ChemicalBook >> CAS DataBase List >>LOXO-292
LOXO-292
- CAS No.
- 2152628-33-4
- Chemical Name:
- LOXO-292
- Synonyms
- SELPERCATINIB;LOX-292;CPD2206;LOX0292;LOXO-292;ARRY-192);Serpatinib;LOXO-292 USP/EP/BP;Inhibitor LOXO-292;LOXO-292,Selpercatinib
- CBNumber:
- CB34805442
- Molecular Formula:
- C29H31N7O3
- Molecular Weight:
- 525.6
- MDL Number:
- MFCD31814089
- MOL File:
- 2152628-33-4.mol
Last updated:2024-03-18 11:47:05
| Density | 1.36±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);38.05(Max Conc. mM) |
| form | A crystalline solid |
| pka | 14.00±0.29(Predicted) |
| InChIKey | XIIOFHFUYBLOLW-UHFFFAOYSA-N |
| SMILES | C12=C(C#N)C=NN1C=C(OCC(O)(C)C)C=C2C1=CC=C(N2CC3CC(N3CC3=CC=C(OC)N=C3)C2)N=C1 |
| FDA UNII | CEGM9YBNGD |
| NCI Drug Dictionary | selpercatinib |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
LOXO-292 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0084279 | Selpercatinib 99.87% | 2152628-33-4 | 5mg | $250 | 2021-12-16 | Buy |
| ChemScene | CS-0084279 | Selpercatinib 99.87% | 2152628-33-4 | 10mg | $350 | 2021-12-16 | Buy |
| ChemScene | CS-0084279 | Selpercatinib 99.87% | 2152628-33-4 | 50mg | $1100 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573122 | LOXO-292(Selpercatinib) >98% | 2152628-33-4 | 100mg | $1283.5 | 2021-12-16 | Buy |
| ChemScene | CS-0084279 | Selpercatinib 99.87% | 2152628-33-4 | 100mg | $1800 | 2021-12-16 | Buy |
LOXO-292 Chemical Properties,Uses,Production
Uses
Selpercatinib is a highly selective, potent RET inhibitor, an oral drug used to treat cancers in people whose tumours have been altered (mutated or fused) in specific genes (RET stands for "rearrangement during transfection").
Side effects
Selpercatinib can cause serious side effects including liver toxicity, high blood pressure, heart rhythm changes due to prolongation of heart electrical activity (QT prolongation), bleeding, allergic reactions, impaired wound healing and harm to an unborn baby.
Selpercatinib may cause harm to a developing fetus or a newborn baby.
storage
Store at -20°C
Dosage
The recommended selpercatinib dose based on body weight is:
(1) Less than 50 kg: 120 mg orally twice daily
(2) 50 kg or greater: 160 mg orally twice daily
LOXO-292 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 179)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 241 | 58 |
| Zison Pharmaceutical (Shandong) Co., Ltd. | +86-0086-531-88259693 +86-18660188356 | maguanglei@zisonpharm.com | China | 53 | 58 |
| Jinan Million Pharmaceutical Co., Ltd | +86-531-68659554 +8613031714605 | info@millionpharm.com | China | 153 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 525 | 58 |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 951 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Qiuxian Baitai New Material Co., LTD | +8618330912755 | sale2@hbyalin.com | China | 1677 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
Related articles
- LOXO-292: A Promising RET Inhibitor with Strong Anti-Tumor Effects and Manageable Adverse Events
- LOXO-292 inhibits RET-pathway, demonstrating anti-tumor effects and dose-proportional pharmacokinetics. Common adverse events ....
- Mar 4，2024
- Selpercatinib: Synthesis and Description
- Selpercatinib (LOXO-292) is synthesised using sulfonyl chloride as a raw material by chemical reaction.
- Jan 5，2024
- LOXO-292: Bioactivity and Chemicaland toxicological studies
- LOXO-292 is a selective and potent RET inhibitor,it is a novel broad-spectrum anticancer?drug with the targeted?function for R....
- Dec 20，2022
View Lastest Price from LOXO-292 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | Selpercatinib(LOXO-292)
2152628-33-4
|
US $2.00 / kg | 1kg | 99% | 30KG/M | Jinan Million Pharmaceutical Co., Ltd | |
 |
2024-04-22 | Selpercatinib
2152628-33-4
|
US $80.00-60.00 / kg | 1kg | 99% | 1000 | hebei hongtan Biotechnology Co., Ltd | |
 |
2024-04-22 | LOXO-292
2152628-33-4
|
US $50.00-30.00 / KG | 1KG | 99% | 500 | hebei hongtan Biotechnology Co., Ltd |
-
- Selpercatinib(LOXO-292)
2152628-33-4
- US $2.00 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
-
- Selpercatinib
2152628-33-4
- US $80.00-60.00 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
-
- LOXO-292
2152628-33-4
- US $50.00-30.00 / KG
- 99%
- hebei hongtan Biotechnology Co., Ltd
CPD2206
LOXO-292; LOXO292;LOXO 292
LOXO-292,Selpercatinib
Selpercatinib(LOXO-292)
6-?(2-?Hydroxy-?2-?methylpropoxy)?-?4-?[6-?[6-?[(6-?methoxy-?3-?pyridinyl)?methyl]?-?3,?6-?diazabicyclo[3.1.1]?hept-?3-?yl]?-?3-?pyridinyl]?pyrazolo[1,?5-?a]?pyridine-?3-?carbonitrile
Pyrazolo[1,5-a]pyridine-3-carbonitrile, 6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]-
LOXO-292 USP/EP/BP
6-(2-hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxypyridin-3-yl)methyl]-3,6-diazabicyclo[3.1.1]heptan-3-yl]pyridin-3-yl]pyrazolo[1,5-a]pyridine-3-carbonitrile
Inhibitor LOXO-292
ARRY-192)
LOX-292
Selpercatinib (LOXO-292, ARRY-192)
LOX0292
Serpatinib
SELPERCATINIB
LOXO-292
13C,2H3]-Selpercatinib
Diethyl N-[5-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)
methyll-N-methylamino]-2-thenoyll-L-glutamate
2152628-33-4
GS
API
2152628-33-4