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InSolution TAPI-1 - Calbiochem

InSolution TAPI-1 - Calbiochem Structure
InSolution TAPI-1 - Calbiochem structure
CAS No.
Chemical Name:
InSolution TAPI-1 - Calbiochem
Synonyms
InSolution TAPI-1 - Calbiochem
CBNumber:
CB34817388
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
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InSolution TAPI-1 - Calbiochem price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 579053 InSolution TAPI-1 - Calbiochem InSolution TAPI-1, CAS 171235-71-5, is a 10 mM solution of TAPI-1 in DMSO. A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE. 500μg $238 2023-06-20 Buy
Product number Packaging Price Buy
579053 500μg $238 Buy

InSolution TAPI-1 - Calbiochem Chemical Properties,Uses,Production

General Description

A structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α convertase; ADAM17). However, TAPI-1 is more stable in serum than TAPI-0. TAPI-1 Blocks the shedding of several cell surface proteins such as TNF-α, IL-6 receptor, and p60 and p80 TNF receptors. Inhibits constitutive (IC50 = 8.09 μM) and muscarinic receptor-stimulated (IC50 = 3.61 μM) sAPPa release in HEK-293 cells expressing muscarinic receptors. Also blocks the TACE-dependent constitutive release of co-transfected APP(695) (IC50 = 920 nM).

Biochem/physiol Actions

Target IC50: 8.09 μM, 3.61 μM in blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors

InSolution TAPI-1 - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

InSolution TAPI-1 - Calbiochem Suppliers

Global( 2)Suppliers
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Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
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InSolution TAPI-1 - Calbiochem