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MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem Structure
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem structure
CAS No.
869577-53-7
Chemical Name:
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem
Synonyms
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem;Methanesulfonamide, N-[4-[4-[(2-thiiranylmethyl)sulfonyl]phenoxy]phenyl]-
CBNumber:
CB34813931
Molecular Formula:
C16H17NO5S3
Molecular Weight:
399.5
MDL Number:
MOL File:
869577-53-7.mol
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MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem Properties

Boiling point 614.6±65.0 °C(Predicted)
Density 1.474±0.06 g/cm3(Predicted)
pka 8.13±0.10(Predicted)

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth FM172647 MMP-2/MMP-9 Inhibitor V 869577-53-7 500ug $300 2021-12-16 Buy
Product number Packaging Price Buy
FM172647 500ug $300 Buy

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem Chemical Properties,Uses,Production

General Description

A cell-permeable sulfonamido analog of SB-3CT (Cat. No. 444274) that displays enhanced aqueous solubility and improved selectivity (Ki = 16 nM, 180 nM, and 900 nM for MMP-2, MMP-9, and MMP-14, respectively). Inhibits MMP-3, MMP-7, and MMP-1 only at much higher concentrations (Ki = 3.6 μM, 295 μM, and >25 μM, respectively). Binds to the enzyme active site and acts as an irreversible inhibitor. Reported to potently suppress cell migration and invasion of HT1080 cells (80% inhibition at 2 μM and >25% inhibition at 100 nM, respectively). Unlike the general MMP inhibitor GM6001 (Cat. No. 364205), this inhibitor does not block the activation of cellular pro-MMP-2 by MT1-MMP.

Biochem/physiol Actions

Cell permeable: yes

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
MMP-2/MMP-9 Inhibitor V - CAS 869577-53-7 - Calbiochem Methanesulfonamide, N-[4-[4-[(2-thiiranylmethyl)sulfonyl]phenoxy]phenyl]- 869577-53-7