4-Fluorobenzyl bromide
- CAS No.
- 459-46-1
- Chemical Name:
- 4-Fluorobenzyl bromide
- Synonyms
- 1-(BROMOMETHYL)-4-FLUOROBENZENE;Of fluoride broMide;4-Fluorobenzyl bromi;4-FLUOROBENZYL BROMIDE;P-FLUOROBENZYL BROMIDE;α-BroMo-p-fluorotoluene;α-Bromo-4-fluorotoluene;1-bromo-3-fluorotoluene;à-bromo-4-fluorotoluene;4-FLUOROBBENZYL BROMIDE
- CBNumber:
- CB3471414
- Molecular Formula:
- C7H6BrF
- Molecular Weight:
- 189.02
- MDL Number:
- MFCD00000359
- MOL File:
- 459-46-1.mol
- MSDS File:
- SDS
Boiling point | 85 °C15 mm Hg(lit.) |
---|---|
Density | 1.517 g/mL at 25 °C(lit.) |
refractive index |
n |
Flash point | >230 °F |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | soluble in Chloroform |
form | Liquid |
Specific Gravity | 1.517 |
color | Clear colorless to yellow |
Sensitive | Lachrymatory |
BRN | 636507 |
InChIKey | NVNPLEPBDPJYRZ-UHFFFAOYSA-N |
CAS DataBase Reference | 459-46-1(CAS DataBase Reference) |
FDA UNII | GKL3GW5GWH |
NIST Chemistry Reference | «alpha»-Bromo-4-fluorotoluene(459-46-1) |
EPA Substance Registry System | 4-Fluorobenzyl bromide (459-46-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05 |
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Signal word | Danger | |||||||||
Hazard statements | H314 | |||||||||
Precautionary statements | P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405 | |||||||||
Hazard Codes | C | |||||||||
Risk Statements | 34-36 | |||||||||
Safety Statements | 26-36/37/39-45 | |||||||||
RIDADR | UN 3265 8/PG 2 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Corrosive/Lachrymatory | |||||||||
TSCA | Yes | |||||||||
HazardClass | 8 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29039990 | |||||||||
NFPA 704 |
|
4-Fluorobenzyl bromide price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 209538 | 4-Fluorobenzyl bromide 97% | 459-46-1 | 5g | $41.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 209538 | 4-Fluorobenzyl bromide 97% | 459-46-1 | 25g | $111 | 2024-03-01 | Buy |
TCI Chemical | F0214 | 4-Fluorobenzyl Bromide >97.0%(GC) | 459-46-1 | 5g | $32 | 2024-03-01 | Buy |
TCI Chemical | F0214 | 4-Fluorobenzyl Bromide >97.0%(GC) | 459-46-1 | 25g | $90 | 2024-03-01 | Buy |
Alfa Aesar | A10208 | 4-Fluorobenzyl bromide, 97% | 459-46-1 | 10g | $45.65 | 2024-03-01 | Buy |
4-Fluorobenzyl bromide Chemical Properties,Uses,Production
Chemical Properties
4-Fluorobenzyl bromide (C7H6BrF, CAS registry No. 459-46-1) is a colorless to light yellow liquid. Its flash point is 74.8 oC. It is stable at room temperature in closed containers under normal storage and handling conditions. 1,3-Difluorobenzene can react with water to form toxic fumes. Therefore, it should be stored in a tightly closed container and should be stored in a cool, dry and well-ventilated area away from incompatible substances.
Uses
4-Fluorobenzyl bromide is an important intermediate in organic chemistry. 4-Fluorobenzyl bromide can be used as alkylating reagent to participate in the alkylation reaction with sulfamic esters (R-O-SO2-NH2) in liquid-liquid phase transfer conditions, resulting in the preparation of the N-dialkyled products or the corresponding ethers by scission of the O-SO2 bond, depending on the nature of R.
4-Fluorobenzyl bromide can be used for the synthesis of glycyrrhetinic acid (GA) derivatives, which are slow-binding inhibitors of tyrosinase and have inhibitory effects on melanogenesis.
Chemical Properties
Colorless to light yellow liqui
Uses
4-Fluorobenzyl bromide was used in the preparation of:
- 3-acetyl-1-(4-fluorobenzyl)-4-hydroxy-1H-indole
- 1-(4-fluorobenzyl)-5-(pyrrolidine-1-sulfonyl)isatin
- (S)-1-(4-fluorobenzyl)-5-(2-(4-fluorophenoxymethyl)pyrrolidine-1-sulfonyl)isatin
- 8-bromo 9-(4-fluorobenzyl) adenine
- 8-bromo 3-(4-fluorobenzyl) adenine
Uses
4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.
4-Fluorobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 811 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10248 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
View Lastest Price from 4-Fluorobenzyl bromide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-25 | 4-Fluorobenzyl Bromide
459-46-1
|
US $100.00-30.00 / kg | 1kg | 99.93% | 1000kg per week | Ouhuang Engineering Materials (Hubei) Co., Ltd | ||
2023-12-26 | 4-Fluorobenzyl bromide
459-46-1
|
US $100.00-1.00 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2023-07-28 | 4-Fluorobenzyl Bromide
459-46-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
- 4-Fluorobenzyl Bromide
459-46-1
- US $100.00-30.00 / kg
- 99.93%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
- 4-Fluorobenzyl bromide
459-46-1
- US $100.00-1.00 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
- 4-Fluorobenzyl Bromide
459-46-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd