technology center | +undefined15081010295 | 2691956269@qq.com | China | 359 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
View Lastest Price from IDRA 21 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-26 | IDRA 21
22503-72-6
|
US $12.00-10.00 / Grams | 50Grams | 99.99% | 100Tons | Hebei Dangtong Import and export Co LTD | |
 |
2024-04-24 | IDRA 21
22503-72-6
|
US $0.00-0.00 / kg | 1kg | 99% | 500 | Wuhan Haorong Biotechnology Co.,Ltd | |
 |
2024-04-02 | IDRA 21
22503-72-6
|
US $10.00 / kg | 1kg | 99% | 1 Tons | Hubei Chuyan Biopharmaceutical Co., Ltd |
22503-72-6(IDRA 21)Related Search:
IDRA 21
7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE
7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE
7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE
IDRA 21,98%
7-chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide
7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-Methyl-, 1,1-dioxide
IDRA 21,7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide
7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...
IDRA 21
Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide
AMPAKINE
S-18986 IDRA-21 AMPAKINE
22503-72-6
Ligand-Gated Ion Channels
Ion Channels
Ionotropic Glutamate Receptor Modulators
Cell Signaling and Neuroscience
Cell Biology
BioChemical
API